Protective Effect of Lycium ruthenicum Murr. Against Radiation Injury in Mice

Duan, Yabin; Chen, Fan; Yao, Xingchen; Zhu, Junbo; Cai, Wei; Zhang, Juanling; Li, Xiangyang

doi:10.3390/ijerph120708332

Cited by 50 publications

(34 citation statements)

References 29 publications

(29 reference statements)

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“…All rats, except the control groups, were restrained in special boxes and exposed to 1 or 5 Gy whole‐body X‐ray irradiation from a medical electronic linear accelerator (23EX; Varian, Palo Alto, CA, USA). The source‐to‐animal distance was 100 cm, and the irradiation time was 100 s. The reason for the use of 1 and 5 Gy for the rats was to simulate the relevant dosage range for the daily treatment of the human torso, for safety and workability, as described in our previous report .…”

Section: Methodsmentioning

confidence: 99%

“…Although the prevention and treatment of irradiation damage and the efficacy of drugs have been studied , there are only a few reports on pharmacologic and pharmacokinetic changes. The physiologic changes after exposure to irradiation may alter drug pharmacokinetics that, in turn, might require modification to dosage regimens to maintain efficacy or prevent toxicity.…”

Section: Introductionmentioning

confidence: 99%

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Effect of X‐ray irradiation on pharmacokinetics of irinotecan hydrochloride and expression of CES1 and CYP3A1 in rats

Qiao

Wang

Xin

et al. 2019

Fundamemntal Clinical Pharma

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Concurrent chemoradiation with irinotecan hydrochloride (CPT‐11) is accepted for cancer treatment. However, the effects of X‐ray irradiation on chemotherapeutics in the plasma remain unclear. We evaluated the pharmacokinetics of CPT‐11 in rats after exposure to X‐ray irradiation and examined the changes of protein and mRNA expression of CES1 and CYP3A1. The X‐ray irradiation with 1 Gy and 5 Gy was delivered to the whole body of rats. CPT‐11 at 30 and 60 mg/kg, respectively, was intravenously infused 24 h after irradiation. CPT‐11 was determined by RP‐HPLC in plasma. ELISA and PCR were used to analyze the protein and mRNA expression of CES1 and CYP3A1, respectively. Compared with control rats, the X‐ray irradiation decreased the AUC of CPT‐11 (30 mg/kg) by 15.6% at 1 Gy and 39.0% at 5 Gy and increased the CL by 60.0% at 5 Gy. The X‐ray irradiation could also decrease the AUC of CPT‐11 (60 mg/kg) and increase the CL. In addition, the protein and mRNA expression of CES1 and CYP3A1 were increased significantly in rats after irradiation. This study found significant changes in the pharmacokinetics of CPT‐11 in rats after exposure to X‐ray irradiation, and they might be due to significant increases in the expressions of CYP3A1 and CES1. The pharmacokinetics of CPT‐11 should be rechecked, and the optimal CPT‐11 dose should be reevaluated during concurrent chemoradiation therapy.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of X‐ray irradiation on pharmacokinetics of irinotecan hydrochloride and expression of CES1 and CYP3A1 in rats

Qiao

Wang

Xin

et al. 2019

Fundamemntal Clinical Pharma

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“…Anthocyanins as natural pigments can be applied in the food industry as they have a high color rendering capacity and a low toxicity (Fernandes et al., ). Moreover, they also show many biological activities, such as antioxidant (Wang, Li et al., ), antitumor (Fragoso et al., ), antiaterosclerotic (Yamakoshi, Kataoka, Koga, & Ariga, ), antiatherosclerosis (Lin, Jin, Haiying, Yuting, & Qian, ), and against radiation injury activities (Duan et al., ). However, the extraction of anthocyanins is challenging because of their low chemical stabilities (Pedro, Granato, & Rosso, ).…”

Section: Introductionmentioning

confidence: 99%

“…It is a famous traditional herb recorded in many Chinese medical monographs, such as "Si Bu Yao Dian" and "Jing Zhu Ben Cao." Besides, L. ruthenicum fruits contain abundant bioactive compounds, such as flavonoids, polysaccharides, and anthocyanins (Zhang et al, 2016), which have the pharmacological activities of antioxidation (Liu et al, 2013), antiradiation (Duan et al, 2015), immune enhancement (Gong, Wu, & Li, 2015), and antitumor (Zhang, He, Chen, & Ding, 2019).…”

Section: Introductionmentioning

confidence: 99%

Extraction optimization and purification of anthocyanins from Lycium ruthenicum Murr. and evaluation of tyrosinase inhibitory activity of the anthocyanins

Shen

Liu

Liang

et al. 2020

Journal of Food Science

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The aim of this study was to extract and purify anthocyanins from Lycium ruthenicum Murr. and evaluate their tyrosinase inhibitory activity. Response surface methodology was devoted to optimize enzyme‐assisted extraction of anthocyanins from L. ruthenicum dried fruits. Extraction at 38 °C for 37 min using water‐containing pectinase (52.04 mg/100 g dried fruit) rendered an anthocyanin extraction yield of 19.51 ± 0.21 mg/g. The purified anthocyanins were separated from the extract by macroporous resin XDA‐6. Antioxidant tests in vitro suggested that the extract and the purified anthocyanins exhibited a potent 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) radical scavenging capacity, 2,2‐azino‐bis‐3‐ethylbenzothiazoline‐6‐sulfonic acid (ABTS) radical scavenging capacity, hydroxyl radical scavenging capacity, superoxide radical scavenging capacity, and total reducing power. Thirteen anthocyanins from L. ruthenicum dried fruits were analyzed by HPLC‐MS. Moreover, the purified anthocyanins had inhibitory effect on tyrosinase monophenolase (IC50 = 1.483 ± 0.058 mg/mL), and the type of inhibition was competitive inhibition (Ki = 39.83 ± 1.4 mg/mL). The maximum inhibitory activity of the purified anthocyanins (3.00 mg/mL) on tyrosinase diphenolase was 42.16 ± 0.77%, and the type of inhibition was anticompetitive inhibition (Kis = 2.387 ± 0.10 mg/mL). Practical Application The anthocyanins from L. ruthenicum dried fruits can be used as tyrosinase inhibitors in medicine, cosmetics, and food preservation industries.

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“…Lycium ruthenicum (Russian box thorn or black wolfberry), a very close relative of L. barbarum and L. chinense 7 , is a wild perennial thorny shrub native to Northwest China, whose resistance to the harsh environment of saline deserts makes it a popular choice plant for combating soil desertification and for alleviating soil salinity/alkalinity 8,9 . It is also used in the local folk medicine and as food 8 , and studies indicate that it has notable pharmaceutical effects 9,10 . As these two species, and their fruits, are referred to by a range of (often overlapping) names 1 , to avoid confusion we refer to the fruit of L. barbarum (LB) as red wolfberry, and fruit of L. ruthenicum (LR) as black wolfberry.…”

mentioning

confidence: 99%

Transcriptomic and metabolomic analyses of Lycium ruthenicum and Lycium barbarum fruits during ripening

Zhao

Yin

et al. 2020

Sci Rep

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Red wolfberry (or goji berry, Lycium barbarum; LB) is an important agricultural product with a high content of pharmacologically important secondary metabolites such as phenylpropanoids. A close relative, black wolfberry (L. ruthenicum; LR), endemic to the salinized deserts of northwestern china, is used only locally. The two fruits exhibit many morphological and phytochemical differences, but genetic mechanisms underlying them remain poorly explored. in order to identify the genes of interest for further studies, we studied transcriptomic (Illumina HiSeq) and metabolomic (LC-MS) profiles of the two fruits during five developmental stages (young to ripe). As expected, we identified much higher numbers of significantly differentially regulated genes (DEGs) than metabolites. The highest numbers were identified in pairwise comparisons including the first stage for both species, but total numbers were consistently somewhat lower for the LR. The number of differentially regulated metabolites in pairwise comparisons of developmental stages varied from 66 (stages 3 vs 4) to 133 (stages 2 vs 5) in both species. We identified a number of genes (e.g. AAT1, metE, pip) and metabolites (e.g. rutin, raffinose, galactinol, trehalose, citrulline and DL-arginine) that may be of interest to future functional studies of stress adaptation in plants. As LB is also highly suitable for combating soil desertification and alleviating soil salinity/alkalinity/pollution, its potential for human use may be much wider than its current, highly localized, relevance.Despite their close phylogenetic relationship, the fruits of these two species exhibit distinct phenotypic profiles of during all developmental stages, including their shape, size, colour, taste, nutritional value and pharmacological properties 3,4,11 . As opposed to the red and elongated mature red wolfberry, black wolfberry is dark-purple or black, round, and smaller. It is also known that metabolic phenotypes of these two fruits differ significantly, particularly in the content of fatty acids, phenols and antioxidant capacities, which are much higher in black wolfberry, while the content of carotenoids, sugars, amino acids and osmolytes is higher in the red wolfberry 3,4 .Fruit ripening is a complex developmental process, coordinated by a network of interacting genes and signalling pathways 12 , so genetic mechanisms underpinning these phenotypic differences remain only partially understood. The objective of this study was to contribute to our understanding of the complexity of ripening processes of these two fruits in different environments. To achieve this, we collected L. barbarum and L. ruthenicum fruits at five developmental stages, from young to ripe fruit, and sequenced their transcriptomes and metabolomes. These data shall help us better understand genetic underpinnings of both within-and between-species phenotypic differences that fruits of these two species exhibit during their respective ripening processes. Materials and methodsSample collection. Fruits were collected ...

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Protective Effect of Lycium ruthenicum Murr. Against Radiation Injury in Mice

Cited by 50 publications

References 29 publications

Effect of X‐ray irradiation on pharmacokinetics of irinotecan hydrochloride and expression of CES1 and CYP3A1 in rats

Effect of X‐ray irradiation on pharmacokinetics of irinotecan hydrochloride and expression of CES1 and CYP3A1 in rats

Extraction optimization and purification of anthocyanins from Lycium ruthenicum Murr. and evaluation of tyrosinase inhibitory activity of the anthocyanins

Transcriptomic and metabolomic analyses of Lycium ruthenicum and Lycium barbarum fruits during ripening

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