Protective effect of Panax ginseng against serum biochemical changes and apoptosis in liver of rats treated with carbon tetrachloride (CCl4)

Karakuş, Emre; Karadeniz, Ali; Şimşek, Nejdet; Can, İsmail Özgür; Kara, Adem; Yıldırım, Serap; Kalkan, Yıldıray; Kisa, Fikrullah

doi:10.1016/j.jhazmat.2011.08.027

Cited by 91 publications

(71 citation statements)

References 53 publications

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“…On the other hand, the pretreatment with PG significantly reduced the values of both enzymes as compared to the APAP-only treated group. These results are in agreement with the previous studies performed using PG and some hepatotoxic agents such as aflatoxin, carbon tetrachloride, and cadmium (Abdel-Wahhab et al, 2010;Cayir et al, 2011;Karakus et al, 2011). Hepatoprotective plants contain a variety of chemical components such as alkaloids, xanthenes, phenols, flavonoids, glycosides saponins, and terpenes (Bhawna, 2009).…”

Section: +supporting

confidence: 91%

“…Previous studies have demonstrated that ginseng has antioxidant activity as it contains ginsenosides, phenolic acids, flavonoids, and saponins. These properties of the ginseng are thought to provide many beneficial preventative effects against organ damage (He et al, 2012;Karakus et al, 2011;Ramesh et al, 2012). These findings could be interpreted as indicating that PG may possess the capacity to protect the structural integrity of hepatocytes and mitochondria from the damage induced by APAP.…”

Section: +mentioning

confidence: 99%

“…This effect might be due to the potential antioxidant and free radical scavenging activities of PG. Also, these antioxidant and radical scavenge activities, and other effects such as antidiabetogenic, antiapoptotic, and immunomodulator activities of PG in pancreas, heart, liver, kidney, and blood tissues, have been demonstrated (Amin et al, 2011;Chen et al, 2011;Karakus et al, 2011;Liu et al, 2010).…”

Section: +mentioning

confidence: 99%

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Protective effect of Panax ginseng against N-acetyl-p-aminophenol-induced hepatotoxicity in rats

Uzkeser¹

2012

Afr. J. Pharm. Pharmacol.

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Panax ginseng (PG) has been commonly used as medicinal herb for the treatment of various diseases in Eastern Asia for thousands of years. This study was designed to investigate the protective effect of PG against paracetamol-(N-acetyl-p-aminophenol; APAP)-induced liver damage in rats. Thirty-two albino Wistar rats were divided into four groups: Group C (control); Group APAP (gavaged orally with APAP (APAP, 2 g/kg, single dose); Group PG 100 mg/kg + APAP or 200 mg/kg + APAP (these two groups were treated by gavaging with PG (100 or 200 mg/kg) for 30 days following a single dose of APAP). APAP treatment alone induced hepatotoxicity, evidenced by significant increases in malondialdehyde (MDA) level and serum activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and tumor necrosis factor-α (TNF-α). In addition, the level of GSH in the liver was significantly reduced, as were the activities of superoxide dismutase (SOD) and catalase (CAT). Liver histopathological examination showed that APAP administration induced centrilobular necrosis and infiltration of lymphocytes. However, these biochemical and histological changes were prevented by PG pretreatment. In conclusion, our results suggest that PG may be considered a protective medicinal herb against APAP-induced liver injury.

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Section: +supporting

confidence: 91%

Section: +mentioning

confidence: 99%

Section: +mentioning

confidence: 99%

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Protective effect of Panax ginseng against N-acetyl-p-aminophenol-induced hepatotoxicity in rats

Uzkeser¹

2012

Afr. J. Pharm. Pharmacol.

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“…32,33 Furthermore, Ndidi et al 34 reported the proximate, antinutrients and mineral composition of raw and processed African yam bean. Studies have shown that CCl 4 infusion or inhalation elicits chemical-induced multiple organ lesions such as fibrosis, cirrhosis and hepatocarcinoma, 12,13,35,36 and by extension, renal dysfunction in animal models. 5,6,12 Organ lesion and ensuing pathology elicit wide variations in concentrations of metabolites and elevation of non-functional plasma enzymes in blood samples of experimental animals.…”

Section: Introductionmentioning

confidence: 99%

Functional Assessments and Histopathology of Hepatorenal Tissues of Wistar Rats Infused with Carbon Tetrachloride and Treated with Raw and Hydrothermal Processed Herbs

Ojiako¹,

Chikezie²,

Ukairo³

et al. 2017

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Background and Aim: Herbal remedies offer another strategy for alleviation of co-existing liver and kidney pathologic conditions. Objective: The present study ascertained the functional integrity of hepatic and renal tissues, concurrently with blood lipid patterns, of Wistar rats infused with CCl 4 and treated with raw and hydrothermal processed herbs, namely, Monodora myristica, Chromolaena odorata, Buccholzia coriacea and Sphenostylis stenocarpa. Materials and Methods: Measurement of phytochemical contents of the herbs was according to standard methods. The rats were randomly designated on the basis of diets and treatments received for 28 consecutive days. Fibrosis was induced in the Wistar rats by single dose intra-peritoneal injection of CCl 4 for 2 consecutive days. Liver and kidney function tests and serum lipid profile were measured using spectrophotometric methods. Renal and hepatic tissues were subjected to histopathological examinations. Results: The concentrations of alkaloids in the four herbal extracts were within the range of 4.83 ± 0.03 -31.33 ± 0.29 mg/100 g sample, whereas the concentrations of saponins varied within a relatively narrow range: 0.33 ± 0.09 -4.33 ± 0.02 mg/100 g dry sample; p > 0.05. The activity ratios of AST to ALT of the rat groups were generally less than 1.0 unit. Atherogenic indices of fibrotic rats were within the following ranges: TAG/HDL-C ratio (3.59 ± 0.03 -6.76 ± 0.06), TC/HDL-C ratio (3.72 ± 0.02 -6.94 ± 0.05) and LDL-C/HDL-C ratio (2.00 ± 0.01 -4.59 ± 0.02). Conclusion: Losses in phytochemical contents following hydrothermal processing of the herbs did not substantially affect their overall therapeutic scores against morphological and functional impairments of hepatic and renal tissues following CCl 4 intoxication of the rats.

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“…cancer, rheumatoid arthritis, ischemic diseases, neurological disorders and diabetes). Also, the pancreatic β-cells are very sensitive to injury caused by the free radicals [5][6][7][8] . The most striking example of β-cell damage is the severe injury induced by alloxan or STZ.…”

Section: Introductionmentioning

confidence: 99%

Melatonin Ratlarda Alloxan İle İndüklenen Diyabet Sonrası Oluşan Testiküler Hasarı ve Oksidatif Etkileri Hafifletir

Akman¹,

Şengül²,

Özkanlar³

et al. 2015

Kafkas Univ Vet Fak Derg

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The aim of this study was to examine the protective effect of melatonin (MLT) on the alloxan-induced post-diabetic testicular damage in rats. Forty-eight Sprague Dawley male rats were divided into four groups (n=12). Group C received 0.9% saline for 45 days, as control. Group DM (Diabetes Mellitus) was injected by 120 mg/kg single dose alloxan intraperitoneally (IP). Group MLT was treated by 10 mg/ kg/d MLT IP for 45 d. Group DM+MLT was treated by 10 mg/kg/d MLT IP for 45 days following alloxan injection. Six animals on days 15 and the remaining 6 on days 45 were sacrificed in each group after the initiation of the study. Testis tissues and blood samples were collected to investigate blood glucose, oxidant and antioxidant statues, sperm parameters, and histopathological and 8-hydroxy-2′-deoxyguanosine (8-OHdG)-immunopositive cell examinations. MLT treatment of diabetic rats prevented the increases in malondialdehyde (MDA) levels and 8-OHdG concentrations, and the decreases in the GSH and SOD levels observed in DM groups. Alloxan administration depressed the sperm concentration, the number of progressively motile spermatozoa, premature acrosome reaction (AR) and calcium ionophore A23187-induced AR rates, without any change in dead and/or abnormal sperm rates in DM group. Histopathological and immunohistochemical observations also revealed that MLT-treated diabetic rats had an enhanced histological architecture and DNA damage in testis. These findings suggest that MLT treatment prevents the testicular damage by declining the oxidative stress, but it did not recover the depressed sperm parameters in diabetic rats. Keywords: Diabetes, Melatonin, Rat, Testis Melatonin Ratlarda Alloxan İle İndüklenen Diyabet Sonrası Oluşan Testiküler Hasarı ve Oksidatif Etkileri Hafifletir ÖzetBu çalışmanın amacı, ratlarda alloxan ile oluşturulan diyabet sonrası gözlenen testiküler hasar üzerine melatonin'in (MLT) koruyucu etkisini incelemekti. Araştırmada kullanılan 48 adet Sprague Dawley ırkı erkek rat 4 gruba ayrıldı (n=12). Kontrol grubu olan Grup C'ye 45 gün süreyle %0.9 serum fizyolojik verildi. Grup DM'ye (Diabetes Mellitus) tek doz alloxan (120 mg/kg) intraperitoneal (IP) olarak enjekte edildi. Grup MLT'ye 45 gün süreyle 10 mg/kg/gün dozda MLT IP olarak enjekte edildi. Grup DM+MLT'ye alloxan enjeksiyonunu takiben 45 gün süreyle 10 mg/kg/gün dozda MLT IP olarak uygulandı. Her gruptan 6 hayvana araştırma başladıktan 15 gün sonra, diğer 6 hayvana ise 45 gün sonra ötenazi uygulandı. Kan glikoz seviyesi, oksidan ve antioksidan durumları, sperm parametreleri ve histopatolojik ile 8-hydroxy-2′-deoxyguanosine (8-OHdG)-immunopozitif hücre incelemeleri için testis dokusu ve kan örnekleri alındı. Diyabetik ratlara yapılan MLT uygulamasının, grup DM'de görülen malondialdehyde (MDA) seviyesi ile 8-OHdG yoğunluğundaki artışı ve glutathion (GSH) ile superoxide dismutase (SOD) seviyelerindeki azalmayı önlediği belirlendi. Alloxan uygulaması grup DM'de sperm yoğunluğu, motil sperm sayısı, prematüre akrozom reaksiyonu (AR) ve calcium io...

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Protective effect of Panax ginseng against serum biochemical changes and apoptosis in liver of rats treated with carbon tetrachloride (CCl4)

Cited by 91 publications

References 53 publications

Protective effect of Panax ginseng against N-acetyl-p-aminophenol-induced hepatotoxicity in rats

Protective effect of Panax ginseng against N-acetyl-p-aminophenol-induced hepatotoxicity in rats

Functional Assessments and Histopathology of Hepatorenal Tissues of Wistar Rats Infused with Carbon Tetrachloride and Treated with Raw and Hydrothermal Processed Herbs

Melatonin Ratlarda Alloxan İle İndüklenen Diyabet Sonrası Oluşan Testiküler Hasarı ve Oksidatif Etkileri Hafifletir

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