Protective effect of phosphatidylcholine liposomes in cats with hemorrhagic shock

Крыжановский, Г. Н.; Leskova, G. F.; Udovichenko, V. I.; Kulikova, O. S.

doi:10.1007/bf02543430

Cited by 2 publications

(1 citation statement)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Intravenous injections o f PC to patients with hepatocirrhosis normalizes lipid composition of the erythrocyte membrane [10]. PC-containing liposomes reduce the intensity o f free radical processes in the liver and stabilize the phospholipid bilayer o f hepatocyte plasma membranes [7]. The hepatoprotective properties of Phospholiv are determined not only by PC but also by high biological activity o f GA, a structural analog of steroid hormones (mineral-and glucocorticoids).…”

Section: Resultsmentioning

confidence: 99%

Hepatoprotective properties of phospholiv, a preparation containing phosphatidylcholine from sunflower seeds and glycyrrhizic acid, in modeled cirrhosis of rat liver

et al. 1997

View full text Add to dashboard Cite

Hepatoprotective effect of Phospholiv, a phospholipid preparation containing phosphatidylcholine from sunflower seeds and glycyrrhizic acid trisodium salt, is studied using a model of CC14-induced cirrhosis of the liver. Phospholiv protects hepatic tissues from necrotic and dystrophic changes and prevents the development of cirrhosis. Phospholiv restores impaired RNA and protein synthes is under conditions of chronic intoxication.

show abstract

Section: Resultsmentioning

confidence: 99%

Hepatoprotective properties of phospholiv, a preparation containing phosphatidylcholine from sunflower seeds and glycyrrhizic acid, in modeled cirrhosis of rat liver

et al. 1997

View full text Add to dashboard Cite

show abstract

Phospholipids in mitochondrial dysfunction during hemorrhagic shock

Leskova

2016

J Bioenerg Biomembr

View full text Add to dashboard Cite

Energy deficiency plays a key role in the development of irreversible shock conditions. Therefore, identifying mitochondrial functional disturbances during hemorrhagic shock should be considered a prospective direction for studying its pathogenesis. Phospholipid (PL)-dependent mechanisms of mitochondrial dysfunction in the brain (i.e., in the frontal lobes of the cerebral hemispheres and medulla oblongata) and liver, which, when damaged, leads to an encephalopathy, are examined in this review. These mechanisms show strong regional specificity. Analyzing the data presented in this review suggests that the basis for mitochondrial functional disturbances is cholinergic hyperactivation, accompanied by a choline deficiency and membrane phosphatidylcholine (PC) depletion. Stabilization of the PL composition in mitochondrial membranes using "empty" PC liposomes could be one of the most important methods for eliminating energy deficiency during massive blood loss.

show abstract

Protective effect of phosphatidylcholine liposomes in cats with hemorrhagic shock

Cited by 2 publications

References 6 publications

Hepatoprotective properties of phospholiv, a preparation containing phosphatidylcholine from sunflower seeds and glycyrrhizic acid, in modeled cirrhosis of rat liver

Hepatoprotective properties of phospholiv, a preparation containing phosphatidylcholine from sunflower seeds and glycyrrhizic acid, in modeled cirrhosis of rat liver

Phospholipids in mitochondrial dysfunction during hemorrhagic shock

Contact Info

Product

Resources

About