Protective effect of Korean Red Ginseng against chemotherapeutic drug-induced premature catagen development assessed with human hair follicle organ culture model

Keum, Dong In; Pi, Long-Quan; Hwang, Sungjoo; Lee, Won Soo

doi:10.1016/j.jgr.2015.07.004

Cited by 25 publications

(20 citation statements)

References 48 publications

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“…In chemotherapy-induced alopecia, KRG protects against premature catagen development through modulation of p53 and Bax/Bcl2 expression. Finally, ginseng exerts mitogenic and antiapoptotic effects in outer root sheath keratinocytes [62,63]. Malus pumila Mill.…”

Section: Panax Ginseng Ca Meymentioning

confidence: 99%

Protective Role of Nutritional Plants Containing Flavonoids in Hair Follicle Disruption: A Review

Bassino

Gasparri

Munaron

2020

IJMS

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Hair loss is a disorder in which the hair falls out from skin areas such as the scalp and the body. Several studies suggest the use of herbal medicine to treat related disorders, including alopecia. Dermal microcirculation is essential for hair maintenance, and an insufficient blood supply can lead to hair follicles (HF) diseases. This work aims to provide an insight into the ethnohistorical records of some nutritional compounds containing flavonoids for their potential beneficial features in repairing or recovering from hair follicle disruption. We started from a query for “alopecia” OR “hair loss” AND “Panax ginseng C.A. Mey.“ (or other six botanicals) terms included in Pubmed and Web of Sciences articles. The activities of seven common botanicals introduced with diet (Panax ginseng C.A. Mey., Malus pumila Mill cultivar Annurca, Coffea arabica, Allium sativum L., Camellia sinensis (L.) Kuntze, Rosmarinum officinalis L., Capsicum annum L.) are discussed, which are believed to reduce the rate of hair loss or stimulate new hair growth. In this review, we pay our attention on the molecular mechanisms underlying the bioactivity of the aforementioned nutritional compounds in vivo, ex vivo and in vitro studies. There is a need for systematic evaluation of the most commonly used plants to confirm their anti-hair loss power, identify possible mechanisms of action, and recommend their best adoption.

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Section: Panax Ginseng Ca Meymentioning

confidence: 99%

Protective Role of Nutritional Plants Containing Flavonoids in Hair Follicle Disruption: A Review

Bassino

Gasparri

Munaron

2020

IJMS

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“…There has been mounting evidence suggesting that ginseng and its major bioactive constituents, ginsenosides, promote hair growth by enhancing proliferation of dermal papilla and preventing hair loss via modulation of various cell-signaling pathways [ 11 , 12 , 13 ]. While the role of 5α-reductase enzyme in the hair-loss process has been well-documented [ 14 , 15 ], the emerging biochemical mechanisms of hair-follicle proliferation and the hair-loss process unravel new targets for designing novel therapeutics for the management of hair loss and alopecia ( Figure 1 ).…”

Section: Biochemical Basis Of Hair-growth Promotion By Ginsengmentioning

confidence: 99%

“…Treatment of FKCs with 4-hydroxycyclophosphamide (4-HC), a metabolite of chemotherapeutic agent cyclophosphamide, attenuated human hair growth, induced premature catagen development, diminished proliferation, and stimulated apoptosis of hair matrix keratinocytes. Pretreatment with KRG protected against 4-HC-induced hair-growth inhibition and premature catagen development partly by blocking 4-HC-induced p53 and Bax/Bcl2 expression [ 13 ].…”

Section: Human Clinical Studiesmentioning

confidence: 99%

Hair-Growth Potential of Ginseng and Its Major Metabolites: A Review on Its Molecular Mechanisms

Choi

2018

IJMS

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The functional aspect of scalp hair is not only to protect from solar radiation and heat/cold exposure but also to contribute to one’s appearance and personality. Progressive hair loss has a cosmetic and social impact. Hair undergoes three stages of hair cycle: the anagen, catagen, and telogen phases. Through cyclical loss and new-hair growth, the number of hairs remains relatively constant. A variety of factors, such as hormones, nutritional status, and exposure to radiations, environmental toxicants, and medications, may affect hair growth. Androgens are the most important of these factors that cause androgenic alopecia. Other forms of hair loss include immunogenic hair loss, that is, alopecia areata. Although a number of therapies, such as finasteride and minoxidil, are approved medications, and a few others (e.g., tofacitinib) are in progress, a wide variety of structurally diverse classes of phytochemicals, including those present in ginseng, have demonstrated hair growth-promoting effects in a large number of preclinical studies. The purpose of this review is to focus on the potential of ginseng and its metabolites on the prevention of hair loss and its underlying mechanisms.

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“…To verify that the antiproliferative effects were due to apoptosis‐inducing activity, we quantified apoptotic cell death in those lung cancer cell lines using TUNEL staining after treatment with pinecone water extract ( Fig. ) . All four human lung cancer cell lines showed a significant increase in TUNEL‐positive cells when treated with the water extract, indicating that the cytotoxic effect is, at least in part, attributable to the induction of apoptotic activity.…”

Section: Resultsmentioning

confidence: 99%

Pinecone of Pinus koraiensis Inducing Apoptosis in Human Lung Cancer Cells by Activating Caspase‐3 and its Chemical Constituents

Lee

Roh

et al. 2017

Chemistry & Biodiversity

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Pinecones from Pinus koraiensisSiebold & Zucc. (Pinaceae), which have historically been treated as an undesired waste by-product in the processing of seeds, have recently been shown to contain ingredients with potent biological activities, such as polyphenols exhibiting antitumor activity. With this study, we seek to broaden our understanding of antitumor compounds contained in these pinecones beyond just polyphenols. We found that the water extract of P. koraiensis pinecones exhibits significant cytotoxic activity, with IC values ranging from 0.62 to 1.73 mg/ml in four human lung cancer cell lines, A549, H1264, H1299, and Calu-6, irrespective of their p53 status. We also demonstrate that pinecone water extract induces apoptosis associated with caspase-3 activation in the same cancer cell lines. Chemical investigation of the pinecone water extract revealed eight main components (1 - 8), and their structures were identified as dehydroabietic acid (1), 15-hydroxy-7-oxodehydroabietic acid (2), 7β,15-dihydroxydehydroabietic acid (3), β-d-glucopyranosyl labda-8(17,13)-diene-(15,16)-lactone-19-oate (4), 7α,15-dihydroxydehydroabietic acid (5), (+)-(1S,2S,4R)-limonene-1,2-diol (6), sobrerol (7), and 4-hydroxybenzoic acid (8). These findings suggest a novel biological application of P. koraiensis pinecones in combatting human lung cancer, and further identify the major compounds that could contribute to this anticancer activity.

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Protective effect of Korean Red Ginseng against chemotherapeutic drug-induced premature catagen development assessed with human hair follicle organ culture model

Cited by 25 publications

References 48 publications

Protective Role of Nutritional Plants Containing Flavonoids in Hair Follicle Disruption: A Review

Protective Role of Nutritional Plants Containing Flavonoids in Hair Follicle Disruption: A Review

Hair-Growth Potential of Ginseng and Its Major Metabolites: A Review on Its Molecular Mechanisms

Pinecone of Pinus koraiensis Inducing Apoptosis in Human Lung Cancer Cells by Activating Caspase‐3 and its Chemical Constituents

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