Hepatoprotective properties of phospholiv, a preparation containing phosphatidylcholine from sunflower seeds and glycyrrhizic acid, in modeled cirrhosis of rat liver

Podobed, O. V.; Fedorova, L. M.; Abakumova, O. Yu.; Yakusheva, I. V.; Tsvetkova, T. A.; Gavril'chak, A. V.; Шехтер, А. Б.; Karyakin, A. V.

doi:10.1007/bf02446996

“…Moreover, because of its ability to scavenge free radicals,[12] it protects the liver cells against necrotic and dystrophic changes caused by TMX and thus prevents the development of hepatocirrhosis. The results obtained in this study are in good agreement with the previous findings [33,34]…”

Section: Discussionsupporting

confidence: 93%

Modulation of tamoxifen-induced hepatotoxicity by tamoxifen–phospholipid complex

Jena

¹

,

Suresh

²

,

Sangamwar

³

2015

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

show abstract

“…Upon oral administration of SST, glycyrrhizic acid (GA), an aglycon of GL, but not GL itself, has been detected in the plasma of the rats [87,88], and a few detailed studies on the pharmacokinetics of GL and its metabolites upon oral administration of SST, have been performed. GL and GA have a wide variety of pharmacological effects, including hepatoprotective [89,90], immunomodulatory [91][92][93], anti-inflammatory [94,95], anti-mutagenic [96,97] and antiulcer effects [98]. Inhibitory effect of GL on HIV- [99] and SARS-associated coronavirus [100] has been also reported.…”

Section: Pharmacological Activity Of Triterpene Saponinsmentioning

confidence: 98%

Separation and isolation methods for analysis of the active principles of Sho-saiko-to (SST) oriental medicine

Ohtake

¹

,

Nakai

²

,

Yamamoto

³

et al. 2004

Journal of Chromatography B

View full text Add to dashboard Cite

Sho-saiko-to (SST) was introduced into Japan as an oriental classical medicine from China approximately 1500 years ago, and it is currently the most representative Kampo medicine (traditional Japanese medicine). SST is manufactured in Japan as an ethical drug on a modern industrial scale in which the quality of ingredients is standardized with Good Manufacturing Practices (GMP) regulation. SST is widely used for the treatment of chronic hepatitis. Experimental and clinical studies including multi-center, placebo-controlled, double-blind studies have demonstrated the various pharmacological effects of SST. SST is prepared from the hot water extraction of seven raw materials, therefore many kinds of constituents are included. Three-dimensional (3D) HPLC analysis is useful for obtaining many kinds of constituents, especially low molecular ultraviolet (UV) quenching compounds, contained in SST as well as its fractions. Fingerprint pattern provided by 3D HPLC analysis makes possible to identify the overall-viewing of SST. Databases of UV spectra of the components of medicinal herbs obtained by reversed-phase (RP) HPLC using a photodiode array (PDA) and fingerprint patterns of crude drugs made by 3D HPLC analysis facilitate the identification, analysis and quality of herbal drugs. Studies using both PDA HPLC and an amino acid analysis with a fluorometric detector have found that SST contains fifteen major low molecular compounds (i.e. baicalin, wogonin-7-O-glucuronide, liquiritin, their three aglycons, liquiritin apioside, glycyrrhizin, saikosaponin b1, saikosaponin b2, ginsenoside Rg1, ginsenoside Rb1, (6)-gingerol, (6)-shogaol and arginine). These compounds have various pharmacological actions, and are assumed to be responsible, at least partly, for the pharmacological effects of SST. Although there have only been a few investigations on high molecular compounds with pharmacological actions contained in SST, several kinds of polysaccharides have been isolated from constituent herbs of SST. This review paper summarizes analytical methods of separation, isolation and identification of compounds with biological activities from SST, which is a mixture drug of medicinal herbs. Accordingly, this paper would not focus on methods of separation, isolation and analysis of particular compounds from each constituent herb of SST.

show abstract

“…Upon oral administration of SST, glycyrrhizic acid (GA), an aglycon of GL, but not GL itself, has been detected in the plasma of the rats [87,88], and a few detailed studies on the pharmacokinetics of GL and its metabolites upon oral administration of SST, have been performed. GL and GA have a wide variety of pharmacological effects, including hepatoprotective [89,90], immunomodulatory [91][92][93], anti-inflammatory [94,95], anti-mutagenic [96,97] and antiulcer effects [98]. Inhibitory effect of GL on HIV- [99] and SARS-associated coronavirus [100] has been also reported.…”

Section: Pharmacological Activity Of Triterpene Saponinsmentioning

confidence: 99%

Separation and isolation methods for analysis of the active principles of Sho-saiko-to (SST) oriental medicine

OHTAKE¹,

NAKAI²,

YAMAMOTO³

et al. 2004

Journal of Chromatography B

View full text Add to dashboard Cite

Sho-saiko-to (SST) was introduced into Japan as an oriental classical medicine from China approximately 1500 years ago, and it is currently the most representative Kampo medicine (traditional Japanese medicine). SST is manufactured in Japan as an ethical drug on a modern industrial scale in which the quality of ingredients is standardized with Good Manufacturing Practices (GMP) regulation. SST is widely used for the treatment of chronic hepatitis. Experimental and clinical studies including multi-center, placebo-controlled, double-blind studies have demonstrated the various pharmacological effects of SST. SST is prepared from the hot water extraction of seven raw materials, therefore many kinds of constituents are included. Three-dimensional (3D) HPLC analysis is useful for obtaining many kinds of constituents, especially low molecular ultraviolet (UV) quenching compounds, contained in SST as well as its fractions. Fingerprint pattern provided by 3D HPLC analysis makes possible to identify the overall-viewing of SST. Databases of UV spectra of the components of medicinal herbs obtained by reversed-phase (RP) HPLC using a photodiode array (PDA) and fingerprint patterns of crude drugs made by 3D HPLC analysis facilitate the identification, analysis and quality of herbal drugs. Studies using both PDA HPLC and an amino acid analysis with a fluorometric detector have found that SST contains fifteen major low molecular compounds (i.e. baicalin, wogonin-7-O-glucuronide, liquiritin, their three aglycons, liquiritin apioside, glycyrrhizin, saikosaponin b1, saikosaponin b2, ginsenoside Rg1, ginsenoside Rb1, (6)-gingerol, (6)-shogaol and arginine). These compounds have various pharmacological actions, and are assumed to be responsible, at least partly, for the pharmacological effects of SST. Although there have only been a few investigations on high molecular compounds with pharmacological actions contained in SST, several kinds of polysaccharides have been isolated from constituent herbs of SST. This review paper summarizes analytical methods of separation, isolation and identification of compounds with biological activities from SST, which is a mixture drug of medicinal herbs. Accordingly, this paper would not focus on methods of separation, isolation and analysis of particular compounds from each constituent herb of SST.

show abstract

Hepatoprotective properties of phospholiv, a preparation containing phosphatidylcholine from sunflower seeds and glycyrrhizic acid, in modeled cirrhosis of rat liver

Cited by 3 publications

References 5 publications

Modulation of tamoxifen-induced hepatotoxicity by tamoxifen–phospholipid complex

Modulation of tamoxifen-induced hepatotoxicity by tamoxifen–phospholipid complex

Separation and isolation methods for analysis of the active principles of Sho-saiko-to (SST) oriental medicine

Separation and isolation methods for analysis of the active principles of Sho-saiko-to (SST) oriental medicine

Contact Info

Product

Resources

About