Protective Effect of Ginger (&lt;b&gt;&lt;i&gt;Zingiber officinale&lt;/i&gt;&lt;/b&gt; Roscoe) Extract against Oxidative Stress and Mitochondrial Apoptosis Induced by Interleukin-1β in Cultured Chondrocytes

Hosseinzadeh, Azam; Juybari, Kobra Bahrampour; Fatemi, Mohammad Javad; Kamarul, Tunku; Bagheri, Aboulfazl; Tekiyehmaroof, Neda; Sharifi, Ali Mohammad

doi:10.1159/000479789

Cited by 68 publications

(38 citation statements)

References 46 publications

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“…In a study by Hosseinzadeh and co-workers (2017), the toxicity of ginger on chondrocytes was investigated, and no cytotoxicity was observed even at high concentrations of ginger extract in chondrocyte cells [69]. In addition, they reported that ginger extract could significantly reduce IL-1β-induced oxidative stress, mitochondrial changes, and apoptosis [69].…”

Section: Gingermentioning

confidence: 99%

Herbal Remedies as Potential in Cartilage Tissue Engineering: An Overview of New Therapeutic Approaches and Strategies

et al. 2020

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It is estimated that by 2023, approximately 20% of the population of Western Europe and North America will suffer from a degenerative joint disease commonly known as osteoarthritis (OA). During the development of OA, pro-inflammatory cytokines are one of the major causes that drive the production of inflammatory mediators and thus of matrix-degrading enzymes. OA is a challenging disease for doctors due to the limitation of the joint cartilage’s capacity to repair itself. Though new treatment approaches, in particular with mesenchymal stem cells (MSCs) that integrate the tissue engineering (TE) of cartilage tissue, are promising, they are not only expensive but more often do not lead to the regeneration of joint cartilage. Therefore, there is an increasing need for novel, safe, and more effective alternatives to promote cartilage joint regeneration and TE. Indeed, naturally occurring phytochemical compounds (herbal remedies) have a great anti-inflammatory, anti-oxidant, and anabolic potential, and they have received much attention for the development of new therapeutic strategies for the treatment of inflammatory diseases, including the prevention of age-related OA and cartilage TE. This paper summarizes recent research on herbal remedies and their chondroinductive and chondroprotective effects on cartilage and progenitor cells, and it also emphasizes the possibilities that exist in this research area, especially with regard to the nutritional support of cartilage regeneration and TE, which may not benefit from non-steroidal anti-inflammatory drugs (NSAIDs).

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Section: Gingermentioning

confidence: 99%

Herbal Remedies as Potential in Cartilage Tissue Engineering: An Overview of New Therapeutic Approaches and Strategies

et al. 2020

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“…Zingiber officinale is a rhizome commonly consumed as a delicacy, medicine or spice [10] Ginger is a strong antioxidant substance and may either mitigate or prevent generation of free radicals. It has been reported for antioxidants and protective role against toxicants, insecticidal, antimicrobial and antiprotozoal activities [11][12][13][14]. It has also been recently been reported to improve growth performances in experimental animals [15].…”

Section: Introductionmentioning

confidence: 99%

In-vitro antioxidants, antimicrobial and toxicological evaluation of Nigerian Zingiber officinale

et al. 2018

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Background: Zingiber officinale is a rhizome commonly consumed as a delicacy, medicine or spice. It is considered as a safe spice with several medicinal properties. The aim of this study was to evaluate in-vitro antioxidants, antimicrobial and safety of Nigerian Z. Officinale. Methods: Methanol extract of Nigerian Z. Officinale (MEZO) was evaluated for phytochemical composition, total flavonoids and phenol contents using standard procedures. Antibacterial study was carried out via the agar well diffusion method. Antioxidant activities were carried out using 2, 2′-diphenyl-1-picrylhydrazyl (DPPH), and ferric reducing antioxidant properties (FRAP) assay. Twenty five (25) wister rats were randomly grouped into five (A-E) of five animals each. Animals in Groups AD were orally administered 75,150, 300 and 600 mg/kg bwt of the extract on daily basis for 4 weeks while those in Group A (control) received distilled water. Results: Total phenolic and flavonoids contents of the extract were 15.24 ± 0.02 mg GAE/g and 19.84 ± 0. 32 mg/g CE respectively. The extract promoted an inhibition of free radicals with IC 50 values of 47.05 ± 2. 03 μg/mL and 89.15 ± 0.29 μg/mL in DPPH and FRAP assay. At extract concentration of 100 μg/mL, K. pneumoniae showed the highest susceptibility of 29.04 ± 0.35 mm, followed by P. aeuruginisa (26.03 ± 0.41 mm), while S. aureus (15.08 ± 0.20 mm) was least susceptible. The serum concentrations of alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), sodium, albumin, total proteins and the computed organs/body weight ratios compared favorably (p > 0.05) with control at all extract doses tested. The bilirubin, urea and creatinine levels significantly (p < 0.05) increase while chloride decreases in rats dosed 600 mg/kg bwt. However, potassium level increases significantly (p < 0.05) in rats dose 300 mg/kg of the extract when compare with the control. Conclusion: This study revealed the strong antioxidant and antimicrobial potentials of methanol extract of Nigerian Zingiber officinale. It was also found to be relatively safe for consumption and thus could serve as a source of candidate for the development of new antioxidants and antimicrobial drugs.

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“…It is characterized by the presence of essential oil and a mixture of pungent tasting phenolic compounds (gingerols, gingerdiols, gingerdiones, dihydrogingerdiones, and shogaols) [7]. In a recent in vitro study, it has been shown that ginger extract was able to attenuate oxidative stress and reduce succeeding cell death of chondrocytes resulting from a mitochondrial apoptosis [56]. Ginger preparations also inhibited LPS-induced PGE 2 formation in U937 cells and decreased levels of TNF-α and IL-1β in murine peritoneal macrophages [57].…”

Section: Herbal Medicinal Products For Oral Use In the Treatment Of Omentioning

confidence: 99%

Herbal Medicinal Products in the Treatment of Osteoarthritis

Maksimović¹,

Samardžić²

2019

Osteoarthritis Biomarkers and Treatments

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Osteoarthritis (OA) is the most common form of arthritis, which represents a substantial economic burden for society and significantly affects patients' quality of life. Current conventional treatments of OA may be insufficiently effective and unsafe. In an attempt to overcome these limitations, many patients use herbal medicinal products (HMPs) and dietary supplements. A considerable number of herbal drugs and preparations (e.g., willow bark, Salicis cortex; devil's claw root, Harpagophyti radix; blackcurrant leaf, Ribis nigri folium; nettle leaf/herb, Urticae folium/herba; meadowsweet/meadowsweet flower, Filipendulae ulmariae herba/flos; rosemary leaf/oil, Rosmarini folium/aetheroleum; and juniper oil, Juniperi aetheroleum) are traditionally employed to relieve minor articular pain. Active constituents (e.g., sesquiterpene lactones, triterpenic acids, diarylheptanoids, iridoid glycosides, phenolic glycosides, procyanidins, and alkaloids) are not often fully known. Experimental studies suggest that herbal extracts/compounds are able to suppress inflammation, inhibit catabolic processes, and stimulate anabolic processes relevant to OA. Therapeutic benefit of most HMPs is expected solely from the experience of their long-standing traditional use. Efficacy and safety of several HMPs were assessed in clinical trials. The growing body of preclinical and clinical evidence provides rationale for the use of herbal products in the treatment of OA. However, at present, they cannot be recommended to patients with confidence.

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Protective Effect of Ginger (<b><i>Zingiber officinale</i></b> Roscoe) Extract against Oxidative Stress and Mitochondrial Apoptosis Induced by Interleukin-1β in Cultured Chondrocytes

Cited by 68 publications

References 46 publications

Herbal Remedies as Potential in Cartilage Tissue Engineering: An Overview of New Therapeutic Approaches and Strategies

Herbal Remedies as Potential in Cartilage Tissue Engineering: An Overview of New Therapeutic Approaches and Strategies

In-vitro antioxidants, antimicrobial and toxicological evaluation of Nigerian Zingiber officinale

Herbal Medicinal Products in the Treatment of Osteoarthritis

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