Protective effect of Kumquat fruits and carrot seeds extracts against brain aging in rats

Abstract

Introduction: Protection of brain against accelerated aging helps avoiding the occurrence of neurodegenerative diseases. So, the current work was conducted to evaluate the rescuing role of kumquat fruits crude ethanol extract, carrot seeds ethanol and petroleum ether extracts against the brain aging induced by D-galactose in rats. Methods: Forty male Sprague Dawley rats were divided equally into five groups. Group I was served as normal control, rats of group II were daily injected intraperitoneally (i.p.) with 150 mg/kg BW of D-galactose. Rats of group III, IV and V were daily injected i.p. with the same dose of D-galactose and administered orally with 250 mg/kg BW/day of kumquat fruits crude ethanol extract, carrot seeds ethanol extract and carrot seeds petroleum ether extract, respectively. After 6 weeks the rats were scarified, brain tissues were analyzed for malondialdehyde (MDA), catalase (CAT) as well as histological examination. Also, the plasma was analyzed for MDA, tumor necrosis factor-α (TNF-α), creatinine and urea levels, as well as CAT, butyrylcholinesterase (BChE), aspartate transaminase (AST) and alanine transaminase (ALT) activities. Results: From the results, it was elucidated that the tested extracts suppressed both the reduction in CAT and the elevation in MDA either in brain or plasma and the increase in plasma TNF-α, BChE as well as liver and kidney parameters. Conclusion: The tested extracts can be served as potent protective agents against the accelerated aging parameters which may be due to anti-oxidant and anti-inflammatory activities.

Comparative Study between Saffron (Crocus sativus L.) and / or Turmeric (Curcuma longa L.) Extracts on D-galactose Deleterious Brain Effects in Rats

“…These results were similar to Yellamma [88] Sun et al [89] Mohamed et al [90] and Rusu et al [91] who reported that D-galactose caused severe structural damage, such as necrosis and apoptosis with a decline in the number of surviving neurons in the cortex and hippocampus of D-galactose rats compared to normal control rats .D-galactose decreased the neural cell density. On the other hand saffron and turmeric extracts antioxidants, polyphenols and active constituents preserved brain structure from Dgalactose degeneration.…”

التأثير الوقائي لمستخلص فاکهة الکمکوات الإيثانولي ضد تسمم الکبد الناتج عن الکاربيندازيم في الفئران

“…These results had the same trend of one study (47) who showed that natural products such as kumquat have been shown to have a protective effect on blood sugar levels in diabetic rats. Researchers found that serum creatinine and urea were lowered in rats treated with kumquat crude ethanol extract by 33.3% and 13.35% respectively (48). Administration rats with 100 and 200 mg/kg of B.W of EEK did not differ (p > 0.05) in their effect on creatinine.…”

Effect of dried kiwi and kumquat fruits against azathioprine induced liver toxicity in male albino rats

“…Matsuo et al, (2014) showed that the production of SOD decreased dramatically as the result of administration with AZA. Mohamed et al, (2019) reported that administration of kumquat fruits suppressed MDA elevation and increased CAT level .Feeding on kumquat fruit suppressed MDA exhibited the highest levels of TNF-α . The improvement of SOD, CAT and MDA return to the treatment with the tested fruits may be due to their content from ascorbic acid (Boland, 2013).…”