Protective effect of lycopene against chemical and natural toxins: A review

Abstract

People are exposed to a number of environmental, occupational, and therapeutic toxic agents which may be natural or man made. These hazardous substances may manifest as direct side effects on the function of organs or indirectly induced alteration of gene expression, cancer‐associated metabolic pathways, and/or alter homeostasis. Lycopene, as a one of the most potent antioxidant, is found in fruits and vegetables. High‐intake of lycopene has been shown to be effective in decreasing the risk of both natural toxins including mycotoxins, bacterial toxins, and chemical toxins including heavy metals, pesticides as well as herbicides. Recently, there is growing attention in understanding the mechanisms of the phytochemicals and carotenoids as antioxidative, antiapoptotic, radical scavenging, and chelating agents and their roles in the modulation of inflammatory pathways. This review summarizes available data from several recent studies about lycopene and its role against chemical and natural toxicants. © 2018 BioFactors, 45(1):5–23, 2019

Protective Effect of Lycopene against Reperfusion Injury in Rats with Ovarian Torsion: A Biochemical and Histopathological Evaluation

“…25 It has been commonly used as an antioxidant agent in traditional medicine and has been reported to have protective effects for the treatment of cardiovascular diseases, neurotoxicity, hepatic injury, and nephrotoxicity. 26 Acetaminophen overdoses are causes of hepatic necrosis and acute liver failure. 27 It has been reported that lycopene defends against acetaminophen-induced liver injury in mice by increasing antioxidant substances including GSH.…”

The use of plant extracts and their phytochemicals for control of toxigenic fungi and mycotoxins

“…(2013) ; Wu et al. (2017a) ; Hedayati et al. (2018) Cyanidin In vitro HepG2 & Caco-2 cells Protected against AFB 1 & OTA-induced oxidative stress Sorrenti et al.…”

“…Lycopene also prevented T-2 toxin-induced oxidative stress and maintained GSH cellular levels in vivo ( Leal et al., 1999 ). Furthermore, lycopene reduced AFB 1 and OTA-induced oxidative stress and apoptosis in rats ( Hedayati et al., 2018 ). Cyanidin, a phytochemical found in various medicinal herbs, fruits and vegetables including grapes, blackberry, cherry, cranberry, raspberry, red cabbage, red onion, etc., showed a protective effect against AFB 1 and OTA-induced toxicity in hepatocytes and enterocytes ( Sorrenti et al., 2012 ).…”

The neuroprotective activities of natural products through the Nrf2 upregulation

“…Paeonia lactiflora (Ma et al, ), Panax ginseng (Bak et al, ), and Coffea arabica (Cavin et al, ) are examples of such herbs. Apigenin (a flavonoid in some Apiaceae herbs; Sang et al, ), galangin (found in some Zingiberaceae rhizomes; Huang et al, ), glycybridin A & G ( Glycyrrhiza glabra ; K. Li et al, ), lycopene (Hedayati et al, ), and cyanidin (an anthocyanin found in different berry fruits; De Pascual‐Teresa, ) are a few examples of natural substances that have been reported to interact with Nrf2, potentially presenting health promoting properties.…”

“…Paeonia lactiflora , Panax ginseng (Bak et al, 2016), and Coffea arabica (Cavin et al, 2008) are examples of such herbs. Apigenin (a flavonoid in some Apiaceae herbs; Sang et al, 2017), galangin (found in some Zingiberaceae rhizomes; Huang et al, 2017), glycybridin A & G (Glycyrrhiza glabra; K. , lycopene (Hedayati et al, 2019), and cyanidin (an anthocyanin found in different berry fruits;…”