Protective effect of<i>angelica sinensis</i>polysaccharide on experimental immunological colon injury in rats

Liu, Shaoping; Dong, Weiguo; Wu, Dongfang; Luo, Hao; Yu, Jie-Ping

doi:10.3748/wjg.v9.i12.2786

Cited by 52 publications

(33 citation statements)

References 37 publications

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“…They also found an increase of SOD levels in treatment groups compared to colitis model group. Liu et al (2003) obtained similar results according to SOD levels in TNBS plus ethanol induced experimental colitis as well. On the other hand, SOD levels decreased by the effect of AA were shown to be increased in our study following NAC treatment in accordance with the studies mentioned above.…”

Section: Discussionsupporting

confidence: 70%

“…Toxic colitic injury has been shown to increase MDA levels in rats and on the contrary various agents used in the treatment of the disease were shown to decrease it (Paiva et al 2002;Liu et al 2003;Mahgoub et al 2003). In addition, NAC was also shown to decrease the levels of MDA in studies in which experimental damage was formed other than colitis (Aydin et al 2002;Ozaras et al 2003;Park et al 2003).…”

Section: Discussionmentioning

confidence: 99%

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Beneficial Effects of N-Acetylcysteine on Acetic Acid-Induced Colitis in Rats

Çetinkaya¹,

Bülbüloğlu²,

Kurutaş³

et al. 2005

Tohoku J. Exp. Med.

103

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Ulcerative colitis is a chronic recurrent inflammatory bowel disease in which oxidative stress has been implicated. The aim of the present study was to evaluate possible protective effects of N-acetylcysteine against acetic acid-induced colitis in a rat model. Rats were administered intrarectal saline (control group) or acetic acid (colitis model group). Rats with acetic acid-induced colitis were treated by intraperitoneal or intrarectal administration of N-acetylcysteine (500 mg/ kg) (treated group). Another series of rats were pre-treated by intraperitoneal or intrarectal administration of N-acetylcysteine, then administered intrarectal acetic acid (pre-treated group). The degree of tissue injuries was assessed by macroscopical and histopathological scores of the colonic mucosa. Malondialdehyde, myeloperoxidase, reduced glutathione, superoxide dismutase, and catalase levels were measured in tissue extracts of the dissected colon. Administration of N-acetylcysteine intraperitoneally or intrarectally ameliorated macroscopic score alterations produced by acetic acid in treated groups. In addition, microscopical improvement was observed in all N-acetylcysteine-treated rats compared to untreated animals with colitis. In the colonic tissues of the acetic acid-induced colitis, myeloperoxidase activity and malondialdehyde levels were elevated, while the reduced glutathione levels and superoxide dismutase and catalase activities were decreased. However, intraperitoneal or intrarectal treatment with N-acetylcysteine reversed these parameters, compared to the untreated colitis group. Notably, intrarectal administration of N-acetylcysteine elevated the reduced glutathione levels more markedly compared to the other treatment groups. Superoxide dismutase levels were increased in intraperitoneally or intrarectally N-acetylcysteine-treated groups significantly compared to the control, colitis and pre-treated groups. But there was no significant increase in catalase activity. In conclusion, N-acetylcysteine could be beneficial as a complementary agent in treatment of ulcerative colitis.N-acetylcysteine; colitis; reactive oxygen species; acetic acid; GSH

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Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Beneficial Effects of N-Acetylcysteine on Acetic Acid-Induced Colitis in Rats

Çetinkaya¹,

Bülbüloğlu²,

Kurutaş³

et al. 2005

Tohoku J. Exp. Med.

103

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show abstract

“…For example, activity of CAT has been reported to be unchanged after acetic acid-induced colitis [44]. Regarding SOD, the existing reports support increased level of SOD in acetic acid model of colitis [44][45][46] and also in TNBS plus ethanolinduced colitis [47]. Decreased or increased activities of SOD and CAT both indicate an imbalance between oxidants and antioxidants within the tissue.…”

Section: Discussionmentioning

confidence: 91%

Molecular evidences on the benefit of N-acetylcysteine in experimental colitis

et al. 2008

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“…In addition, genetic, immunological factors and oxidative stress factors are involved [2,3]. Several experimental IBD in vivo studies have showed increased antioxidant enzymes to metabolize the oxidative toxic intermediates [4,5]. Currently, there is no curative treatment and conventional pharmacological drugs had partial efficacy, being unable to maintain a long-term clinical remission [4,6,7].…”

Section: Introductionmentioning

confidence: 99%