Protective effect of food derived nutrients on cisplatin nephrotoxicity and its mechanism

Abstract

Platinum-based metal complexes especially cisplatin (cis-diamminedichloroplatinum II, CDDP) possesses strong anticancer properties and a broad anticancer spectrum. However, the clinical application of CDDP has been limited by its side effects...

Acer truncatum Bunge seed oil ameliorated oxaliplatin-induced demyelination by improving mitochondrial dysfunction via the Pink1/Parkin mitophagy pathway

“…Recent studies have shown that Pink1/Parkin-mediated mitophagy prevented oxaliplatin-induced kidney injury and cognitive impairment. [19][20][21] However, whether Pink1/Parkin-mediated mitochondrial autophagy can be activated to prevent oxaliplatin-induced demyelination needs to be further demonstrated. Therefore, the hypothesis of this study is that remyelination by ATSO is related to the improvement of mitochondrial function by the Pink1/Parkin mitophagy pathway.…”