Protective effect of gallic acid against bleomycin-induced pulmonary fibrosis in rats

Abstract

Results of the present study demonstrate that GA, by its antioxidant properties, attenuates oxidative damage and fibrosis induced by BLM. Thus, an effective supplement with GA as an adjuvant therapy may be a very promising compound in reducing the side effects of BLM.

Saffron Protection against Bleomycin-Induced Pulmonary Fibrosis in Rats

“…According to Figure 2B, myeloperoxidase level contributing neutrophil activity in fibrosis phenomenon was markedly decreased by saffron treatment [28]. Inflammatory cytokines including TNF-α, IL-1β, and IL-6 are increased following bleomycin treatment [29]. In the same manner, in our study, TNF-α as a proinflammatory cytokine was increased in bleomycin-treated group compared to control (34.23±9.2 ng/ml versus 12.43±6.4ng/ml) while saffron treatment clearly prevented this event ( Figure 3).…”

Inhibitory Effect of Edible Additives on Collagenase Activity and Softening of Chilled Grass Carp Fillets

“…; Nikbakht et al . ). There were no significant differences amongst the total collagen contents in fillets treated with tea polyphenol, Na‐citrate or the control group, suggesting tea polyphenol and Na‐citrate may not slow down the degradation of collagen in fillets during ice or superchilling storage.…”

“…Madhan et al (2001) also indicated that the gallic acid complex was involved in the stabilization of collagen. Catechin and gallic acid have been used in biomedical fields to inhibit the degradation of collagen or to increase its synthesis (Madhan et al 2007;Nikbakht et al 2015). There were no significant differences amongst the total collagen contents in fillets treated with tea polyphenol, Na-citrate or the control group, suggesting tea polyphenol and Na-citrate may not slow down the degradation of collagen in fillets during ice or superchilling storage.…”

Traditional Chinese medicine for pulmonary fibrosis therapy: Progress and future prospects

“…The results showed that oral administration of GA significantly reversed the increase of inflammatory or fibrotic changes, collagen content, levels of MDA, and pro-inflammatory cytokines such as TNF-α and IL-1β, and the decrease of non-enzymatic (total thiol) and enzymatic (GPx) antioxidant contents in the rats' lung tissue induced by BLM. Thus, the supplement with GA as an adjuvant therapy in fibrotic lung disease may be a promising compound in reducing the side effects of BLM (Nikbakht et al, 2015). Therefore, further data in vivo and in clinical are indispensable to confirm its role in this area.…”

“…Preclinical studies have shown that GA possesses different pharmacological effects including anti-oxidant, antiapoptotic (Sohi et al, 2003). In a PF model, the rats were given GA orally at doses (50, 100, and 200 mg/kg/day) for 28 consecutive days started 7 days before the administration of single intratracheal instillation of BLM (Nikbakht et al, 2015). The results showed that oral administration of GA significantly reversed the increase of inflammatory or fibrotic changes, collagen content, levels of MDA, and pro-inflammatory cytokines such as TNF-α and IL-1β, and the decrease of non-enzymatic (total thiol) and enzymatic (GPx) antioxidant contents in the rats' lung tissue induced by BLM.…”