2017
DOI: 10.29252/arakmu.11.6.7
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Abstract: Background: Bleomycin-induced lung fibrosis has been accepted as an animal model for fibrosis in

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Cited by 2 publications
(3 citation statements)
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“…The ameliorative effects of saffron on bleomycininduced fibrosis in murine models were confirmed in our previous experiment [11]. Contrary to methylprednisolone, the measure of the body weight had no change with oral saffron treatment during our study compared to control (Fig.…”
Section: Discussionsupporting
confidence: 87%
See 1 more Smart Citation
“…The ameliorative effects of saffron on bleomycininduced fibrosis in murine models were confirmed in our previous experiment [11]. Contrary to methylprednisolone, the measure of the body weight had no change with oral saffron treatment during our study compared to control (Fig.…”
Section: Discussionsupporting
confidence: 87%
“…The animals in MP group were treated with 2.5 mg/kg of methylprednisolone intraperitoneally for 16 d while normal saline solution was injected into the other groups with the same schedule. Rats in group S were treated with 100mg/kg saffron solution orally (once daily) while the other groups received water alone [9][10][11]. At the end of our study (28 days following bleomycin injection), the animals were anesthetized and sacrificed.…”
Section: Experimental Protocolmentioning
confidence: 99%
“… 45 In line with this, saffron potently decreased the level of Malondialdehyde (MDA) and inflammatory cytokines in bleomycin-induced pulmonary fibrosis. 46 Similarly, crocin significantly reduced the over-expression of fibrotic molecules such as collagen 1a, α-smooth muscle actin (α-SMA), and TGF-β in hepatic fibrosis condition. 47 …”
Section: Introductionmentioning
confidence: 98%