Juglanin ameliorates depression-like behavior in chronic unpredictable mild stress-induced mice by improving AMPK signaling

Ren, Yanrong; Hu, Shiwen; Pu, Hongzheng; Zhou, Ying; Jiang, Mingzhu; Li, Yuanyuan; Deng, Chaofang; Gao, Jie; Xu, Minxuan; Ge, Chenxu

doi:10.1016/j.jff.2022.105263

Cited by 3 publications

(1 citation statement)

References 54 publications

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“…Conversely, decreased responsiveness of AMPK activation during aging leads to various physiological changes that accelerate aging, such as reduced autophagy, heightened inflammation and fat deposition, hyperglycemia, deregulation (2024) 11:698 | https://doi.org/10.1038/s41597-024-03538-z www.nature.com/scientificdata www.nature.com/scientificdata/ of nutrient sensing and enhanced metabolic syndrome 12,49 . Interestingly, inactivation of the AMPK signaling pathway has also been associated with depressive-like behaviors, which can be ameliorated through pharmacological interventions promoting AMPK signaling activation 51,52 . Moreover, there is considerable evidence connecting the development of depression with aging through the deregulation of nutrient sensing via the AMPK signaling pathway 12 .…”

Section: Identification Of Longevity-associate Genes In Major Depress...mentioning

confidence: 99%

Molecular signatures of premature aging in Major Depression and Substance Use Disorders

Onisiforou,

Zanos,

Georgiou

2024

Sci Data

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Major depressive disorder (MDD) and substance-use disorders (SUDs) often lead to premature aging, increasing vulnerability to cognitive decline and other forms of dementia. This study utilized advanced systems bioinformatics to identify aging “signatures” in MDD and SUDs and evaluated the potential for known lifespan-extending drugs to target and reverse these signatures. The results suggest that inhibiting the transcriptional activation of FOS gene family members holds promise in mitigating premature aging in MDD and SUDs. Conversely, antidepressant drugs activating the PI3K/Akt/mTOR pathway, a common mechanism in rapid-acting antidepressants, may accelerate aging in MDD patients, making them unsuitable for those with comorbid aging-related conditions like dementia and Alzheimer’s disease. Additionally, this innovative approach identifies potential anti-aging interventions for MDD patients, such as Deferoxamine, Resveratrol, Estradiol valerate, and natural compounds like zinc acetate, genistein, and ascorbic acid, regardless of comorbid anxiety disorders. These findings illuminate the premature aging effects of MDD and SUDs and offer insights into treatment strategies for patients with comorbid aging-related conditions, including dementia and Alzheimer’s disease.

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Section: Identification Of Longevity-associate Genes In Major Depress...mentioning

confidence: 99%

Molecular signatures of premature aging in Major Depression and Substance Use Disorders

Onisiforou,

Zanos,

Georgiou

2024

Sci Data

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Inflammation as a shared mechanism of chronic stress related disorders with potential novel therapeutic targets

Gupta,

Agarwal

2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Potential Herbal Remedies for Treatment of Depression: A Mini Review

Yadav,

Rani,

Dua

2024

NPJ

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Background: Depression is a psychiatric and mood disorder that impacts a person's mental health and behavior and is frequently linked to suicide. As per the World Health Organization's estimate, depressive disorder will be the main cause of mental disorders by the year 2030, and it has a huge impact on the burden of disease in the world. To treat depression, there are pharmacological and nonpharmacological therapy alternatives. With little to no consideration of other neurochemicals altered in depression, most antidepressant preparations are based on the monoamines, neuroendocrine, and neuro-inflammation concepts. Objective: The present study aims to provide comprehensive data related to depression, the factors associated, the mechanism involved, herbal plants effective for managing depression, and novel formulations along with patents and clinical trials. Methods: A thorough assessment of herbs and novel formulations that have been proven effective in treating depression was conducted. After extensive review, the present study includes a mechanism of action of herbal plants showing antidepressant effects, novel formulations, patents, and clinical trials related to depression. Results: Numerous studies reported that diverse herbal plants have been found to have a positive effect on depression management, such as Panax ginseng, Melissa officinalis, Piper methysticum, Schinus molle L, Kielmeyera coriacea Mart, Elaeocarpus ganitrus, Hypericum perforatum, Lavandula angustifolia Mill, Crocus Sativus L. Conclusion: Herbal plant research could help establish the potential of isolated compounds from plants with medicinal properties for managing depressive illnesses.

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Juglanin ameliorates depression-like behavior in chronic unpredictable mild stress-induced mice by improving AMPK signaling

Cited by 3 publications

References 54 publications

Molecular signatures of premature aging in Major Depression and Substance Use Disorders

Molecular signatures of premature aging in Major Depression and Substance Use Disorders

Inflammation as a shared mechanism of chronic stress related disorders with potential novel therapeutic targets

Potential Herbal Remedies for Treatment of Depression: A Mini Review

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