Protective effect ofTerminalia muelleriagainst carbon tetrachloride-induced hepato and nephro-toxicity in mice and characterization of its bioactive constituents

Abstract

Results: TMEF is rich in ellagitannins, galloyl esters, phenolic acids, and flavone-C-glucosides. TMEF pretreatment significantly (p50.001) inhibited the CCl 4 -induced increase in ALT (17, 43, and 53%), AST (20, 46, and 58%), ALP (20, 48, and 56%), LDH (21, 47, and 58%), hepatic MDA (23, 49, and 54%), renal MDA (22, 35, and 52%), creatinine (48, 66, and 91%), uric acid (16, 34, and 59%), urea (22, 39, and 59%), and cholesterol (20, 27, and 46%). Furthermore, TMEF administration significantly (p50.001) increased hepatic GSH (15, 51, and 79%), renal GSH (23, 45, and 73%), hepatic SOD (9, 52, and 95%), renal SOD (39, 66, and 85%) and protein levels (17, 24, and 29%) at the tested doses of TMEF, respectively. Pretreatment with TMEF preserved the hepatic architecture and protected from ballooning degeneration, liver necrosis, renal inflammation, and degeneration of the kidney tubules. Conclusion: TMEF has a marked hepato-nephro protective effect.

Hepatoprotective effects of blue honeysuckle on CCl4‐induced acute liver damaged mice

“…Acute liver damage was induced by single IP injection of CCl 4 (Sigma-Aldrich, St Louis, MO, USA), dissolved in olive oil (Sigma-Aldrich, St Louis, MO, USA) 1:19 (v/v) (5%) in a volume of 10 ml/kg (equivalent to 0.5 ml/kg of CCl 4 ), at 1 h after the seventh administration of the test material in accordance with previously established methods (Al-Sayed, Abdel-Daim, Kilany, Karonen, & Sinkkonen, 2015;Al-Sayed et al, 2014;Fahmy, Al-Sayed, Abdel-Daim, Karonen, & Singab, 2016;Ferreira et al, 2010;Wang et al, 2013). Instead of CCl 4 , equal volumes of olive oils were administered to the intact control mice; further, distilled water was orally administered 1 h after the seventh administration.…”

Nephroprotective effect of Berberis baluchistanica against gentamicin-induced nephrotoxicity in rabbit

“…More interest has developed to the protective effects of medicinal plants against chemically induced toxicities (Frei and Higdon, 2003). For example, Azima tetracantha (Konda et al, 2016) and Capparis spinosa (Tlili et al, 2017), Cestrum nocturnum (Saleem et al, 2017), Morus alba (Ullah et al, 2016), Nigella sativa (Begum et al, 2006), Sechium edule (Mumtaz et al, 2012), Terminalia muelleri (Fahmy et al, 2016) show nephroprotective effect.…”

Anti‐Inflammatory and Analgesic Activities of Terminalia Muelleri Benth. (Combretaceae)

“…Many pharmacological activities including antioxidant [Pfundstein et al, ], hepatoprotective [Eesha et al, ], antihyperlipidemic, antidiabetic [Latha and Daisy, ], anti‐inflammatory [Nair et al, ] and cytotoxic activities [Ponou et al, ] have been reported for different Terminalia species. The plants of the genus Terminalia are rich sources of various secondary metabolites, including triterpenes, flavonoids, and tannins [Pfundstein et al, ; Fahmy et al, ]. Terminalia muelleri Benth.…”