Protective effect of erdosteine metabolite I against hydrogen peroxide-induced oxidative DNA-damage in lung epithelial cells

Marabini, Laura; Calò, Rossella; Braga, Pier Carlo

doi:10.1055/s-0031-1300590

Cited by 13 publications

(10 citation statements)

References 24 publications

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“…The results corroborate the findings of Marabini et al that erdosteine exert anti-inflammatory and anti-oxidant properties due to the presence of a pharmacologically active sulfhydryl group that has been found to have a free radical scavenging activity. 43 The histopathological results of this study indicated that the irradiated group revealed atrophied glomeruli. Widened Bowman's space and thickened basement membrane were seen.…”

Section: Discussionmentioning

confidence: 54%

Protective effects of erdosteine against nephrotoxicity caused by gamma radiation in male albino rats

El-Kady

Ibrahim

2015

Hum Exp Toxicol

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The aim of this study was focused on investigating the possible protective effect of erdosteine against gamma radiation-induced renal lesions in male albino rats. Twenty-eight albino rats were divided into four equal groups as follows: control group, irradiated group (animals subjected to whole-body gamma irradiation at a dose of 5 Gy), treated group (each rat received 100 mg/kg body weight once daily, orally by gastric tube, erdosteine for 1 week), and treated irradiated group (each rat received 100 mg/kg body weight once daily, orally by gastric tube, erdosteine for 1 week, then exposed to whole-body gamma irradiation at a dose of 5 Gy). The results revealed that the administration of erdosteine to rats before irradiation significantly ameliorated the changes occurred in kidney function (creatinine and urea) compared with irradiated group. Also the changes in serum tumor necrosis factor α, interleukin 1β, and interleukin 6 activities were markedly improved compared with the corresponding values of irradiated group. Kidney catalase and glutathione peroxidase (GPx) activities and reduced glutathione concentration showed approximately normal level when compared with the irradiated group. The histopathological results showed distinctive pattern of renal lesions in irradiated group, while in treated irradiated group the renal tissues showed relatively well-preserved architecture. Erdosteine acts in the kidney as a potent scavenger of free radicals to prevent or ameliorate the toxic effects of gamma irradiation as shown in the biochemical and histopathological changes and might provide substantial protection against radiation-induced inflammatory damage.

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Section: Discussionmentioning

confidence: 54%

Protective effects of erdosteine against nephrotoxicity caused by gamma radiation in male albino rats

El-Kady

Ibrahim

2015

Hum Exp Toxicol

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“…Because of these characteristics, ER's activity in many diseases has been the subject of research (18)(19)(20). Erden et al studied the effectiveness of ER's in a pulmonary fi brosis model, using bleomycin in rats, and demonstrated that it prevents neutrophil accumulation with inhibition by inhibiting acute lung injury and fi brosis, lipid peroxidation and chemokine production (6).…”

Section: Discussionmentioning

confidence: 99%

Attenuation of bleomycin induced lung fibrosis by erdosteine and inhibition of the inducible nitric oxide synthase

Kayhan¹,

Tütüncü²,

Güzel³

et al. 2015

BLL

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Background and objectives: Despite advances in treatment modalities, the discovery of optimal medical therapies still remains a necessity in the management of pulmonary fi brosis. Material and methods:The experiments were performed in 35 adult Sprague Dawley rats, randomly allotted into one of fi ve groups (n=7). The control group was treated with 1 ml/kg, 0.9 % saline; the BLM group was given a single dose of BLM (2.5 U/kg); the BLM+ER group was treated with ER (10 mg/kg/day po) for 14 days after BLM administration; the BLM+SMT group was treated with i.p injections of SMT (20 mg/kg/ day) for 14 days after BLM administration; the BLM+ER+SMT group was treated with ER and SMT for 14 days after BLM administration. At the end of day 14, the results of histopathological, biochemical, and immunohistochemical investigations were analyzed. Results: Serum TNF-α, nitrate/nitrite, and TBARS levels signifi cantly increased in BLM group compared to control group (p < 0.001, p < 0.001 and p < 0.05 respectively). Lung tissue content of IL-6 was found to be lower in BLM+ER, BLM+SMT and BLM+ER+SMT groups compared to BLM group by immunhistochemical examinations (p < 0.01, p < 0.01 and p < 0.001, respectively). Similarly, the TNF-α reactions (p < 0.01 for each group) and NF-kB expressions were shown to be signifi cantly different among the study groups (p < 0.05, p < 0.05 and p < 0.001, respectively). Conclusion: Based on our study, ER and SMT attenuate BLM-induced pulmonary fi brosis; the combination of two agents has a greater protective effi cacy against fi brosis than one alone, reducing the infl ammatory markers (Tab. 2, Fig. 2, Ref. 31). Text in PDF www.elis.sk.

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“…Cells are constantly exposed to reactive oxygen species including those metabolically generated as products of aerobic respiration [ 32 , 33 ] and those originated from environmental pollutants [ 34 ]. It has been observed that hydrogen peroxide concentrations above 100 μ M are cytotoxic and genotoxic in A549 cells [ 35 ] causing DNA damage [ 36 ] and inducing the catalytic activities of DNA topoisomerase complexes [ 37 – 39 ]. Furthermore, the H 2 O 2 -induced damage could be also revealed by the oxidation of DNA bases, for instance, guanine adducts like 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxo-dG) [ 40 ].…”

Section: H 2 O 2 Indmentioning

confidence: 99%

Molecular and Cellular Effects of Hydrogen Peroxide on Human Lung Cancer Cells: Potential Therapeutic Implications

Vilema-Enríquez

Arroyo

Grijalva

et al. 2016

Oxidative Medicine and Cellular Longevity

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Lung cancer has a very high mortality-to-incidence ratio, representing one of the main causes of cancer mortality worldwide. Therefore, new treatment strategies are urgently needed. Several diseases including lung cancer have been associated with the action of reactive oxygen species (ROS) from which hydrogen peroxide (H2O2) is one of the most studied. Despite the fact that H2O2 may have opposite effects on cell proliferation depending on the concentration and cell type, it triggers several antiproliferative responses. H2O2 produces both nuclear and mitochondrial DNA lesions, increases the expression of cell adhesion molecules, and increases p53 activity and other transcription factors orchestrating cancer cell death. In addition, H2O2 facilitates the endocytosis of oligonucleotides, affects membrane proteins, induces calcium release, and decreases cancer cell migration and invasion. Furthermore, the MAPK pathway and the expression of genes related to inflammation including interleukins, TNF-α, and NF-κB are also affected by H2O2. Herein, we will summarize the main effects of hydrogen peroxide on human lung cancer leading to suggesting it as a potential therapeutic tool to fight this disease. Because of the multimechanistic nature of this molecule, novel therapeutic approaches for lung cancer based on the use of H2O2 may help to decrease the mortality from this malignancy.

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Protective effect of erdosteine metabolite I against hydrogen peroxide-induced oxidative DNA-damage in lung epithelial cells

Cited by 13 publications

References 24 publications

Protective effects of erdosteine against nephrotoxicity caused by gamma radiation in male albino rats

Protective effects of erdosteine against nephrotoxicity caused by gamma radiation in male albino rats

Attenuation of bleomycin induced lung fibrosis by erdosteine and inhibition of the inducible nitric oxide synthase

Molecular and Cellular Effects of Hydrogen Peroxide on Human Lung Cancer Cells: Potential Therapeutic Implications

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