Protective effect of dieckol isolated from Ecklonia cava against ethanol caused damage in vitro and in zebrafish model

Kang, Min‐Cheol; Kim, Kil-Nam; Kang, Sung-Myung; Yang, Xiudong; Kim, Eun-A.; Song, Choon Bok; Nah, Jae‐Woon; Jang, Mi-Kyeong; Lee, Jung-Suck; Jung, Won‐Kyo; Jeon, You‐Jin

doi:10.1016/j.etap.2013.09.018

Cited by 34 publications

(25 citation statements)

References 29 publications

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“…However, these results indicated that fucoxanthin can protect the HUVEC against high glucose induced oxidative stress. Recently, zebrafish models have been widely used and investigated for in vivo studies including cancer, melanoma, cardiovascular disease, immune system, antioxidative stress (Berman, Skariah, Maro, Mingnot, & Mourrain, 2009;Kang et al, 2013b;Lam, Chua, Gonq, Lam, & Sin, 2004;Li, Huang, Huang, Du, & Hung, 2012;Yang et al, 2012). Zebrafish has numerous advantages for experimental studies such as low cost, large clutches, and physiological similarity to mammals (Dooley & Zon, 2000).…”

Section: Discussionmentioning

confidence: 99%

Protective effect of fucoxanthin isolated from Ishige okamurae against high-glucose induced oxidative stress in human umbilical vein endothelial cells and zebrafish model

Kang

Lee

et al. 2014

Journal of Functional Foods

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Available online A B S T R A C THigh glucose induced oxidative stress is implicated in intracellular toxicity in tissue and blood vessel such as oxidative stress, lipid peroxidation, and cell death. In this study, we attempted to investigate protective effects of fucoxanthin isolated from Ishige okamurae against high glucose induced oxidative stress in human umbilical vein endothelial cells (HUVEC) and zebrafish model. The ROS generation, lipid peroxidation and cell death were significantly reduced in both the fucoxanthin treated HUVEC and zebrafish in vivo model, compared to those of both negative controls. This study indicates that fucoxanthin could protect cells and organ injury against oxidative stress induced by high glucose in vitro HUVEC and in vivo zebrafish model.

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Section: Discussionmentioning

confidence: 99%

Protective effect of fucoxanthin isolated from Ishige okamurae against high-glucose induced oxidative stress in human umbilical vein endothelial cells and zebrafish model

Kang

Lee

et al. 2014

Journal of Functional Foods

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“…Dieckol 5 was able to impair the oxidative stress effects induced by ethanol in zebrafish embryos [61]. A concentration of 20 µM decreased ROS formation by 80% and lipid peroxidation by 5%.…”

Section: Dieckolmentioning

confidence: 92%

“…A concentration of 20 µM decreased ROS formation by 80% and lipid peroxidation by 5%. The attenuation of oxidative stress led to a 15% decrease in ethanol-induced liver cell death, showing that dieckol possesses a hepatoprotective effect [61]. Dieckol at the same dose also decreased the oxidative effects caused by high glucose, by significantly reducing heart rate, ROS, lipid peroxidation, and cell death in zebrafish (Table 1) [60].…”

Section: Dieckolmentioning

confidence: 94%

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Seaweed Secondary Metabolites with Beneficial Health Effects: An Overview of Successes in In Vivo Studies and Clinical Trials

et al. 2019

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Macroalgae are increasingly viewed as a source of secondary metabolites with great potential for the development of new drugs. In this development, in vitro studies are only the first step in a long process, while in vivo studies and clinical trials are the most revealing stages of the true potential and limitations that a given metabolite may have as a new drug. This literature review aims to give a critical overview of the secondary metabolites that reveal the most interesting results in these two steps. Phlorotannins show great pharmaceutical potential in in vivo models and, among the several examples, the anti-dyslipidemia activity of dieckol must be highlighted because it was more effective than lovastatin in an in vivo model. The IRLIIVLMPILMA tridecapeptide that exhibits an in vivo level of activity similar to the hypotensive clinical drug captopril should still be stressed, as well as griffithsin which showed such stunning results over a variety of animal models and which will probably move onto clinical trials soon. Regarding clinical trials, studies with pure algal metabolites are scarce, limited to those carried out with kahalalide F and fucoxanthin. The majority of clinical trials currently aim to ascertain the effect of algae consumption, as extracts or fractions, on obesity and diabetes.Studies focusing on the preparation of macroalgae extracts and their chemical characterization revealed a large range of seaweed compounds with very interesting biological activities including antitumor, anti-inflammatory, antimicrobial, antidiabetic, antivirus, antihypertensive, fat-lowering, and neuroprotective activities [12][13][14][15].The large volume of studies proving the seaweed compound activities in in vitro systems [16][17][18][19] hints the need for further advancements in the knowledge about macroalgae compound efficiency in living systems (in vivo) and their use in the development of pharmaceuticals. In vitro studies are very relevant and yield very important information, but they only represent the first step of a long process, and the results obtained rarely reveal anything about the effects of a compound in vivo, because the responses observed in vitro can be magnified, diminished, or totally different in a more complex and integrated system. In fact, in vivo studies and clinical trials are those which contribute most to truly understanding the real potential of compounds as future pharmaceuticals.In this regard, the present work intends to present insight into the results obtained in the last few years regarding secondary metabolites, such as phlorotannins, halogenated compounds, fucoxanthin, and fucosterol isolated from macroalgae, involved in in vivo studies and clinical trials, identifying the research opportunities and knowledge gaps, to valorize these compounds and their natural resources. The intention is not to present an exhaustive survey of all published works, but rather a selection of authors based on the following criteria: in-depth studies involving pure compounds most characteristic f...

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“…Western blot analysis revealed reduced cell apoptosis through the activation of B cell lymphoma-extra large (Bcl-xL) and PARP and down-regulation of Bax and caspase-3, providing evidence for this potential protective agent against ethanol-induced liver diseases. In an in vivo study in a zebrafish model, the dieckol-treated group scavenged intracellular ROS and prevented lipid peroxidation and ethanol-induced cell death in embryos (Kang et al 2013c cytochrome c from mitochondria to the cytosol in a dosedependent manner (Lee et al 2012a). PG isolated from ES decreased the formation of lipid peroxide in acetaminophen (800 mg/kg, i.p.…”

Section: Hepatoprotective Activitymentioning

confidence: 99%

Recent advances in pharmacological research on Ecklonia species: a review

2017

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The genus Ecklonia (Lessoniaceae, Phaeophyceae), commonly called kelp (brown algae), is abundant on the coasts of Japan and Korea. During the past few decades, Ecklonia species have received tremendous attention for their wide range of therapeutic properties and multiple health benefits, such as great nutritional value and being rich in vitamins, minerals, dietary fiber, proteins, and polysaccharides. Several novel functional ingredients with diversified biological activities have been isolated and possess antimicrobial, antiviral, hepatoprotective, cardioprotective, anti-inflammatory, neuroprotective, anticarcinogenic, immunomodulatory, hypolipidemic, anti-diabetic, and antioxidant therapeutic properties. The present review discusses the phytochemical, pharmacological, therapeutic, nutritional, and health benefits of different species of genus Ecklonia, as well as their use in the prevention of disease and maintenance of good health.

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Protective effect of dieckol isolated from Ecklonia cava against ethanol caused damage in vitro and in zebrafish model

Cited by 34 publications

References 29 publications

Protective effect of fucoxanthin isolated from Ishige okamurae against high-glucose induced oxidative stress in human umbilical vein endothelial cells and zebrafish model

Protective effect of fucoxanthin isolated from Ishige okamurae against high-glucose induced oxidative stress in human umbilical vein endothelial cells and zebrafish model

Seaweed Secondary Metabolites with Beneficial Health Effects: An Overview of Successes in In Vivo Studies and Clinical Trials

Recent advances in pharmacological research on Ecklonia species: a review

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