Molecular signatures of premature aging in Major Depression and Substance Use Disorders
Anna Onisiforou,
Panos Zanos,
Polymnia Georgiou
Abstract:Major depressive disorder (MDD) and substance-use disorders (SUDs) often lead to premature aging, increasing vulnerability to cognitive decline and other forms of dementia. This study utilized advanced systems bioinformatics to identify aging “signatures” in MDD and SUDs and evaluated the potential for known lifespan-extending drugs to target and reverse these signatures. The results suggest that inhibiting the transcriptional activation of FOS gene family members holds promise in mitigating premature aging in… Show more
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