Protective effect of maghemite nanoparticles on ultraviolet-induced photo-damage in human skin fibroblasts

Abstract

This study examined the optical properties of an oxidized form of maghemite (γ-Fe(2)O(3)) nanoparticles and their protective effects against the photoaging of human skin fibroblasts irradiated with ultraviolet (UV) light. Nanoparticles with diameters ranging from 8.7 to 12 nm were prepared using a chemical co-precipitation method. The nanoparticles were coated with two surfactants to obtain a water-based product. The onset of the absorption of the γ-Fe(2)O(3) nanoparticles in the UV-visible absorption spectra increased with increasing particle size. The γ-Fe(2)O(3) nanoparticles significantly inhibited the production of matrix metalloproteinase-1 in human skin fibroblast HS 68 cells by 60% compared with the UV-irradiated control. These results suggest that γ-Fe(2)O(3) nanoparticles have photoprotective properties, and have potential use as an agent against photoaging.

Comparison between antibacterial activity of some natural dyes and silver nanoparticles

“…HaCaT cells treated with 10 and 100 μg mL −1 of S-AgNPs had 47.8% and 53.3% levels of MMP-1 secretion, respectively. Our result is in line with the previous research which showed the inhibitory effect of maghemite nanoparticles on MMP-1 secretion [33].…”

“…Recently, nanoparticles synthesized from the medicinal plant have been widely reported for their anti-inflammatory, anti-cancer, anti-oxidant and antimicrobial effects [11,31,32]. There are very few studies showing the effect of nanoparticles on photoaging for e.g., Lee et al [33] reported the effect of maghemite nanoparticles in protection against ultraviolet-induced photo damage in human skin fibroblasts. Solid lipid nanoparticles of N-6-furfuryl adenine has been reported for the protective effect against photoaging [34].…”

Fe2+: Fe3+ Molar Ratio Influences the Immunomodulatory Properties of Maghemite (γ-Fe2O3) Nanoparticles in an Atopic Dermatitis Model

“…XRD spectra indicated γ-Fe 2 O 3 in the iron oxide samples with the Fe 2+ : Fe 3+ ratios: 1: 1, 1: 2, 2: 3. 24 Thus, some differences were observed between the physical and optical properties of FM1, FM2, and FM3. The objectives of the study was to determine whether the initial molar ratio of Fe 2+ : Fe 3+ induces variations in the γ-Fe 2 O 3 NPs antioxidant properties.…”

“…The γ-Fe 2 O 3 NP samples were synthesized by adjusting Fe 2+ : Fe 3+ molar ratio as 1: 1, 1: 2, or 2: 3. 24 Antioxidant Effect of FM1, FM2, and FM3 Nanoparticles. The antioxidant activity of nanoparticles (10 mg/mL) was assessed by the DPPH method for insoluble solid materials, such as iron oxide particles, as described by Paul et al 37 The positive control was used as ascorbic acid (10 μg/mL) and the DPPH activity was calculated by following eq 1:…”

“…23 Interestingly, variation in the Fe 2+ : Fe 3+ initial molar ratio ranging from 1: 1 to 1: 2 has also been reported in γ-Fe 2 O 3 NPs synthesis. 24 In addition, in the atmosphere, coprecipitation from different Fe 2+ : Fe 3+ initial molar ratios lead preferentially to γ-Fe 2 O 3 instead of Fe 3 O 4 because the molar ratio of Fe 2+ : Fe 3+ changes. 23 Thus, studies have deeply investigated the physical and chemical changes that occur in iron oxide nanoparticles, which are associated with the variation of the Fe 2+ : Fe 3+ molar ratio in the coprecipitation method.…”