Protective effect of dapsone against bleomycin-induced lung fibrosis in rat

Investigation of the histopathological level of Ki-67, caspase-3 expressions of the effects of hesperidin on wound healing in the rat esophagus

“…GSH is among the important components of intracellular protective mechanisms against a variety of harmful stimuli, including oxidative stress. MPO activity is an enzyme that explains the presence of neutrophils 30 , 31 . Gupta et al showed that after skin injury, levels of MDA were highly increased while level of GSH peroxidase was decreased when compared to control group 32 .…”

Antifibrotic effect of AD-1 on lipopolysaccharide-mediated fibroblast injury in L929 cells and bleomycin-induced pulmonary fibrosis in mice

“…48 Subsequently, this can cause lipid peroxidation, and the resulting malondialdehyde (MDA) impairs the antioxidant defense of cells, thus resulting in cell harm. 49 At the same time, the body will counteract oxidative stress injury by activating the enzymatic antioxidant system with superoxide dismutase (SOD) as the main component and the non-enzymatic antioxidant system with glutathione (GSH) as the main component. 50 SOD and GSH are significant indicators of oxidative stress, and an increase in their expression indicates an increase in the body's antioxidant capacity, which is helpful in delaying the progression of PF.…”

Treatment mechanism of immune triad from the repurposing drug against COVID-19

“…Inflammatory factors and oxidative stress cause IPF. Bleomycin also induces IPF in an in vivo model, but dapsone decreases the total number of inflammatory cells in bleomycin-induced IPF, such as neutrophils and eosinophils [ 87 ]. Dapsone treats neuroinflammasome diseases such as mild cognitive impairment, exacerbated Alzheimer's conditions, and Stroke [ 52 , 88 , 89 ].…”