Protective effect of Echinacea purpurea (Immulant) against cisplatin-induced immunotoxicity in rats

Khalaf, Abdelazeem Ali; Hussein, Shaymaa; Tohamy, Adel F.; Marouf, Sherif; Yassa, Hanan Dawood; Zaki, Amr R.; Bishayee, Anupam

doi:10.1007/s40199-019-00265-4

Cited by 25 publications

(23 citation statements)

References 41 publications

(39 reference statements)

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“…Table 7. Mean background contents of trace elements in surface soils (Khalaf et al 12 ). www.nature.com/scientificreports/ Increasing the NO 3 − concentration leads to increase of release rate over time.…”

Section: Resultsmentioning

confidence: 99%

“…According to Saeed et al (2018), accumulation of phenolic compounds in the plant rhizomata cum radicibus prevents NO 3 − toxicity in plants. There are some reports showing that stress conditions increase either phenylalanine ammonia lyase (PAL) synthesis or activity in plants 6,11,12,14,32 ; other authors 24 have found that some stress treatments delay the increase in wound-induced PAL activity. Phenylalanine Ammonia-Lyase activity was found to vary greatly with the stage of plant development 18 .…”

Section: Discussionmentioning

confidence: 99%

“…Cation exchange capacity (CEC) was determined with 1 mol L −1 sodium acetate solution (pH 8.2) and 96% ethanol 14 . Calcium carbonate (CaCO 3 ) was measured after boiling of 2.5 g soil with 25 mL of 0.5 N hydrochloric acid (HCl) 12 . Three fractions (sand, silt, and clay) of soil particles were determined following the pipette method 15 .…”

Section: Materials and Methods Experimental Backgroundmentioning

confidence: 99%

“…The anti-radical scavenging activity of samples was evaluated based on the colorimetric method 12 . Briefly, 15 μL of methanolic extract was added to 2.0 mL of the 2, 2-diphenyl-1-picrylhydrazyl (DPPH) solution and the mixture was incubated in dark place at 20 °C for 30 min 12 . Then the absorbance was measured at 517 nm.…”

Section: Methodsmentioning

confidence: 99%

“…Decreasing of severity and symptoms of the common cold by using E. purpurea extracts was reported in several clinical studies 11 . According to immunological studies, E. purpurea enhanced activation of the nonspecific cellular and increased humoral immunity by increasing the activation and production of monocytes, lymphocytes, leukocytes and cytokines 12 . Based on the studies, the immune-stimulatory property is the most important property of the species that involves the immune system based on the dose level 13 .…”

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confidence: 99%

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Improving growth properties and phytochemical compounds of Echinacea purpurea (L.) medicinal plant using novel nitrogen slow release fertilizer under greenhouse conditions

Ahmadi

Samadi

Rahimi

2020

Sci Rep

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Medicinal plant production is most important than other agricultural plants due to their phytochemical compounds effects on human health. Paying attention to plant nutrition requirement is so important. In order to assess the effect of nitrate (NO 3 −) dosage supplies from two types of fertilizers on growth and phytochemical properties of Echinacea purpurea rhizomata cum radicibus, an experiment with completely simple design was carried out under greenhouse conditions. two types of fertilizers (new invented nitrogen (N) slow release fertilizer and urea chemical fertilizer) at three dosages (50, 100, and 150 mM) were applied. Plant growth parameters and total phenolic (TPC), total flavonoids (TFC), polysaccarides content, essential oil content, caffeic acid derivatives, and anti-radical scavenging activities of E. purpurea were assessed. The results showed the significant (p ≤ 0.01) differences among treatments, both in growth and phytochemical properties. Using of n slow release, especially in 150 mM dosage, significantly increased all the plant growth and phytochemical properties. The dried E. purpurea rhizomata cum radicibus contained more caftaric acid (max 12.56 mg g −1 DW) and chicoric acid (max 7.56 mg g −1 DW) than other derivatives. Despite the impact of heavy metals on yield and growth of E. purpurea, the concentration of all heavy metals and micronutrients (boron (B), cadmium (cd), copper (cu), iron (fe), manganese (Mn), molybdenum (Mo), nickel (ni), lead (pb), and zinc (Zn)) in studied soil and fertilizer samples was less than United States environmental protection Agency (USepA) limits of contamination. Based on the results, using of n slow release fertilizers can improve phytochemical properties of the plant due to its polymeric structure and can be a suitable substitution of chemical fertilizers, especially in medicinal plants growth. Many of researchers are pay attention to herbal and medicinal plants as natural remedies due to their bioactive compounds recently 1,2. Echinacea purpurea (L.) Moench is one of the most important medical plants of Asteraceae family with various pharmacological effects 3. The major three species of Echinacea are known as Echinacea angustifolia, Echinacea purpurea, and Echinacea pallida. E. purpurea is native to much of the United States and its morphological properties are also known as purple coneflower with orange and cone-shaped flowering head that change to purple, rose, or white petals during June to September 4. It has a narrow leaves and three feet height stem with dark, thick and pungent rhizomata cum radicibus 5. In the environment, E. purpurea grows randomically along water canals with low densities for affective harvest for commercial purposes 6. Comparing of other Echinacea species, E. purpurea is the most able species to adjust to new conditions. It is resistance to heat or cold weather conditions, easy to grow, and flaunt high efficiency 7,8. Numerous scientific

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Materials and Methods Experimental Backgroundmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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Improving growth properties and phytochemical compounds of Echinacea purpurea (L.) medicinal plant using novel nitrogen slow release fertilizer under greenhouse conditions

Ahmadi

Samadi

Rahimi

2020

Sci Rep

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A randomized, double‐blind, placebo‐controlled study on immune improvement effects of ethanolic extract of Echinacea purpurea (L.) Moench in Korean adults

Lee,

Kim

et al. 2024

Phytotherapy Research

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Echinacea purpurea (L.) Moench (EP), a medicinal plant native to North America, is now cultivated in various regions including Europe. With increasing popularity of Echinacea in Korea recently, a human clinical trial was conducted to evaluate immune‐enhancing efficacy and safety of EP 60% ethanolic extract (EPE) in Koreans. Eighty volunteers were recruited for this randomized, double‐blind, placebo‐controlled clinical trial. They were randomly divided into two groups and given either a daily dose of 200 mg of EPE or a placebo. All participants underwent testing for Natural Killer (NK) cell cytotoxic activity, serum cytokine levels (IL‐2, IL‐6, IL‐10, IL‐12, IFN‐γ, TNF‐α), Wisconsin Upper Respiratory Symptom Survey‐21 (WURSS‐21), and Multidimensional Fatigue Scale (MFS) during this study to assess changes in outcomes. After 8 weeks of EPE consumption, a significant increase in NK cell cytotoxic activity compared to the placebo was observed. Additionally, serum cytokine levels of IL‐2, IFN‐γ, and TNF‐α also significantly increased following EPE consumption. However, no significant changes were observed in WURSS‐21 and MFS before and after EPE consumption. Throughout the 8‐week study period, no adverse reactions were reported in relation to EPE consumption, and there were no clinically significant changes in diagnostic laboratory tests or vital signs in the EPE group. These results indicate that consumption of EPE could lead to immune improvement without any adverse effects. This clinical trial was the first to demonstrate beneficial effects of EPE consumption on immunity in Korean adults.

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Perlite particle size and NO3-/NH4+ ratio affect growth and chemical composition of purple coneflower (Echinacea purpurea L.) in hydroponics

Ahmadi

Samadi

Sepehr

et al. 2021

Industrial Crops and Products

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Protective effect of Echinacea purpurea (Immulant) against cisplatin-induced immunotoxicity in rats

Cited by 25 publications

References 41 publications

Improving growth properties and phytochemical compounds of Echinacea purpurea (L.) medicinal plant using novel nitrogen slow release fertilizer under greenhouse conditions

Improving growth properties and phytochemical compounds of Echinacea purpurea (L.) medicinal plant using novel nitrogen slow release fertilizer under greenhouse conditions

A randomized, double‐blind, placebo‐controlled study on immune improvement effects of ethanolic extract of Echinacea purpurea (L.) Moench in Korean adults

Perlite particle size and NO3-/NH4+ ratio affect growth and chemical composition of purple coneflower (Echinacea purpurea L.) in hydroponics

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