Protective effect of Danhong Injection combined with Naoxintong Capsule on cerebral ischemia-reperfusion injury in rats

Wan, Jiayang; Wan, Haofang; Yang, Rongbin; Wan, Haitong; Yang, Jiehong; Zhou, Huifen

doi:10.1016/j.jep.2017.10.002

Cited by 38 publications

(25 citation statements)

References 38 publications

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“…This conclusion is consistent with Chen Gang's report. This fully verifies the success in model establishment [5] . Cell apoptosis is one kind of "programmed cell death".…”

Section: Discussionsupporting

confidence: 67%

Cerebral protection Effect of Danhong Injection on CPB Rats

2018

2018 7th International Conference on Medical Engineering and Biotechnology (MEDEB 2018)

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Objective: to observe the influence of Danhong injection on cerebral infarction area and neuron apoptosis rate of rats undergoing cardiopulmonary bypass (CPB) and then discuss cerebral protection effect of Danhong injection. Method: 24 healthy and adult SD rats were divided into sham operation group, CPB group and medicine intervention group at random. Each group includes 8 rats. Cerebral infarction area and neuron apoptosis rate of 3 groups were compared. Results: compared with CPB group, cerebral infarction area of medicine intervention group decreased (P＜0.05). Compared with sham operation group, OD value of apoptotic cells in CPB group rose significantly (P＜0.01). Compared with CPB group, OD value of apoptotic cells in medicine intervention group reduced obviously (P＜0.01). Bax level and Caspase-3 level of CPB group were obviously higher than that of sham operation group, while Bcl-2 was significantly lower than that of sham operation group (P＜0.01). Bax level and Caspase-3 level of medicine intervention group was significantly lower than that of CPB group, while Bcl-2 was significantly higher than that of CPB group (P＜0.01). Conclusion: Danhong injection can play a good cerebral protection role through lowering cerebral infarction area and neuron apoptosis rate.

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“…This conclusion is consistent with Chen Gang's report. This fully verifies the success in model establishment [5] . Cell apoptosis is one kind of "programmed cell death".…”

Section: Discussionsupporting

confidence: 67%

Cerebral protection Effect of Danhong Injection on CPB Rats

2018

2018 7th International Conference on Medical Engineering and Biotechnology (MEDEB 2018)

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“…When cerebral ischemia occurs, a decrease in blood ow due to arterial occlusion will lead to hypoxia, which quickly induce neurological de cits or death. And it not only changes the ultrastructure and function of the brain [10], but also affects the function of the lung [21]. Post stroke pulmonary infection was found to be the result of bacterial ora displacement due to the destruction of the intestinal barrier after stroke [22].…”

Section: Discussionmentioning

confidence: 99%

“…The series of reactions eventually leads to brain injury or even brain death, and infections may occur, especially in the lungs [8]. Therefore, inhibiting the development of neuroin ammation [9] and stimulating angiogenesis [10,11] are the key to recovering the brain's focal I/R response.…”

Section: Introductionmentioning

confidence: 99%

Boswellic acid and myrrh sesquiterpene alleviate hypoxic-ischemic brain injury via regulating TLR4/NF-κB and Ang Ⅰ/Ang Ⅱ/Tie signaling pathway on MCAO rats

Miao

Zhao

et al. 2020

Preprint

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Background: The frankincense and myrrh can be used in traditional Chinese medicine (TCM) clinic with the treatment of stroke, while its mechanism is still unclear. The aim of this study was to investigate the effects of boswellic acid (BA) and myrrh sesquiterpene (MS) compositions on ischemic stroke in rats. Methods: The ischemic stroke rat model induced by ischemia-reperfusion (I/R) after transient middle cerebral artery occlusion (MCAO) was adopted and treated with boswellic acid and myrrh sesquiterpenes with proportions compatibility (BA-MS) of 10:1, 5:1 and 20:1. Biochemical indexes, histopathological analysis, metabolomics analysis of plasma and urine, as well as 16S rDNA sequencing of gut microbiota and short chain fatty acids were investigated. Results: BA and MS could obviously significantly ameliorated neurological deficits scores, reduced cerebral infarction area in I/R, and improve the damage of brains and lungs of MCAO rats. Additionally, it could significantly reduce the expression of neuroinflammatory factors (IL-1β, nNOS, BDNF, NGF) and angiogenic growth factors (ET-1, PAI-1, PDGF, VEGF, VWF), and significantly increase the expression of nerve indicators (TDP-43, NeuN) and angiogenic growth factors (Ang Ⅱ, TGF-β1, bFGF). After the administration of BA-MS, the metabolites of ischemic stroke in plasma and urine of ischemic stroke of rats were reversed, mainly correlated with the metabolic pathway of linoleic acid metabolism (impact value =1), and the gut microbiota and SCFAs metabolism of cecal contents were also improved. Conclusions: BA-MS can improve brain injury of MCAO rats via Ang/Tie and TLR4 signaling pathway, improve metabolism disorder by regulating linoleic acid metabolism pathway, and ameliorate gut microbes and their metabolic disorders.

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“…In addition to being used alone for cerebral I/R injury, the combination of DHI and Naoxintong capsule (NXT) also protects against rat cerebral I/R injury. This protective effect may be related to increased expression of chemokines and angiogenic growth factor [95].…”

Section: Experimental Studies and Molecular Mechanismsmentioning

confidence: 99%

Danhong injection in cardiovascular and cerebrovascular diseases: Pharmacological actions, molecular mechanisms, and therapeutic potential

Feng

Wang

et al. 2019

Pharmacological Research

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Cardiovascular and cerebrovascular diseases are the main cause of mortality worldwide, currently with less than optimum therapeutic options. Danhong injection (DHI) is a medicinal preparation based on two eminent Chinese herbal medicines, Salviae Miltiorrhizae (Dan Shen; family: Lamiaceae) and Flos Carthami (Hong Hua; family: Compositae/Asteraceae). DHI has been mainly used in the clinical therapy of cardiovascular (such as acute coronary syndrome and angina pectoris) and cerebrovascular diseases (such as stroke) in China for many years. The pharmacological properties of DHI include anti-inflammatory, anti-oxidant, anti-coagulatory, hypolipidemic, anti-apoptotic, vasodilatory, and angiogenesis-promoting actions. DHI offers a safe and effective therapeutic agent against cardiovascular and cerebrovascular diseases by modulating multiple disease-relevant signaling pathways and molecular targets. Herein, we provide a comprehensive review of the phytochemistry, therapeutic effects, molecular mechanisms, and adverse reactions of DHI in cardiovascular and cerebrovascular diseases. We also highlight the latest pharmacological advances and therapeutic potential of this promising herb-derived cardiovascular drug preparation.

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Protective effect of Danhong Injection combined with Naoxintong Capsule on cerebral ischemia-reperfusion injury in rats

Cited by 38 publications

References 38 publications

Cerebral protection Effect of Danhong Injection on CPB Rats

Cerebral protection Effect of Danhong Injection on CPB Rats

Boswellic acid and myrrh sesquiterpene alleviate hypoxic-ischemic brain injury via regulating TLR4/NF-κB and Ang Ⅰ/Ang Ⅱ/Tie signaling pathway on MCAO rats

Danhong injection in cardiovascular and cerebrovascular diseases: Pharmacological actions, molecular mechanisms, and therapeutic potential

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