Protective effect of oxytocin through its anti-inflammatory and antioxidant role in a model of sepsis-induced acute lung injury: Demonstrated by CT and histological findings

Pulmonary Fibrosis as a Result of Acute Lung Inflammation: Molecular Mechanisms, Relevant In Vivo Models, Prognostic and Therapeutic Approaches

“…The most significant contributor to ARDS morbidity and mortality in recent years was the COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), so named because of its high homology with SARS-CoV-1, the virus responsible for the outbreak of severe acute respiratory syndrome in 2002–2003 [ 36 , 37 , 38 ]. However, a great number of stimuli and diseases may serve as etiological factors of ALI and ARDS, including bacterial (Streptococcus pneumonia or Staphylococcus aureus [ 39 , 40 ]) and viral (influenza A virus or rhinovirus [ 41 , 42 ]) pneumonia, continuous mechanical ventilation [ 43 , 44 , 45 ], chemicals (chlorine, phosgene and industrial aerosols [ 46 , 47 , 48 ]), electronic cigarettes, and vape [ 49 , 50 ], acute brain injury [ 51 , 52 ], sepsis [ 53 , 54 ], acute pancreatitis [ 55 ] and many other pathologies.…”

Atosiban-induced acute pulmonary edema: A rare but severe complication of tocolysis

“…Maternal physiologic cardiopulmonary adaptations during pregnancy such as an increased maternal blood volume, cardiac output and oxygen consumption, predispose a pregnant women to developing APE [ 2 ]. On the other hand, it is reported that oxytocin has a protective effect in acute lung injury, cardiac ischemia, and cardiomyopathies acting through oxytocin receptors (OXTRs) and vasopressin V1A receptors (V1ARs) [ [38] , [39] , [40] ]. As an oxytocin–vasopressin receptor antagonist that competitively inhibits oxytocin from binding to its receptors, atosiban has been reported to abolish the cardiopulmonary protective effect of oxytocin in in vitro and in vivo studies [ [41] , [42] , [43] ].…”

Sepsis-Induced Acute Lung Injury Is Alleviated by Small Molecules from Dietary Plants via Pyroptosis Modulation

“…As mentioned in previous sections, due to limitations of current agents like adverse reaction superposition, inevitable drug resistance and relatively heavier financial burden, naturally extracted small-molecule compounds have a broad market even though the chemically modified agents have straightforward efficacy. Until recently, the announced synthetic chemical drugs with the effect of alleviating sepsis-induced ARDS include angiopoietin-1, oxytocin, recombinant antithrombin, melatonin, pro-opiomelanocortin, recombinant thrombomodulin, unfractionated heparin, Ghrelin, LASSBio596 combined with surfactant, MCC950, ilprost, etc. More details on their principal mechanisms are presented in Table .…”