Protective Effect of Melatonin Against Ischemia/Reperfusion-Induced Oxidative Remote Organ Injury in the Rat

Abstract

Since melatonin administration reversed these oxidant responses, it seems likely that melatonin has a protective effect against oxidative organ damage induced by I/R.

Beneficial effects of rutin andl-arginine coadministration in a rat model of liver ischemia-reperfusion injury

“…These data are consistent with previous observations reporting a significant difference in RSH levels between control and I/R groups (18). Glutathione provides major protection in oxidative injury by participating in a cellular system of defense against oxidative damage.…”

“…Consistent with previous observations, results obtained in the present study confirm that plasmatic and hepatic LOOH levels significantly increase in postischemic reperfusion (18). Our results also demonstrate that rutin and L-arginine cause a significant decrease in LOOH levels, suggesting that the protective effect of these drugs may be due, in part, to their scavenger capacity (32,33).…”

“…It has been suggested that I/R triggers a series of reactions mainly in the organ that is clamped and reperfused, and these reactions elicit a systemic inflammatory response by the release of cytokines and inflammatory mediators (tumor necrosis factor-␣, interleukin-6, platelet-activating factor, leukotrienes, and NO) that cause the formation of oxygen ROS with consequent oxidative stress (8,13,18,45). In this regard, several studies have demonstrated that I/R is associated with protein oxidative modifications, mitochondrial injury, and lipid peroxidation; this last is an autocatalytic mechanism leading to oxidative destruction of the cellular membranes that, in turn, can lead to the production of toxic, reactive metabolites and cell death (18). However, at present there is no treatment available to prevent hepatic I/R injury, and even then, only a better comprehension of mechanisms of hepatic I/R injury could improve orthotopic liver transplantation results.…”

The Antioxidant Effect of Melatonin on Myocardial Ischemia Reperfusion Injury in Experimental Studies

“…Neutrophil-specific enzyme, MPO, activity can be assessed during I/R and can be commented. In some studies, it had been indicated that reperfusion causes higher enzyme activity then ischemia [28,29].…”

Possible Protective Effect of Bone Marrow-Mesenchymal Stem Cells (BM-MSCs) Against the Remote Liver Injury Induced by Renal Ischemia Reperfusion in Male Albino Rats

“…The increasing mortality rate in cases with acute renal injury necessitates designing strategies to assess the effect of renal injury on distant organs [11]. Therefore, several studies [8,[1][2][3][4][5][6][7][8][9][10][11][12][13][14] tried to protect liver from remote injury induced by renal IRI for the prevention and attenuation of acute renal injury related morbidity.…”