Protective effect of <i>S</i>‐allyl cysteine sulphoxide (alliin) on glycoproteins and hematology in isoproterenol induced myocardial infarction in male Wistar rats

Sangeetha, T.; Quine, S. Darlin

doi:10.1002/jat.1330

Cited by 18 publications

(15 citation statements)

References 35 publications

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“…Leaf extract obtained from plants grown under in situ condition was found to be effective in reducing serum glucose levels than ex situ grown plant. This is probably due to higher production of bioactive compounds, S-allyl cysteine sulfoxide, allicin, di( 2-propenyl) disulfide, or 2-propenyl propyl disulfide, though leaf extract was more effective as compared with glibenclamide (Sangeetha & Quine, 2008). The mechanism of hypoglycemic action probably involves direct or indirect stimulation of insulin secretion (Eidi et al, 2005;Nasim et al, 2009a).…”

Section: Resultsmentioning

confidence: 99%

Alliin obtained from leaf extract of garlic grown underin situconditions possess higher therapeutic potency as analyzed in alloxan-induced diabetic rats

Nasim

Dhir

Kapoor

et al. 2011

Pharmaceutical Biology

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Section: Resultsmentioning

confidence: 99%

Alliin obtained from leaf extract of garlic grown underin situconditions possess higher therapeutic potency as analyzed in alloxan-induced diabetic rats

Nasim

Dhir

Kapoor

et al. 2011

Pharmaceutical Biology

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“…The influence of isoproterenol administration on the levels of hemoglobin is underreported in the literature. Sangeetha & Quine [18] observed an increase in erythrocyte count and hemoglobin concentrations in rats undergone isoproterenol-induced myocardial infarction.…”

Section: Discussionmentioning

confidence: 99%

“…High counts of leukocytes and neutrophils were observed in rats with isoproterenol-induced myocardial infarction [18] and are considered at risk for the development of AMI [19]. Friedman et al [20] were the first to observe the relationship between neutrophil count and the subsequent development of AMI.…”

Section: Discussionmentioning

confidence: 99%

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Modelo experimental de infarto do miocárdio induzido por isoproterenol em ratos

Filho¹,

Ferreira²,

Sousa³

et al. 2011

Rev Bras Cir Cardiovasc

100

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Objective: To evaluate and validate, in our laboratory, the essay of myocardial infarction induced by isoproterenol in rats by means of analysis of hematological, biochemical, oxidative stress markers and histopathological parameters.Methods: Thirty young, male, Wistar rats (145 to 230 g) were randomly allocated in two groups: Sham group, which underwent a virtual myocardial infarction induction, and the Infarction group, which underwent a myocardial infarction induction with isoproterenol. The administrations for the infarction induction were performed during two consecutive days and a 24-hour interval between them. Twenty-four hours after the last administration, rats from both groups were anesthetized and sacrificed for blood sample collection to evaluate complete blood count (CBC) and biochemical parameters (SGOT, SGPT, troponin I, urea and creatinin), obtain myocardial fragments for oxidative stress markers analyses (catalase activity and glutathione concentrations) as well as histopathological examinations.Results: There were no death cases in the Sham group, while the mortality rate in the Infarction group was 25%. Myocardial infarction induction with isoproterenol raised leukocytes and neutrophils counts, SGOT, troponin I and urea concentrations, reduced catalase enzyme activity and glutathione concentrations in the myocardium and let to histopathological concentrations as well. It did not exert alterations in terms of hemoglobin, SGPT and creatinin concentrations.Conclusion: The isoproterenol-induced myocardial infarction essay in rats was adequately reproduced in our laboratory, causing alterations in hematological, biochemical, oxidative stress markers and histopathological parameters. Rev Bras Cir Cardiovasc 2011;26(3):469-76 In the literature, there is a series of studies using this model, evaluating the effect of different substances on biochemical, oxidative stress markers and histopathological damage resulting from myocardial in rats [8,9]. DescriptorsThis study aims to evaluate and validate, in our environment, the model of isoproterenol inducedmyocardial infarction in rats, given the scarcity of scientific publications using this model in our country METHODS This study, whose data are from a Master

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“…L-NNA was given orally (25 mg/kg/day) in drinking water to rats during 14 days to produce hypertension. To induce myocardial infarction, ISO was given intraperitoneally to rats (150 mg/kg/day) once a day for 2 consecutive days (20). Control group: untreated, LNNA group: rats were treated with L-NNA (25 mg/kg/day), LNNA+ISOgroup: L-NNA treated rats were given ISO (150 mg/kg) for 2 consecutive days in the 12 th and 13 th days of L-NNA treatment, LNNA+ISO+CAPE group: L-NNA treated rats were also given CAPE (10 μmol/kg/day) during 7 days after the first week and treated with ISO (150 mg/kg) for 2 consecutive days at the 12 th -13 th days of L-NNA treatment.…”

Section: Experimental Protocolsmentioning

confidence: 99%

The effect of caffeic acid phenethyl ester on isoproterenol-induced myocardial injury in hypertensive rats

İlhan¹,

Yılmaz²,

Nacar³

et al. 2014

Anadolu Kardiyol Derg

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Objective: The aim of this study is to investigate the effects of caffeic acid phenethyl ester (CAPE) on isoproterenol (ISO)-induced myocardial injury in hypertensive rats. Methods: Rats were divided into 4 groups (n=29):n=7) and L-NNA+ISO+CAPE (L-NNA+ISO + caffeic acid phenethyl ester) group (n=6). ISO (150 mg/kg/day) was given intraperitoneally (i.p.) once a day for 2 consecutive days (at the 12 th and 13 th days of L-NNA treatment). NG-Nitro-L-arginine (L-NNA) was given orally (25 mg/kg/ day) in drinking water for 14 days. CAPE (10 μmol/kg/day) was given (i.p.) for 7 days after the first week. Systolic blood pressure (SBP) was evaluated by the tail-cuff method and biochemical analysis were performed using an autoanalyzer and a spectrophotometer. Results: SBP in all L-NNA-treated groups was found to be increased at seventh day. AST and LDH levels in LNNA+ISO group were significantly increased compared to control (AST: 125±5 vs. 105±2; LDH: 861±154 vs. 571±46 U/L respectively) (p<0.05). Also, ISO caused to extensive necrosis and mononuclear cell infiltration in hypertensive rat myocardium. CAPE application reversed the enhanced AST and LDH levels as well as the extensive necrosis and the mononuclear cell infiltration in LNNA+ISO+CAPE group compared LNNA+ISO. Conclusion: According to our findings, it might be suggested that CAPE may be a favorable agent to protect the hypertensive myocardium from the injury induced by isoproterenol via mechanisms such as the induction of the antioxidant enzymes and the inhibition of lipid peroxidation.

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Protective effect of S‐allyl cysteine sulphoxide (alliin) on glycoproteins and hematology in isoproterenol induced myocardial infarction in male Wistar rats

Cited by 18 publications

References 35 publications

Alliin obtained from leaf extract of garlic grown underin situconditions possess higher therapeutic potency as analyzed in alloxan-induced diabetic rats

Alliin obtained from leaf extract of garlic grown underin situconditions possess higher therapeutic potency as analyzed in alloxan-induced diabetic rats

Modelo experimental de infarto do miocárdio induzido por isoproterenol em ratos

The effect of caffeic acid phenethyl ester on isoproterenol-induced myocardial injury in hypertensive rats

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