Protective effect of curcuminoids on age-related mitochondrial impairment in female Wistar rat brain

Rastogi, Manisha; Ojha, Rudra P.; Sagar, Chandrasekhar; Agrawal, Aruna; Dubey, Govind Prasad

doi:10.1007/s10522-013-9466-z

Cited by 24 publications

(7 citation statements)

References 45 publications

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“…The ability of polyphenols to activate lysosomal biogenesis and increase longevity make them an important class of neuroprotective compounds [5,34,37]. In addition, some of the polyphenols like EGCG and curcuminoids reduced the lipofuscin granules in cells, which normally are impossible to degrade or exocytose from the cell [15,289]. Reduction of lipofuscin in the cell can contribute to the restoration of the protein homeostasis by reducing the damage to autophagosomes and proteasomes.…”

Section: Multiple Targets Of Polyphenols Against Admentioning

confidence: 99%

Dietary Polyphenols: A Multifactorial Strategy to Target Alzheimer’s Disease

Dhakal

Kushairi

Phan

et al. 2019

IJMS

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Ageing is an inevitable fundamental process for people and is their greatest risk factor for neurodegenerative disease. The ageing processes bring changes in cells that can drive the organisms to experience loss of nutrient sensing, disrupted cellular functions, increased oxidative stress, loss of cellular homeostasis, genomic instability, accumulation of misfolded protein, impaired cellular defenses and telomere shortening. Perturbation of these vital cellular processes in neuronal cells can lead to life threatening neurological disorders like Alzheimer’s Disease, Parkinson’s Disease, Huntington’s Disease, Lewy body dementia, etc. Alzheimer’s Disease is the most frequent cause of deaths in the elderly population. Various therapeutic molecules have been designed to overcome the social, economic and health care burden caused by Alzheimer’s Disease. Almost all the chemical compounds in clinical practice have been found to treat symptoms only limiting them to palliative care. The reason behind such imperfect drugs may result from the inefficiencies of the current drugs to target the cause of the disease. Here, we review the potential role of antioxidant polyphenolic compounds that could possibly be the most effective preventative strategy against Alzheimer’s Disease.

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Section: Multiple Targets Of Polyphenols Against Admentioning

confidence: 99%

Dietary Polyphenols: A Multifactorial Strategy to Target Alzheimer’s Disease

Dhakal

Kushairi

Phan

et al. 2019

IJMS

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“…Curcumin protects mitochondria from noxious factors such as oxidative stress and rotenone (inhibitor of electron transport chain) in vitro (Daverey and Agrawal, 2016 ; Ramkumar et al, 2017 ). It also alleviates the age-associated loss of mitochondrial and oxidative activity in rodent brains (Dkhar and Sharma, 2010 ; Eckert et al, 2013 ; Rastogi et al, 2014 ). Curcumin also was shown to stimulate Sirt1 and Bcl-2 expression and to decrease brain cell death in experimental stroke (Miao et al, 2016 ).…”

Section: Selected Prominent Medicinal Plants and Plant Genera Used Fomentioning

confidence: 99%

Ethnopharmacological Approaches for Dementia Therapy and Significance of Natural Products and Herbal Drugs

Tewari

Stankiewicz

Mocan

et al. 2018

Front. Aging Neurosci.

110

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Dementia is a clinical syndrome wherein gradual decline of mental and cognitive capabilities of an afflicted person takes place. Dementia is associated with various risk factors and conditions such as insufficient cerebral blood supply, toxin exposure, mitochondrial dysfunction, oxidative damage, and often coexisting with some neurodegenerative disorders such as Alzheimer's disease (AD), Huntington's disease (HD), and Parkinson's disease (PD). Although there are well-established (semi-)synthetic drugs currently used for the management of AD and AD-associated dementia, most of them have several adverse effects. Thus, traditional medicine provides various plant-derived lead molecules that may be useful for further medical research. Herein we review the worldwide use of ethnomedicinal plants in dementia treatment. We have explored a number of recognized databases by using keywords and phrases such as “dementia”, “Alzheimer's,” “traditional medicine,” “ethnopharmacology,” “ethnobotany,” “herbs,” “medicinal plants” or other relevant terms, and summarized 90 medicinal plants that are traditionally used to treat dementia. Moreover, we highlight five medicinal plants or plant genera of prime importance and discuss the physiological effects, as well as the mechanism of action of their major bioactive compounds. Furthermore, the link between mitochondrial dysfunction and dementia is also discussed. We conclude that several drugs of plant origin may serve as promising therapeutics for the treatment of dementia, however, pivotal evidence for their therapeutic efficacy in advanced clinical studies is still lacking.

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“…It was additionally reported that curcumin seems to exert its beneficial role against neuroinflammation-mediated aging in different models of AD and PD [165,166]. Moreover, it was shown that curcuminoid inhibited age-associated mitochondrial impairment in rats [167] where 100 mg/kg orally-treated curcuminoid inhibited age-associated enzymes such as cytochrome c oxidase, Complex I, NADH dehydrogenase and total ATP content. The curcuminoid, in this way, seems to suppress neuronal-NOS in mitochondria.…”

Section: Curcumin As Nutraceutical Compound In Inflammaging and Brain Inflammagingmentioning

confidence: 96%

Inflammaging and Brain: Curcumin and Its Beneficial Potential as Regulator of Microglia Activation

et al. 2022

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Inflammaging is a term used to describe the tight relationship between low-grade chronic inflammation and aging that occurs during physiological aging in the absence of evident infection. This condition has been linked to a broad spectrum of age-related disorders in various organs including the brain. Inflammaging represents a highly significant risk factor for the development and progression of age-related conditions, including neurodegenerative diseases which are characterized by the progressive dysfunction and degeneration of neurons in the brain and peripheral nervous system. Curcumin is a widely studied polyphenol isolated from Curcuma longa with a variety of pharmacologic properties. It is well-known for its healing properties and has been extensively used in Asian medicine to treat a variety of illness conditions. The number of studies that suggest beneficial effects of curcumin on brain pathologies and age-related diseases is increasing. Curcumin is able to inhibit the formation of reactive-oxygen species and other pro-inflammatory mediators that are believed to play a pivotal role in many age-related diseases. Curcumin has been recently proposed as a potential useful remedy against neurodegenerative disorders and brain ageing. In light of this, our current review aims to discuss the potential positive effects of Curcumin on the possibility to control inflammaging emphasizing the possible modulation of inflammaging processes in neurodegenerative diseases.

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Protective effect of curcuminoids on age-related mitochondrial impairment in female Wistar rat brain

Cited by 24 publications

References 45 publications

Dietary Polyphenols: A Multifactorial Strategy to Target Alzheimer’s Disease

Dietary Polyphenols: A Multifactorial Strategy to Target Alzheimer’s Disease

Ethnopharmacological Approaches for Dementia Therapy and Significance of Natural Products and Herbal Drugs

Inflammaging and Brain: Curcumin and Its Beneficial Potential as Regulator of Microglia Activation

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