Protective effect of monoclonal antibodies to adhesion molecules on rat liver ischemia-reperfusion injury

Attenuation of Leukocyte Adhesion by Recombinant TNF-Binding Protein After Hemorrhagic Shock in the Rat

“…This process correlates to the intravital microscopic observation of slow rolling (3). Irreversible adhesion and migration of leukocytes into the interstitium involves integrins CD11a/CD18 (LFA-1), CD11b/CD18 (Mac-1), and CD11c/CD18 (p150/95) on leukocytes and integrins intercellular adhesion molecule (ICAM)-1 and ICAM-2 on endothelial cells (4,5).…”

Attenuation of Ischemic Injury by N-Acetylcysteine Preconditioning of the Liver

“…With pharmacological preconditioning, liver protection is achieved by the administration of substances before or at the early phases of the I/R process. Prime examples of pharmacological preconditioning are the maintenance of adenosine bioavailability with dipiridamole [6], the enhancement of tissue cAMP levels by phosphodiesterase inhibitors [9,37], the improvement of hepatic microcirculation with L-arginine (a NO precursor) [25], the use of monoclonal antibodies against noxious sub- stances or their receptors [38,39], and the enhancement of antioxidant capacity with augmentation of free radical scavengers [40].…”

An in vivo approach showing the chemotactic activity of leukotriene B 4 in acute renal ischemic-reperfusion injury

“…Recent studies have addressed the role of PMNs as mediators of radical-based injury during ischemia reperfusion or preservation reperfusion of various tissues (18)(19)(20). Sequestered and activated neutrophils release lysosomal hydrolytic enzymes, lipid mediators, and reactive oxygen species that protect against invading organisms and help remove dead cells but also damage surrounding viable tissues.…”