Protective effect of Nigella sativa oil against tramadol-induced tolerance and dependence in mice: Role of nitric oxide and oxidative stress

A review on therapeutic potential of Nigella sativa: A miracle herb

“…administration of the NO precursor, L-arginine (300 mg/kg). These results provide evidence that N. sativa oil appears to have a therapeutic potential in tramadol tolerance and dependence through blockade of NO overproduction and oxidative stress induced by the drug [7] . Neuroprotective effects of Aqueous and hydroalcoholic extracts of N. sativa (400 mg/ kg, orally) were evaluated for their neuroprotective effects on middle cerebral artery occluded (MCAO) rats.…”

“…A study was designed to determine whether treatment with TQ prevents and ameliorates colonic inflammation in a mouse model of inflammatory bowel disease. C57BL/6 murine colitis was induced by the administration of dextran sodium sulfate (DSS) (3% W/V) in the drinking water supplied to the mice for 7 consecutive d. The mice with colitis were treated with 5, 10, or 25 mg/kg TQ orally, and changes in body weight and macroscopic and microscopic colitis scores were examined. In addition, biochemical analyses were conducted.…”

Prospects of N-Acetylcysteine and Melatonin as Treatments for Tramadol-Induced Renal Toxicity in Albino Rats

“…7,8 Renal toxicity characterized by glomerular hemorrhage, atrophied glomeruli with collapsed tufts, wide Bowman's space, and degenerated tubules were observed in the kidneys of TD-treated rats. 9 Studies have reported lipid peroxidation, mitochondria damage, inhibition of protein synthesis and decrease in antioxidants in the kidneys of TD-treated rats [10][11][12] Melatonin (MT), a hormone produced by the pineal gland, is a potent scavenger of reactive oxidative radicals. 13 Thus, MT can prevent free radicalinduced cellular oxidative damage and can contribute to the physiological functions of the antioxidant defensive system.…”

Effect of Nigella sativa supplementation on human lipids: systematic review

“…The seeds of NS are widely used in the treatment of numerous diseases like bronchitis, asthma, diarrhea, rheumatism and skin disorders. It is also has been reported that used as liver tonic, digestive, antidiarrheal, appetite stimulant, emmenagogue, to increase milk production in nursing mothers to fight parasitic infections, and to support immune system (Goreja, 2003;Khaled, 2009;Assayed, 2010;Boskabady et al, 2010;Abdel-Zaher et al, 2011;AbdelSalam, 2012). Most of the therapeutic properties of this plant are due to the presence of thymoquinone (TQ) which is a major active chemical component of the essential oil.…”