Protective effect of gallic acid and gallic acid-loaded Eudragit-RS 100 nanoparticles on cisplatin-induced mitochondrial dysfunction and inflammation in rat kidney

Dehghani, Mohammad Amin; Maram, Nader Shakiba; Moghimipour, Eskandar; Khorsandi, Layasadat; khah, Morteza Atefi; Mahdavinia, Masoud

doi:10.1016/j.bbadis.2020.165911

Cited by 50 publications

(30 citation statements)

References 46 publications

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“…According to the different metal prosthetic groups, SOD can be roughly divided into three categories, namely Cu/ZnSOD, MnSOD (also known as SOD2), and FeSOD. Cu/Zn-SOD mainly exists in the cytoplasm while SOD2 is widely presented in the mitochondria (Dehghani et al, 2020), and the reduction of its expression and activity will weaken the scavenging effect of superoxide ions (a form of ROS) produced in the mitochondria, leading to peroxidative damage of mitochondrial DNA. In addition, GSH-Px is an important peroxidase that exists widely in the body.…”

Section: Discussionmentioning

confidence: 99%

A Novel Antioxidant Protects Against Contrast Medium-Induced Acute Kidney Injury in Rats

et al. 2020

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Many studies proposed that oxidative stress and apoptosis are key mechanisms in the pathogenesis of contrast-induced acute kidney injury (CI-AKI). Xylose-pyrogallol conjugate (XP) is an original effective antioxidant that showed decent antioxidant and anti-apoptosis effect before. Thus the therapeutic effect and mechanism of XP in preventing CI-AKI in the short and long term were investigated in this research. Renal function and histological grade were evaluated to determine the severity of renal injury. Kidney samples were then collected for the measurement of oxidative stress markers and the detection of apoptosis. Transmission electron microscopy (TEM) and western blot of mitochondrial protein were utilized for the analysis of the mitochondrial conditions. The results demonstrated that the CI-AKI rats caused a significant decrease in renal function accompanied by a remarkable increase in Malondialdehyde (MDA), bax, caspase-3, cytochrome c (Cyt C) level, TdT-mediated dUTP nick end labeling (TUNEL) positive apoptotic cells, and damaged mitochondria, while a decline in antioxidase activities and mitochondrial superoxide dismutase 2 (SOD2) expression compared with the control rats. However, when XP (50 or 100 or 200 mg/kg/day) was given orally for consecutive 7 days before CI-AKI modeling, XP (200 mg/kg) showed a better capability to restore renal dysfunction, histopathological appearance, the level of apoptosis, mitochondrial damage, oxidative stress, and fibrosis generation without interference in computed tomographic imaging. Our study indicated that antioxidant XP played a nephroprotective role probably via antiapoptotic and antioxidant mechanisms. Besides, XP may regulate the mitochondria pathway via decreasing the ratio of bax/bcl-2, inhibiting caspase-3 expression, cytochrome c release, and superoxide dismutase 2 activity. Overall, XP as a high-efficient antioxidant may have the potentials to prevent CI-AKI.

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Section: Discussionmentioning

confidence: 99%

A Novel Antioxidant Protects Against Contrast Medium-Induced Acute Kidney Injury in Rats

et al. 2020

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“…Previous studies have shown that GA can protect the reproductive system of rats incumbent on manganese and AFB1‐induced oxidative and inflammatory damage (Owumi et al., 2020). It has been also reported that GA exhibits curative effects on CP‐induced nephrotoxicity and bone marrow genotoxicity (Akomolafe et al., 2014; Dehghani et al., 2020; Shruthi et al., 2018).…”

Section: Introductionmentioning

confidence: 99%

“…Also, its anti-in ammatory effect prevents or reduces the expression of in ammatory molecules and thus can be used in the treatment of in ammatory diseases (Kim et al 2006). Previous studies have reported that GA exhibits curative effects on CP-induced nephrotoxicity and bone marrow genotoxicity (Akomolafe et al 2014;Shruthi et al 2018;Dehghani et al 2020) It is very important to protect male reproductive health against CP toxicity in chemotherapy. However, no adequate study has been found on the effects of GA on cisplatin-induced testis and epidiymis toxicity.…”

Section: Introductionmentioning

confidence: 99%

“…Gallic acid (GA), a polyphenol compound found in many vegetables and fruits such as bananas, strawberries, sumac, green tea and oak bark, exhibits antioxidant, anti‐inflammatory, anticancer and antiviral effects (Zhu et al., 2019). GA that is widely used in medicine, cosmetics and foods attracts the attention of researchers because of its useful effects (Dehghani et al., 2020). The antioxidant effect of GA ensures that the functions of biological systems are carried out properly, and the balance between the oxidant and antioxidant mechanism is maintained (Shruthi et al., 2018).…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of protective effects of gallic acid on cisplatin‐induced testicular and epididymal damage

Altındağ

Meydan

2021

Andrologia

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The current study explored the bene cial effects of GA against testis and epididymis toxicity induced by CP treatment. Male rats were into 4 groups (n=7). Control (saline, intraperitoneal), Cisplatin (a single dose of 8 mg/kg/day cisplatin, intraperitoneal), Gallic acid (50 mg/kg Gallic acid orally for 10 days) and Cisplatin+Gallic acid groups. Total number of spermatogonia, Sertoli, Leydig cell and the total volume of testis, seminiferous tubule, interstitial area, and germinal epithelial thickness and numerical densities of caspase-3, Bax, Bcl-2, 8-OHdG immunopositive cells were calculated. Histopathological examination of the testis and epididymis was performed. MDA and CAT levels are measured in the testis. Also, the testosterone level was measured in the serum of the rats. As a result, a signi cant decrease was observed in all stereological data, Bcl-2 immunopositive cell number, CAT, and serum testosterone levels in the testis compared to the CP group control group, while a signi cant increase was observed in the number of caspase-3, Bax, and 8-OHdG immunopositive cells and the level of MDA. However, GA signi cantly improved these parameters. Our study reveals that GA may improve CP-induced male reproductive toxicity by reducing oxidative stress, suppressing apoptosis and DNA damage, and restoring structural and functional deterioration.

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“…[70][71][72] Other studies have shown that nano-gallic acid is more bioavailable than pure gallic acid and can therefore more effectively alleviate oxidative stress, inflammatory response and mitochondrial dysfunction. 73 The study of nano-gallic acid may become a future research direction.…”

Section: Antioxidant Effects Of Phenolic Acidsmentioning

confidence: 99%

Current State of Knowledge on the Antioxidant Effects and Mechanisms of Action of Polyphenolic Compounds

Long

Gong

et al. 2021

Natural Product Communications

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Quality-of-life improvements have resulted in increasing attention being paid to research on antiaging and antioxidation. Polyphenols are natural antioxidants with excellent biological activities, such as antioxidation and scavenging of free radicals and antiviral activity. Abundant availability and low toxicity of polyphenols have attracted the attention of researchers. In this paper, the antioxidant activities of flavonoids, phenolic acids, stilbenes and lignan polyphenols are analyzed, the corresponding antioxidant mechanisms are investigated, and the antioxidant effects of polyphenols are systematically reviewed. Thus, an effective reference based on the recent literature is compiled for the study of the antioxidant mechanisms of polyphenols that provides a significant theoretical basis for the development of products that are components of polyphenols.

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Protective effect of gallic acid and gallic acid-loaded Eudragit-RS 100 nanoparticles on cisplatin-induced mitochondrial dysfunction and inflammation in rat kidney

Cited by 50 publications

References 46 publications

A Novel Antioxidant Protects Against Contrast Medium-Induced Acute Kidney Injury in Rats

A Novel Antioxidant Protects Against Contrast Medium-Induced Acute Kidney Injury in Rats

Evaluation of protective effects of gallic acid on cisplatin‐induced testicular and epididymal damage

Current State of Knowledge on the Antioxidant Effects and Mechanisms of Action of Polyphenolic Compounds

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