Protective effect of <i>Zanthoxylum armatum</i> fruit on Heart Mitochondrial Antioxidants Against Isoproterenol Induced Cardiac Damage in Rats

Mangalanathan, Malathi; Uthamaramasamy, Saraswathi; Venkateswaran, Ramalingam

doi:10.5958/0974-360x.2018.00128.2

Cited by 3 publications

(1 citation statement)

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“…The Mean±SD AST value of group-1,2,3 and 4 was 72.06 ± 5.623, 169. 26 Analysis of renal function tests (RFT) showed higher values when compared with control. The mean±SD values of blood urea (mg/dl) in group-1,2, 3 and 4 were 20.76 ± 2.965; 39.98 ± 4.977, 66.040 ± 5.038 and 89.88 ± 1.532 respectively.…”

Section: Changes In Biochemical Parametersmentioning

confidence: 98%

Untitled

2023

IJPSR

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Parkinson's disease has been a challenging neurodegenerative disorder for researchers and clinicians alike for decades. Though L-dopa has changed the management of PD to a considerable extent, effective solutions remain elusive since L-dopa, after a few years, partly loses its efficacy and develops dyskinesias as a complication, incapacitating the patient. Also, existing PD animal models using MPTP, rotenone, paraquet, etc cause significant suffering to the animals and also require a minimum of 22-25 days for induction. Hence, a better PD animal model was conceived considering the synergistic oxidative stress lipids, and rotenone induce on striatal neurons. The experiment compared the existing rotenone induction with combined rotenone and high-fat diet induction, carefully watching for motor and behavioural symptoms of PD in the Wistar rats in addition to measuring the biochemical profiles for toxicity, strictly following the ARRIVE guidelines for animal research. This study found that using HFD+Rot for induction not only shortened the duration of induction to a mean of 14 days but also reduced the suffering by reducing the number of intraperitoneal injections needed without significant derangement of safety biochemical parameters. This study also proves the effectiveness by demonstrating the reduced dopamine, serotonin levels in striatal neurons and increased oxidative stress parameters. To the best of our knowledge, no animal study shows a better PD model with all the neurobehavioural and biochemical features of PD with less time for induction. This new HFD+Rot model can therefore be employed to test therapeutics and neurobehavioural studies.

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Section: Changes In Biochemical Parametersmentioning

confidence: 98%

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2023

IJPSR

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To Evaluate the Cardioprotective effect of Hydroalcoholic Extract of Matricaria chamomilla Linn in Isoproterenol Induced Myocardial Infarction in Wistar Rats

Malviya¹,

Arya²,

Burange³

et al. 2022

RJPT

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The mаin оbjeсtive behind this examination wаs tо оbserve thаt if сhаmоmile is сараble оf hindering рlаsmа СK-MB асtivity, аmeliоrаted ISО-induсed myосаrdiаl dаmаge. The flоwer extrасt оf Сhаmоmile wаs extrасted with the helр оf ethаnоl аnd wаter in the rаtiо оf 70:30 by utilizing sоxhlet арраrаtus. Heаlthy аnimаls were utilized аnd were given the dоse оf 100-200mg/kg with isорrоterenоl. The outcomes reveаled thаt there wаs signifiсаnt ST-fragment elevаtiоn in isорrоterenоl-treаted rаts, however рre-treаtment with сhаmоmile extrасt mаrkedly restrаined isорrоterenоl-induсed ST-portion elevаtiоn interesting оf its сell membrаne рrоteсting effeсts. Myосаrdium соntаins аn аbundаnt аmоunt оf diаgnоstiс mаrker compounds fоr MI аnd оnсe metаbоliсаlly dаmаged, it releаses its intrасellulаr соntents intо the EСF. Henсe, the serum levels оf thоse mаrker chemicals refleсt the аlterаtiоns in membrаne honesty аnd/оr рermeаbility. Рre-treаtment with сhаmоmile extrасt (100 аnd 200mg/kg, resрeсtively) signifiсаntly lоwered the isорrоterenоl-induсed elevаtiоn оf serum levels оf these diаgnоstiс mаrker proteins. Оrаl аdministrаtiоn оf сhаmоmile extrасt signifiсаntly reduсes the асtivity оf СK аnd LDH in heаrt аnd аlsо аmeliоrаtes the оxidаtive pressure, accordingly reduсing саrdiо tоxiсity. In ISО аdministered rаts, the асtivity оf heаrt tissue аntiоxidаnt proteins wаs fоund tо be deсreаsed when соmраred tо соntrоl rаts. The рreliminаry histораthоlоgiсаl discoveries оf the isорrоterenоl induсed myосаrdium shоwed lаrge infrасted zоne with оedemа, соаgulаtive neсrоsis аnd inflаmmаtоry сells аnd seраrаtiоn оf саrdiас musсle strands. It саn be соnсluded thаt сhаmоmile extrасt соnsiderаbly imрrоved сellulаr аntiоxidаtive defenсe аgаinst оxidаtive pressure; it may wоrk аs а рreventive аntiоxidаnt by sсаvenging suрerоxide аniоns, оr а сhаin breаking аntiоxidаnt by sсаvenging liрid free rаdiсаls.

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Pharmacodynamic interaction of Terminalia arjuna (Roxb) with Ocimum sanctum (Linn) in Isoproterenol induced cardiac necrosis

Savant¹,

Kulkarni²,

Habbu

et al. 2022

AJPR

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Herbal drugs are used widely even when their biologically active compounds are unknown, probably because of their effectiveness, lesser side effects and affordability. In the present study we investigated the potential cardio-protective effect of combination of standardized extracts of Terminalia arjuna and Ocimum sanctum in isoproterenol induced myocardial infarction. Myocardial infarction was induced in rats by subcutaneous injection of Isoproterenol for two consecutive days at an interval of 24h. Rats were pre-treated with test drugs for the period of 21 days and Isoproterenol was administered on 20 and 21st day. At the end of experiment i.e on 22nd day hemodynamic, biochemical and histopathological study of heart tissue were evaluated from control and experimental groups. Isoproterenol treated animals showed significant increase in heart rate and cardiac biomarkers. Whereas, mean arterial blood pressure and antioxidant parameters were significantly decreased. Animals administered with different combinations of standardized extracts of Terminalia arjuna and Ocimum sanctum significantly maintained the levels of cardiac biomarkers, antioxidant parameters, mean arterial pressure and heart rate. Histopathology study showed marked myocardial necrosis in Isoproterenol treated animals and significant cardiac protection of animals treated with extract combinations. Hence, we may conclude that herb-herb combinations were found to be effective in prevention of myocardial injury induced by isoproterenol.

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Protective effect of Zanthoxylum armatum fruit on Heart Mitochondrial Antioxidants Against Isoproterenol Induced Cardiac Damage in Rats

Cited by 3 publications

References 0 publications

Untitled

Untitled

To Evaluate the Cardioprotective effect of Hydroalcoholic Extract of Matricaria chamomilla Linn in Isoproterenol Induced Myocardial Infarction in Wistar Rats

Pharmacodynamic interaction of Terminalia arjuna (Roxb) with Ocimum sanctum (Linn) in Isoproterenol induced cardiac necrosis

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