Protective effect of melatonin against oxidative stress on adhesion formation in the rat cecum and uterine horn model

Ara, Cengiz; Kırımlıoğlu, Hale; Karabulut, Aysun Bay; Çoban, Sacit; Hasçalık, Şeyma; Çelik, Önder; Yilmaz, Sezai; Kırımlıoğlu, Vedat

doi:10.1016/j.lfs.2005.01.024

Cited by 37 publications

(39 citation statements)

References 35 publications

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“…In the present study, the level of tissue NO increased (p<0.01) significantly in C group when compared with Sh group. This indicates that adhesion formation may lead to the induction of inducible nitric oxide synthase, resulting in an increased production of nitric oxide 24,25 . Also, NO level decreased significantly in VE groups when compared with C groups in the present study.…”

Section: Discussionmentioning

confidence: 99%

“…This result suggests that VE blocks the occurrence of NO and therefore it has a supportive effect on the antioxidant system. It was reported that intraperitoneal administration of melatonin 24 and resveratrol 25 decreases the incidence and extent of peritoneal adhesions and causes a decrease in NO values. Gurel et al 26 reported that administration of VE decreased NO concentrations in both ipsilateral and contralateral renal tissues compared to ischemia-reperfusion group.…”

Section: Discussionmentioning

confidence: 99%

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The comparison of methylene blue and vitamin E in prevention of abdominal postoperative adhesion formation in rat uterine horn models: Biochemical and histopathologic evaluation

et al. 2011

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Comparação do azul de metileno e vitamina E na prevenção de aderência abdominal pós-operatória em corno uterino de ratos. Avalição bioquímica e histopatológica ABSTRACT Purpose:To compare the effects of vitamin E and 1% methylen blue solutions on prevention of experimentally induced adhesions in rats. Methods: Thirty seven female Spraque Dawley rats were randomized into four groups. First group was kept as sham operated group. An adhesion model was constituted on the left uterine horn of the other groups. The lesion areas of rats from the second, the third and the fourth groups were coated with 2 ml 0.9 % saline solution (C group), 10 mg vitamin E (VE group) and 1% methylen blue solutions (MB group), respectively. Results: Histopathologically, adhesion scores, mononuclear cell infiltration, oedema and fibrosis were more prominent in the MB group compared with C and VE groups. There were no significant differences between the groups in tissue glutathione peroxidase (GPx), catalase (CAT) activities and glutation (GSH) level, these parameters were slightly increased in group with VE supplementation though. The administration of VE and MB significantly decreased NO (P<0.01) levels when compared to the C group. The level of malondialdehyde (MDA) in the VE group was significantly lower (P<0.05) than those of the Sh and C groups. Conclusion: Intraperitoneal methylen blue solutions treatments were more effective according to vitamin E in preventing the formation of intra-abdominal adhesion in a rat uterine horn model. Key words: Vitamin E. Methylene Blue. Tissue Adhesions. Uterus. Rats. RESUMO Objetivo:Comparar os efeitos da vitamina E e 1% da solução de azul de metileno na prevenção de aderências induzidas em ratos. Métodos: Trinta e sete ratos fêmeas Spraque Dawley foram distribuídos em quatro grupos. O primeiro grupo foi mantido como grupo sham. O modelo de aderência foi realizado no corno uterino esquerdo nos outros grupos. As áreas da lesão dos ratos do segundo, terceiro e quarto grupos foram revestidas com 2 ml de solução salina 0,9% (Grupo C), 10 mg de vitamina E (Grupo VE) e solução de azul de metileno 1% (Grupo MB), respectivamente. Resultados: Histopatologicamente, o escore das aderências, infiltração celular mononuclear, edema e fibrose foram mais proeminentes no grupo MB em comparação aos grupos C e VE. Não houve diferença significante entre os grupos na peroxidase da glutatione do tecido (GPx), atividade da catalase (CAT) e o nível de glutation (GSH). Estes parâmetros foram ligeiramente aumentados no grupo com suplemento da VE. A administração da VE e do MB diminuiu significantemente os níveis quando quando comparada ao Grupo C. O nível de malondialdeído no grupo VE foi significantemente mais baixo do que nos grupos sham e C. Conclusão: A administração intraperitoneal da solução de azul de metileno foi mais eficaz de acordo com a vitamina E na prevenção de aderências intra-abdominais no corno uterino de ratos. Descritores: Vitamina E. Azul de Metileno. Aderências Teciduais. Útero. Ratos. Yildiz H et al 52

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The comparison of methylene blue and vitamin E in prevention of abdominal postoperative adhesion formation in rat uterine horn models: Biochemical and histopathologic evaluation

et al. 2011

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“…In the study of Ten Raa et al (22), it was demonstrated that during peritoneal healing, oxidative stress increases, and there is a positive correlation between the level of oxidative stress and the severity of adhesion. In another study, Ara et al (10) showed that the severity of adhesion increases with oxidative stress. In their study, it was also reported that MDA and nitrite/nitrate values increasing with peritoneal adhesions decreased with melatonin, an antioxidant substance, and hence adhesion decreased as well.…”

Section: Adhesion Region Scorementioning

confidence: 94%

The effect of alpha-lipoic acid in the prevention of peritoneal adhesions

Özler¹,

Ersöz²,

Özerhan³

et al. 2011

Turk J Gastroenterol

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“…Accumulation of free radicals may result in more collagen synthesis through fibrogenic processes such as transforming growth factor beta (TGF-β) activation and lipid peroxidation [107]. A positive correlation between oxidative stress and the severity of peritoneal adhesions has been demonstrated [108]. It has been also known that endometriosis, another risk factor for pelvic adhesion, is closely associated with endometriosis [6].…”

Section: Oxidative Stress and Pelvic Adhesionsmentioning

confidence: 99%

“…It has been reported that antioxidants such as methylene blue, melatonin, vitamin E, and alpha lipoic acid were able to decrease peritoneal adhesions [108,109]. Peritoneal TAC scavenges free radicals and protects peritoneal tissue from oxidative damage.…”

Section: Oxidative Stress and Pelvic Adhesionsmentioning

confidence: 99%

Oxidative Stress in Unexplained Female Infertility

Verit

2015

Unexplained Infertility

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Protective effect of melatonin against oxidative stress on adhesion formation in the rat cecum and uterine horn model

Cited by 37 publications

References 35 publications

The comparison of methylene blue and vitamin E in prevention of abdominal postoperative adhesion formation in rat uterine horn models: Biochemical and histopathologic evaluation

The comparison of methylene blue and vitamin E in prevention of abdominal postoperative adhesion formation in rat uterine horn models: Biochemical and histopathologic evaluation

The effect of alpha-lipoic acid in the prevention of peritoneal adhesions

Oxidative Stress in Unexplained Female Infertility

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