Protective effect of melatonin on contractile activity and oxidative injury induced by ischemia and reperfusion of rat ileum

Özaçmak, Veysel Haktan; Sayan, Hale; Arslan, Seyfullah Oktay; Altaner, Semsi; Aktaş, Ranan Gülhan

doi:10.1016/j.lfs.2004.08.031

Cited by 51 publications

(35 citation statements)

References 39 publications

(92 reference statements)

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“…Decreased contractile response observed also in non-receptor-mediated induction supports the possibility that ischemia/reperfusion may not alter the ligand-receptor interaction but rather changes the regulation of postreceptor processes (i.e. excitation-contraction coupling) (19). Our data are consistent with these fi ndings.…”

Section: Discussionsupporting

confidence: 91%

Role of curcumin in mesenteric ischemia – reperfusion injury in rats

Okudan²,

Belviranlı³

et al. 2012

BLL

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Abstract:Background: Curcumin is an antioxidant molecule that has been shown to attenuate ischemia/reperfusion (I/R) injury in several organ systems. In the present study, we aimed to evaluate the possible effects of curcumin on contractile response to agonists and histopathological alterations in rat esophagus subjected to mesenteric I/R. Materials and methods: Adult male Wistar albino rats were randomly allocated to 4 groups, namely group I: sham-operated animals (n=10); group II: animals subdued to I/R injury only (n=10) and laparotomy; 45 minutes of superior mesenteric artery ligation were followed by 2 hours of reperfusion, group III: curcumin/sham (n=10); 20 days before I/R, curcumin (200 mg/kg/) was administered by gastric gavage, and group IV: curcumin-I/R (n=10). Mesenteric ischemia/reperfusion model was generated by clamping the superior mesenteric artery for 45 min followed by reperfusion for 2 h. Oral administration of curcumin by gavage at a dose of 200 mg/kg/day lasted 20 days just before inducing the mesenteric ischemia. At the end of reperfusion period, all animals were sacrifi ced and esophagus samples were collected to assess the contractile response to agonists and histopathological alterations. Results: Ischemia/reperfusion signifi cantly decreased the contractile responses to carbachol and KCl and this decrease was attenuated by curcumin. Pretreatment with curcumin caused a remarkable decrease in histopathological parameters such as edema, congestion and infl ammatory cells. Conclusions:The results of the present study demonstrate for the fi rst time that curcumin can attenuate the esophageal injury associated with I/R (Tab. 4, Fig. 3, Ref. 32). Full Text in PDF www.elis.sk.

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Section: Discussionsupporting

confidence: 91%

Role of curcumin in mesenteric ischemia – reperfusion injury in rats

Okudan²,

Belviranlı³

et al. 2012

BLL

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“…Glutathione precursors are protective for different types of free radical-mediated cellular injury [9]. Published studies have demonstrated that intestinal I/R depletes tissue GSH [42]; therefore, the decreased GSH content in lung tissue from the I/R group seems to be the result of oxidant injury. Pretreatment with Sp increased the GSH levels almost to sham control levels; thus, Sp pretreatment provides a significant protective effect against I/R-induced lipid peroxidation.…”

Section: Discussionmentioning

confidence: 99%

Reduction of Acute Lung Injury by Administration of Spironolactone After Intestinal Ischemia and Reperfusion in Rats

Barut¹,

Özaçmak²,

TURAN³

et al. 2016

CIM

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Purpose: Multiple organ failure, including acute lung injury, is a common complication of intestinal ischemia and reperfusion (I/R) injury and contributes to its high mortality rate. Activated polymorphonuclear neutrophils and reactive oxygen species contribute to the lung injury caused by intestinal I/R. Mineralokortikoid receptor antagonist spironolactone has a protective effect against I/R injury in animal models of retina, kidney, heart, and brain. The aim of the present study is to investigate the effect of aldosteron receptor blocker spironolactone on lung injury induced by intestinal I/R.Methods: Wistar albino rats were divided into four groups: (1) sham control; (2) intestinal I/R (30 min of ischemia by superior mesenteric artery occlusion followed by 3 h of reperfusion); (3) spironolactone pretreatment (20 mg/kg) + I/R; and, (4) spironolactone pretreatment without I/R. Spironolactone was given orally 3 days prior to intestinal I/R. A marker for lipid peroxidation (malondialdehyde; MDA), an indicator or oxidation state (reduced glutathione; GSH), an index of polymorphonuclear neutrophil sequestration (myeloperoxidase; MPO), inducible nitric oxide synthase (iNOS) immunoreactivity, and the histopathology of the lung tissue were analyzed.Results: Spironolactone pretreatment markedly reduced intestinal I/R-induced lung injury as indicated by histology and MDA and MPO levels. Moreover, the pretreatment decreased the iNOS immunoreactivity. Conclusion:The present study strongly suggests that spironolactone pretreatment decreased neutrophil infiltration, iNOS induction, oxidative stress, and histopathological injury in an experimental model of intestinal I/R induced-lung injury of rats.

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“…Antioxidant is a molecule that prevents the oxidation of other molecules. Antioxidants protect cells from the dangers of free radicals by destroy free radicals and inhibit other oxidation reactions [5,[10][11][12][13]. The key enzymes defense system include superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), nitric oxide (NO) and paraoxonase (POX) [5,[10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

“…Each enzyme has a unique function. Superoxide anions, first derivative of free radicals, convert by SOD into water and oxygen [5,[10][11][12][13]. Glutathione, the major nonprotein thiol in aerobic organisms, is abundant intracellular non-enzymatic antioxidant.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Selenium on Antioxidant Activity and Recovery From Sciatic Nerve Ischemia–Reperfusion in Adult Rats

Zendedel

Delavari

Ahmadvand

et al. 2015

Zahedan J Res Med Sci

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Background: Selenium is an antioxidant trace element that is capable protects various tissues against damage induced by ischemiareperfusion injury. Objectives: This study examines the selenium effect on antioxidant activity and recovery from sciatic nerve ischemia-reperfusion in adult rats. Materials and Methods:In this experimental study, 80 adult male Wistar rats weighing 250 -300 g were used. They were divided into ten groups (n = 8 per group). The first group received sham surgery only. The second group received 0.2 mg/kg selenium without ischemiareperfusion surgery and eight remaining groups were divided to four control groups and four experimental groups which the latter groups received 0.2 mg/kg selenium. All ischemia groups were rendered in ischemic for 3 hours and reperfused for various times of 3, 7, 14 and 28 days. Half of the groups had experimental selenium (0.2 mg/kg) intraperitoneal injection treatment immediately after ischemia. According to a schedule for each group of rats bled and then centrifuged, and serum was prepared for assessment of activity levels of glutathione peroxidase (GPX), catalase (CAT), nitric oxide (NO), paraoxonase (POX), and malondialdehyde (MDA). Results: Comparison of the serum GPX, CAT, NO, POX, and MDA levels in the groups that received selenium with corresponding control group showed that selenium can increase plasma activity levels of GPX, POX and decrease activity levels of NO. Conclusions: Selenium with decreased activity levels of NO and increased activity GPX and POX can decrease ischemia-reperfusion injury in lower limb especially sciatic nerve.

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Protective effect of melatonin on contractile activity and oxidative injury induced by ischemia and reperfusion of rat ileum

Cited by 51 publications

References 39 publications

Role of curcumin in mesenteric ischemia – reperfusion injury in rats

Role of curcumin in mesenteric ischemia – reperfusion injury in rats

Reduction of Acute Lung Injury by Administration of Spironolactone After Intestinal Ischemia and Reperfusion in Rats

Effects of Selenium on Antioxidant Activity and Recovery From Sciatic Nerve Ischemia–Reperfusion in Adult Rats

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