Protective effect of olive and juniper leaves extracts on nephrotoxicity induced by thioacetamide in male mice

Al-Attar, Atef M.; Al-Robai, Ali A.; Almalki, Daklallah A.

doi:10.1016/j.sjbs.2015.08.013

Cited by 59 publications

(43 citation statements)

References 34 publications

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“…The olive tree (Olea europaea), family: Oleaceae, and in particular, its leaves have been used for the treatment of wounds, fever, diabetes, gout, atherosclerosis, and hypertension since ancient times [163]. In the Mediterranean area, olive leaves are one of the by-products of farming of the olive grove; they can be found in high amounts in the olive oil industries and they accumulate during pruning of the olive trees [164].…”

Section: Olive Tree (Olea Europaea)mentioning

confidence: 99%

Prevention of Nephropathy by Some Natural Sources of Antioxidants

Azab¹,

Albasha²,

Elsayed³

2017

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Nephrotoxicity is one of the most common kidney problems and occurs when the body is exposed to a drug or toxin. Natural sources of antioxidants may serve as a vital source of potentially useful new compounds for the development of an effective therapy to combat a variety of kidney problems. Natural antioxidants have a variety of biochemical actions such as inhibition of reactive oxygen species production, scavenging of free radicals. The present review aims to summarize the recent articles which studied some of the nephrotoxic agents, and alleviation of nephrotoxicity using of some natural products possessing antioxidant properties. Our review shows the oxidative damage and renal disorders induced in human and experimental animals by nephrotoxic agents such as gentamicin, alcohol, nicotine, adenine, glycerol, ethylene glycol, sodium nitrite, mercuric chloride, AlCl 3 , lead acetate, carbon tetrachloride (CCl 4 ), furosemide, carbendazim, diazinon, heat stress, and γ-radiation. Also, nephrotic disorders caused in diabetic rats, patients, cirrhotic ascetic patients, and ischemia-reperfusion. Administration of natural sources of antioxidants such as curcumin, garlic, fenugreek, parsley, peppermint, pomegranate, propolis, olive leaves, rosemary, and sesame attenuated both physiological and histopathological alterations induced in the kidney by the nephrotoxic agent and certain diseases. The nephroprotective effect of the former natural sources of antioxidants may be due to the enhancement of antioxidant activity and inhibition of tissue lipid peroxidation. It can be concluded that administration of curcumin, garlic, fenugreek, parsley, peppermint, pomegranate, propolis, olive leaves, rosemary, and sesame showed a remarkable kidney protection against nephrotoxic agents, and diseases induced renal dysfunctions in human and experimental animals. So, the present study recommended that the consumption of these natural sources of antioxidants may be useful for human exposure to nephrotoxic agents and patients who suffer from renal diseases.

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Section: Olive Tree (Olea Europaea)mentioning

confidence: 99%

Prevention of Nephropathy by Some Natural Sources of Antioxidants

Azab¹,

Albasha²,

Elsayed³

2017

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“…The kidney is known to be hugely susceptible to damage caused by various toxic elements as large volume of blood flows through it and the toxins filtered usually gets concentrated in the kidney tubules [36]. High protein content in urea known as Proteinuria is a urine marker which is a common indicator for various kidney pathologies and dysfunction [37].…”

Section: Discussionmentioning

confidence: 99%

Acute and sub-acute (30-day) toxicity studies of Aegialitis rotundifolia Roxb., leaves extract in Wistar rats: safety assessment of a rare mangrove traditionally utilized as pain antidote

2019

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Acute and sub-acute (30-day) toxicity studies of Aegialitis rotundifolia Roxb., leaves extract in Wistar rats: safety assessment of a rare mangrove traditionally utilized as pain antidote Abstract Background: Aegialitis rotundifolia Roxb., (Plumbaginaceae) is a small mangrove tree or shrub traditionally used by the local healers of mangroves for curing pain and inflammation. However, there are no scientific reports of its toxicological properties which would guarantee the safety of its folkloric usage as a potent pain reliever. Therefore, the present study deals in acute and sub-acute (30-day) toxicity studies of Aegialitis rotundifolia ethanolic leaves extract (ARELE) on male and female Wistar rats administered through oral gavage.Methods: Acute toxicity study was conducted at a single oral dose of 1000, 1500, and 2000 mg/kg, body weight (b.wt.) for 14 days with a special emphasis on the first four hours after drug administration to find out any mortality and morbidity. In sub-acute toxicity, the extract at the doses of 125, 250 and 500 mg/kg, b.wt., was administered orally for 30 days. Important parameters such as general behaviour, body and organ weight, urinalysis, haematological and biochemical profile, organ macroscopy and microscopy were conducted. Organ sample of liver, kidney, pancreas, heart, lungs, and stomach were taken from both male and female rats, whereas the sample of testis and ovary was taken from male and female rats respectively for organ necropsy and histopathological studies. Neurobehavioral toxicity was conducted by performing a functional observational battery (FOB) and locomotor activity on the initial and final week of the 30-day study period. Results:No mortality or any major signs of morbidity was recorded for acute toxicity except for the limit dose (2000 mg/kg, b.wt.) which produced a slight short-term sedative effect. In sub-acute toxicity, no major alteration was observed in the evaluated parameters. However, few minor changes were recorded for high dose (500 mg/kg, b.wt.) group. Conclusion:The results of the present study showed that oral administration of Aegialitis rotundifolia ethanolic leaves extract did not produce any severe toxic effects in both acute and sub-acute studies in Wistar rats. Therefore, usage of an appropriate amount of Aegialitis rotundifolia leaves extract preferably at low doses for its traditional use should be considered safe.

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“…It was observed that single dose administration of TAA to the experimental animals significantly increased serum uric acid (mg/dL), urea (mg/dL), creatinine (mg/dL), while there was no significant alteration serum level of calcium (mg/dL), magnesium (mg/dL), and phosphorus (mg/dL) level as compare to the rats of normal control animals (Figures 4 and 5). These changes are clear indication of an acute nephrotoxicity [8,41,42].…”

Section: Impression Of Novel Treatment On Uric Acid Urea Creatininementioning

confidence: 97%

“…Additionally, TAA also causes damage to the kidney, brain, stomach, intestine, spleen and lungs. Increased level of serum uric acid, urea and creatinine are marker of the impairment in kidney functions and kidney toxicities [8].…”

Section: Biomedical Research 2018; 29 (15): 3106-3116mentioning

confidence: 99%

Comparative biochemical and histopathological studies on the efficacy of metformin and Nigella sativa oil against thioacetamide-induced acute hepatorenal damage in rats

Ahmad¹,

Alkreathy²

2018

biomedicalresearch

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Background: Metformin is the first-line oral anti-diabetic drug and Nigella sativa (NS) have been used as traditional medicine to cure/prevent a wide range of diseases in different part of the world, particularly in Saudi Arabia. Objective: To carry out the comparative biochemical and histopathological studies on the efficacy of metformin, Nigella sativa oil (NSO) against thioacetamide (TAA)-induced acute hepatorenal damage in rats. Materials and methods: Forty-eight male Albino Wistar rats were randomly divided in to eight groups with six rats in each group. Group-I (normal control): received normal saline (1 ml/kg, p.o.), group II (toxic control): received normal saline (1 ml/kg, p.o.) and TAA (500 mg/kg, i.p.), group-III (NSO per se): NSO (2 ml/kg, p.o.), group IV (metformin per se): metformin (250 mg/kg/d, p.o.), group V (NSO+TAA): NSO (2 ml/kg/d p.o.)+TAA (500 mg/kg, i.p.): group VI (metformin+TAA): metformin (250 mg/kg/d, p.o.) +TAA (500 mg/kg, i.p.). Group VII (NSO+metformin +TAA): NSO (2 ml/kg, p.o.), and metformin (250 mg/kg/d, p.o.)+TAA (500 mg/kg, i.p.), group VIII (TAA+Jigreen): jigreen (1 ml/kg/d, p.o.)+TAA (500 mg/kg, i.p.). Normal saline, NSO, metformin and jigreen were administered to respective groups by gastric intubation for 7 consecutive days. On the 7 th d, 1 h after the drugs treatment, a single intraperitoneal injection of TAA (500 mg/kg,) was administered to the rats of all groups except groups I, III and IV to induce acute liver and kidney injury. All animals were sacrificed under ether anesthesia after 24 h of TAA administration. The liver and kidney function tests in the serum were evaluated to assess the toxic effects of TAA as well as the protective effects of the given treatments against TAA induced the hepatorenal toxicity. Histopathology of liver and kidney tissues was also carried out to validate the findings of biochemical investigation. Results: The results indicated that the TAA intoxicated rats showed significant increase in the alanine transaminase (ALT), aspartate transaminase (AST), gamma-glutamyl transpeptidase (GGT), alkaline phosphatase (ALP), lipid profile, uric acid, urea, creatinine, while no significant changes were observed in serum levels of calcium, magnesium and phosphorus as compared with normal control rats. In the treatment groups, combination drug therapy showed remarkable alleviation of hepatorenal toxicity in metformin plus NSO group and was congruent to that of the standard polyherbal preparation "jigreen". The histopathological studies also support the hepatorenal protective effects of metformin and NSO. Conclusion: The results of the study demonstrated that metformin+NSO protects liver and kidney against acute TAA toxicity. Overall, this study proved the ameliorative effects of metformin, NSO and metformin plus NSO combination against TAA induced hepatorenal toxicity in rats.

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Protective effect of olive and juniper leaves extracts on nephrotoxicity induced by thioacetamide in male mice

Cited by 59 publications

References 34 publications

Prevention of Nephropathy by Some Natural Sources of Antioxidants

Prevention of Nephropathy by Some Natural Sources of Antioxidants

Acute and sub-acute (30-day) toxicity studies of Aegialitis rotundifolia Roxb., leaves extract in Wistar rats: safety assessment of a rare mangrove traditionally utilized as pain antidote

Comparative biochemical and histopathological studies on the efficacy of metformin and Nigella sativa oil against thioacetamide-induced acute hepatorenal damage in rats

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