Protective effect of Hesperidin and Tiger nut against Acrylamide toxicity in female rats

Hamdy, Soha M.; Shabaan, Amany M.; Latif, Abdel Karim M. Abdel; Abdel-Aziz, Ayman M.; Amin, Alshimaa M.

doi:10.1016/j.etp.2017.05.004

Cited by 35 publications

(19 citation statements)

References 37 publications

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“…We observed elevated levels of AST, ALT, and ALP. The evidence of hepatic damage and levels of serum enzymes (e.g., AST, ALT, and ALP) were reported by other authors [ [20] , [21] , [22] , [32] , [33] , [34] , [35] ].…”

Section: Discussionsupporting

confidence: 70%

Alterations of blood chemistry, hepatic and renal function, and blood cytometry in acrylamide-treated rats

Rivadeneyra-Domínguez

Becerra-Contreras

Vázquez-Luna

et al. 2018

Toxicology Reports

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Acrylamide is a vinyl monomer that is widely used for the synthesis of polyacrylamides, the treatment of drinking water, and as an additive in cosmetics. Acrylamide is also produced during the thermal processing of carbohydrate-rich foods. Although the potential toxic effects of acrylamide have been reported, few studies have evaluated biochemical parameters in blood. The present study investigated alterations of blood chemistry, hepatic function, and blood cytometry in acrylamide-treated rats. Thirty-two male Wistar rats were assigned to four experimental groups (n = 8/group): one control group received 0.3 ml of vehicle (saline solution), and the other three groups received acrylamide (25, 50, and 75 mg/kg, i.p., for 14 days). At the end of treatment, blood samples were collected to obtain serum, which was then processed using a Vitros250 device. For blood cytometry, the samples were processed in a Sysmex analyzer. The blood chemistry results showed that urea nitrogen, urea, and creatinine were elevated in the acrylamide-treated groups. Tests of hepatic function showed that total and direct bilirubins, transaminases, and alkaline phosphatase were also elevated compared with vehicle, whereas the levels of total proteins and albumin decreased. Blood cytometry showed that the levels of erythrocytes, hemoglobin, hematocrit, leukocytes, and platelets and mean cell volume decreased in the acrylamide-treated groups compared with vehicle. Overall, the present findings indicate that acrylamide causes deleterious effects on renal and hepatic physiology, producing dose-dependent alterations of blood chemistry and cytometry parameters in male Wistar rats.

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Section: Discussionsupporting

confidence: 70%

Alterations of blood chemistry, hepatic and renal function, and blood cytometry in acrylamide-treated rats

Rivadeneyra-Domínguez

Becerra-Contreras

Vázquez-Luna

et al. 2018

Toxicology Reports

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“…Moreover, the antioxidant activity of tiger nut polyphenols was investigated in comparison with flavonoids from a chemoprotective perspective. A dietary supplementation with 25% of whole tiger nut showed moderate renal and hepatoprotective properties against acrylamide-induced toxicity in rats [47].…”

Section: Nutritional Characteristics and Bioactive Compounds Of Tigermentioning

confidence: 95%

Nutritional and Microbiological Quality of Tiger Nut Tubers (Cyperus esculentus), Derived Plant-Based and Lactic Fermented Beverages

et al. 2018

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Tiger nut (Cyperus esculentus) is a tuber that can be consumed raw or processed into beverages. Its nutritional composition shows a high content of lipid and dietary fiber, close to those of nuts, and a high content of starch, like in other tubers. Tiger nuts also contain high levels of phosphorus, calcium, and phenolic compounds, which contribute to their antioxidant activity. From those characteristics, tiger nuts and derived beverages are particularly relevant to limit food insecurity in regions where the plant can grow. In Europe and United States, the tiger nut derived beverages are of high interest as alternatives to milk and for gluten-free diets. Fermentation or addition of probiotic cultures to tiger nut beverages has proven the ability of lactic acid bacteria to acidify the beverages. Preliminary sensory assays concluded that acceptable products are obtained. In the absence of pasteurization, the safety of tiger nut-based beverages is not warranted. In spite of fermentation, some foodborne pathogens or mycotoxigenic fungi have been observed in fermented beverages. Further studies are required to select a tailored bacterial cocktail which would effectively dominate endogenous flora, preserve bioactive compounds and result in a well-accepted beverage.

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“…The dosage of ACR and TAU in this study was used according to previous studies. 21,22 Rats were intoxicated with ACR (50 mg/kg/day purchased from Genview, Naples, Florida, USA) or saline vehicle by intraperitoneal injection. On completion of 2 weeks of ACR administration, rats were treated with TAU (200 mg/kg/day; Sigma, St Louis, Missouri, USA) using drinking water as vehicle.…”

Section: Methodsmentioning

confidence: 99%

Taurine attenuates acrylamide-induced apoptosis via a PI3K/AKT-dependent manner

Sun

Wang

et al. 2018

Hum Exp Toxicol

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As a potent neurotoxic agent, acrylamide (ACR) is formed in food processing at higher temperature. Taurine (TAU), a nonessential amino acid, is used to cure neurodegenerative disorders, followed by activation of the phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) signaling pathway. In this article, we certified that antiapoptotic efficacy of TAU in vivo and vitro. ACR-treated rats received TAU by drinking water 2 weeks after ACR intoxication. The results showed that in treated rats, TAU alleviated ACR-induced neuronal apoptosis, which was associated with the activation of PI3K/AKT signaling pathway. TAU attenuated apoptosis caused by ACR through observing terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL)-positive cells, measure of protein expression of Bcl-2, Bax, and caspase 3 activity. TAU-induced antiapoptotic effect is PI3K/AKT-dependent, which was proved in ACR-intoxicated ventral spinal cord 4.1 cells in the presence of AKT inhibitor, MK-2206. Therefore, our results demonstrated that TAU-attenuated ACR-induced apoptosis in vivo through a PI3K/AKT-dependent manner provided new sights in the molecular mechanism of TAU protection against ACR-induced neurotoxicity.

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Protective effect of Hesperidin and Tiger nut against Acrylamide toxicity in female rats

Cited by 35 publications

References 37 publications

Alterations of blood chemistry, hepatic and renal function, and blood cytometry in acrylamide-treated rats

Alterations of blood chemistry, hepatic and renal function, and blood cytometry in acrylamide-treated rats

Nutritional and Microbiological Quality of Tiger Nut Tubers (Cyperus esculentus), Derived Plant-Based and Lactic Fermented Beverages

Taurine attenuates acrylamide-induced apoptosis via a PI3K/AKT-dependent manner

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