Protective effect of Juglanin against doxorubicin-induced cognitive impairment in rats: Effect on oxidative, inflammatory and apoptotic machineries

Wei, Tao; Wang, Lei; Tang, Jian; Ashaolu, Tolulope Joshua; Olatunji, Opeyemi Joshua

doi:10.1007/s11011-022-00923-8

Cited by 8 publications

(9 citation statements)

References 41 publications

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“…It has been reported that DOX exposure significantly induces body weight loss, triggers behavioral deficits, and results in depression-like behaviors. Experiment studies showed that treatment with JUG effectively reverses these changes induced by DOX ( Wei et al, 2022 ). Furthermore, Wei et al observed that the levels of SOD, GSH, and CAT were decreased, and the contents of MDA was increased in brain tissues of DOX-treated group, which were subsequently reversed by JUG treatment.…”

Section: Natural Products For the Treatment Of Crcimentioning

confidence: 99%

“…Additionally, studies also indicated the potential benefits of JUG in the alleviation of neuroinflammation via decreasing the expression of TNF-α, IL-6, IL-1β, and NF-KB. In addition, administration of JUG significantly lowered the DOX-elevated AchE activities and caspase-3 activity ( Wei et al, 2022 ). Collectively, all these results suggested that JUG might be a potential drug candidate in the treatment of chemobrain.…”

Section: Natural Products For the Treatment Of Crcimentioning

confidence: 99%

“…In line with these findings, several other studies have also observed similar results in DOX-triggered CRCI models. Additionally, the protective effects of Morin, Juglanin, and CI protein against CRCI is associated with the inhibition of AchE ( Pal et al, 2012 ; Kuzu et al, 2018 ; Wei et al, 2022 ). It is important to note that the contradictory results observed in these studies may be attributed to variations in the chemotherapy drugs and the specific method employed to determine AChE levels in different brain regions.…”

Section: Regulated Mechanism Of Natural Products In Crcimentioning

confidence: 99%

“…Studies have demonstrated that Galangin can inhibit the HMGB1/TLR4/NF-κB signaling pathway and decrease the production of TNF-α, IL-1β, and IL-6 (Abd El-Aal et al, 2022). Similarly, CI protein, Magnesium Isoglycyrrhizinate, Juglanin, Epicatechin, Morin, Caffeic acid phenethyl ester, Epigallocatechin Gallate, and Polydatin also alleviated neuroinflammation via blocking TLR4/NF-κB signaling (Mohamed et al, 2011;Kuzu et al, 2018;Jiang et al, 2019;Ali et al, 2020;Arafa and Atteia, 2020;Tong et al, 2020;Wei et al, 2022). Additionally, Resveratrol and Ginsenoside Rg1 inhibit inflammatory responses through inhibiting PPARγ/NF-κB signaling pathway (Shi et al, 2018;Shi et al, 2019).…”

Section: Hmgb1/tlr4/nf-κb Pathwaymentioning

confidence: 99%

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Natural products for the treatment of chemotherapy-related cognitive impairment and prospects of nose-to-brain drug delivery

He,

Zhou,

Jiang

et al. 2024

Front. Pharmacol.

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Chemotherapy-related cognitive deficits (CRCI) as one of the common adverse drug reactions during chemotherapy that manifest as memory, attention, and executive function impairments. However, there are still no effective pharmacological therapies for the treatment of CRCI. Natural compounds have always inspired drug development and numerous natural products have shown potential therapeutic effects on CRCI. Nevertheless, improving the brain targeting of natural compounds in the treatment of CRCI is still a problem to be overcome at present and in the future. Accumulated evidence shows that nose-to-brain drug delivery may be an excellent carrier for natural compounds. Therefore, we reviewed natural products with potential anti-CRCI, focusing on the signaling pathway of these drugs’ anti-CRCI effects, as well as the possibility and prospect of treating CRCI with natural compounds based on nose-to-brain drug delivery in the future. In conclusion, this review provides new insights to further explore natural products in the treatment of CRCI.

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Section: Natural Products For the Treatment Of Crcimentioning

confidence: 99%

Section: Natural Products For the Treatment Of Crcimentioning

confidence: 99%

Section: Regulated Mechanism Of Natural Products In Crcimentioning

confidence: 99%

Section: Hmgb1/tlr4/nf-κb Pathwaymentioning

confidence: 99%

See 2 more Smart Citations

Natural products for the treatment of chemotherapy-related cognitive impairment and prospects of nose-to-brain drug delivery

He,

Zhou,

Jiang

et al. 2024

Front. Pharmacol.

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“…Juglanin is a flavonoid glycoside isolated from the Chinese herb He Shou Wu. It has been found to possess anti-inflammatory, anticancer effects, and antioxidant ( 76 , 100 , 101 ). In the bleomycin-induced lung fibrosis model, Juglanin treatment significantly downregulated fibrosis markers, such as matrix metalloproteinase 9, TGF-β1, fibronectin, α-smooth muscle actin (α-SMA), and collagen type I.…”

Section: Targeting Cgas-sting Signaling Alleviates Pulmonary Fibrosismentioning

confidence: 99%

The role of cGAS-STING signaling in pulmonary fibrosis and its therapeutic potential

Zhang,

Chen

et al. 2023

Front. Immunol.

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Pulmonary fibrosis is a progressive and ultimately fatal lung disease, exhibiting the excessive production of extracellular matrix and aberrant activation of fibroblast. While Pirfenidone and Nintedanib are FDA-approved drugs that can slow down the progression of pulmonary fibrosis, they are unable to reverse the disease. Therefore, there is an urgent demand to develop more efficient therapeutic approaches for pulmonary fibrosis. The intracellular DNA sensor called cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS) plays a crucial role in detecting DNA and generating cGAMP, a second messenger. Subsequently, cGAMP triggers the activation of stimulator of interferon genes (STING), initiating a signaling cascade that leads to the stimulation of type I interferons and other signaling molecules involved in immune responses. Recent studies have highlighted the involvement of aberrant activation of cGAS-STING contributes to fibrotic lung diseases. This review aims to provide a comprehensive summary of the current knowledge regarding the role of cGAS-STING pathway in pulmonary fibrosis. Moreover, we discuss the potential therapeutic implications of targeting the cGAS-STING pathway, including the utilization of inhibitors of cGAS and STING.

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Juglanin ameliorates depression-like behavior in chronic unpredictable mild stress-induced mice by improving AMPK signaling

Ren

et al. 2022

Journal of Functional Foods

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Protective effect of Juglanin against doxorubicin-induced cognitive impairment in rats: Effect on oxidative, inflammatory and apoptotic machineries

Cited by 8 publications

References 41 publications

Natural products for the treatment of chemotherapy-related cognitive impairment and prospects of nose-to-brain drug delivery

Natural products for the treatment of chemotherapy-related cognitive impairment and prospects of nose-to-brain drug delivery

The role of cGAS-STING signaling in pulmonary fibrosis and its therapeutic potential

Juglanin ameliorates depression-like behavior in chronic unpredictable mild stress-induced mice by improving AMPK signaling

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