Protective effect of dietary ginger on antioxidant enzymes and oxidative damage in experimental diabetic rat tissues

Shanmugam, Kirubanandan; Korivi, Mallikarjuna; Nishanth, K.; Kuo, Chia‐Hua; Reddy, Kesireddy Sathyavelu

doi:10.1016/j.foodchem.2010.07.104

Cited by 93 publications

(88 citation statements)

References 32 publications

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“…Researchers observed in previous studies that diabetes increases lipid peroxidation in several organs and changes the activities of antioxidant enzymes (Shanmugam et al 2011;Suresh et al 2013). There are also studies about diabetes causes histological alterations in different tissues (Degirmenci et al 2005;Arnal et al 2010;Shanmugam et al 2011).…”

Section: Discussionmentioning

confidence: 99%

“…There are also studies about diabetes causes histological alterations in different tissues (Degirmenci et al 2005;Arnal et al 2010;Shanmugam et al 2011). In STZ-treated control rats the serum urea, uric acid, creatinine levels and kidney MDA contents, histopathological results significantly increased; kidney antioxidant enzyme activities significantly reduced.…”

Section: Discussionmentioning

confidence: 99%

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Lycopene Protects the Diabetic Rat Kidney Against Oxidative Stress-mediated Oxidative Damage Induced by Furan

Pandır

Ünal

Baş

2016

Braz. arch. biol. technol.

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Furan is a food and environmental contaminant and a potent carcinogen in animals. Lycopene is one dietary carotenoid found in fruits such as tomato, watermelon and grapefruit. The present study was designed to explore the protective effect of lycopene against furan-induced oxidative damage in streptozotocin (STZ)-induced diabetic rat kidney. At the end of the experimental period (28 days), we found that lycopene markedly decreased the malondialdehide (MDA) levels in the kidney, urea, uric acid and creatinine levels in the serum of furan-treated rats. The increase of histopathology in the kidney of furan-treated rats were effectively suppressed by lycopene. Furthermore, lycopene markedly restored superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione-S-transferase (GST) activities in the kidney of furan-treated rats.In conclusion, these results suggested that lycopene could protect the rat kidney against furan-induced injury by improving renal function, attenuating histopathologic changes, reducing MDA production and renewing the activities of antioxidant enzymes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Lycopene Protects the Diabetic Rat Kidney Against Oxidative Stress-mediated Oxidative Damage Induced by Furan

Pandır

Ünal

Baş

2016

Braz. arch. biol. technol.

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“…Supplementation with ω-3 fatty acids made no signifi cant change in catalase activity. The catalase activity of liver and kidney is reported to be decreased in most of the current literature on diabetic subjects (13,14). Glucose auto-oxidation, protein glycation, and interaction of advanced glycation end-products with their specifi c receptors on macrophages are the main mechanisms of increased production of oxygen free radicals in diabetes (15,16).…”

Section: Discussionmentioning

confidence: 99%

Effect of vitamins A, E, C and omega-3 fatty acids supplementation on the level of catalase and superoxide dismutase activities in streptozotocin-induced diabetic rats

Tabei¹,

Fakher²,

Djalali³

et al. 2015

BLL

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Abstract:Background: Since free radicals and antioxidant enzymes may play an important role in the development of diabetes, the present study was designed to assess the effect of supplementation with vitamins A, E and C and ω-3 fatty acids on catalase and superoxide dismutase activity in streptozotocin (STZ)-induced diabetic rats. Methods: A total of 64 male Wistar rats weighing 250 g were divided into four groups as normal control, diabetic control, diabetic supplemented with vitamin A, E and C and diabetic supplemented with ω-3 fatty acids. After four weeks the rats were anesthetized and catalase (CAT) and superoxide dismutase (SOD) activities were investigated in blood samples, liver and heart homogenates. Results: In diabetic rats, the activity levels of heart SOD (p < 0.001) and heart and liver CAT (p < 0.001) were signifi cantly lower than in normal control rats. Supplementation with vitamins A, E and C signifi cantly increased heart CAT (p = 0.05). No signifi cant change was observed in diabetic rats supplemented with ω-3 fatty acids. Conclusion: Supplementation with vitamins A, E and C and ω-3 fatty acids was found to increase heart CAT activity in diabetic rats and they can be valuable candidates in the treatment of the complications of diabetes (Tab. 6, Ref. 26). Text in PDF www.elis.sk.

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“…The biochemical enzymes, SOD, CAT and GPx, are the preventive antioxidants, while uric acid, vitamin C, GSH, albumin, vitamin E are the major chain breaking antioxidants [39,43,44]. Scientific studies have shown that ginger reduces the oxidative stress induced by various hepatotoxins by increasing the activity/levels of the antioxidant enzymes [8,45,46], and this mechanism would have played a cardinal role in the observed hepatoprotective effects of ginger against diverse class of toxicants.…”

Section: Ginger Enhances Antioxidant Defense Systems In Vivomentioning

confidence: 99%

Ginger Protects the Liver against the Toxic Effects of Xenobiotic Compounds: Preclinical Observations

Haniadka¹,

Saxena²,

Shivashankara³

et al. 2013

J Nutr Food Sci

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According to the World Health Organization, chronic liver disease is a major ailment and causes significant morbidity and mortality in both western and developing countries. However, till date no ideal hepatoprotective agents are available in the modern system of medicine to effective prevent and cure liver ailments. This has necessitated the need to depend on complementary and alternative systems of medicine for liver ailments and diseases. Zingiber officinale Roscoe commonly known as ginger is arguably one of the most commonly used spice, and is an integral part of our diet. In addition to its dietary use, ginger is also reported to possess myriad health benefits, and has been used in the various traditional and folk systems of medicine to treat various ailments and illnesses. Preclinical studies carried out in the past decade have shown that ginger possesses hepatoprotective effects, and to protect against diverse xenobiotic compounds like alcohol, acetaminophen, fungicides, tetracycline, heavy metals and organophosphorus compounds. Mechanistic studies have shown that the protective actions are mediated through free radical scavenging, antioxidant, cytoprotective, and to modulate the levels of the detoxifying enzymes. This review for the first time summarizes the results related to the beneficial properties of ginger in ameliorating the toxic effects of hepatotoxins, and also emphasizes the aspects that warrant future research to establish its activity and utility as a broad spectrum hepatoprotective agent.

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Protective effect of dietary ginger on antioxidant enzymes and oxidative damage in experimental diabetic rat tissues

Cited by 93 publications

References 32 publications

Lycopene Protects the Diabetic Rat Kidney Against Oxidative Stress-mediated Oxidative Damage Induced by Furan

Lycopene Protects the Diabetic Rat Kidney Against Oxidative Stress-mediated Oxidative Damage Induced by Furan

Effect of vitamins A, E, C and omega-3 fatty acids supplementation on the level of catalase and superoxide dismutase activities in streptozotocin-induced diabetic rats

Ginger Protects the Liver against the Toxic Effects of Xenobiotic Compounds: Preclinical Observations

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