Protective Effect of Cochlospermum tinctorium A. Rich Extract versus Aflatoxin B Induced Liver Damage in Rats

Dalvi, R. R.; Séré, Aminata

doi:10.3109/13880208809053903

Cited by 9 publications

(9 citation statements)

References 9 publications

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“…A variety of physical and chemical agents have been reported to reduce AFB 1 -induced hepatotoxicity via different mechanisms. [38,39] Some agents interfere with AFB 1 absorption, biotransformation and covalent binding to cellular macromolecules, others enhance the detoxifi cation of toxin through conjugation or through quite different and unknown mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Effect of oral administration of ethanolic root extract of Tinospora cordifolia on aflatoxin B₁-induced toxicity in swiss albino mice

Sharma¹,

Sharma²,

Gupta³

2011

J Nat Pharm

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Background: Afl atoxins are potent hepatotoxic and hepatocarcinogenic agents. This hepatotoxicity is thought to be mediated by their ability to generate reactive oxygen species and cause peroxidative damage. Considering the antioxidant properties of Tinospora cordifolia, this study was undertaken to evaluate the therapeutic effi cacy of Tinospora cordifolia root extract in terms of altered biochemical, hematological, serological and histopathological parameters. Methods: Sixty male swiss albino mice were taken for post exposure therapy. Results: Afl atoxin exposure elicited a signifi cant escalation in the level of thiobarbituric acid reactive substances and depletion in reduced glutathione, protein, ascorbic acid and antioxidant enzymes, namely, superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione S-transferase activities. Chronic afl atoxin ingestion showed a signifi cant decline in total erythrocyte count, lymphocyte count, hemoglobin, hematocrit values while total leukocyte count, platelet count and neutrophil count signifi cantly increased in the afl atoxin-treated group. The activities of aspartate transaminase, alanine transaminase and alkaline phosphate augmented signifi cantly in the serum of afl atoxin-exposed mice suggesting hepatic damage. Afl atoxin administration decreased the content of high density lipoprotein while increased the content of cholesterol, triglyceride, low density lipoprotein and very low density lipoprotein signifi cantly. Pathological examination of the liver tissue also supported the biochemical fi ndings. However, post-exposure administration of Tinospora cordifolia root extract to the afl atoxin-treated group attenuated the deranged parameters to some extent. Conclusion: This study indicated that Tinospora cordifolia can be a protective regimen for afl atoxin toxicity.

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Section: Discussionmentioning

confidence: 99%

Effect of oral administration of ethanolic root extract of Tinospora cordifolia on aflatoxin B₁-induced toxicity in swiss albino mice

Sharma¹,

Sharma²,

Gupta³

2011

J Nat Pharm

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“…The methanol and ethanol extracts exhibited antihepatotoxic effects against cytotoxicity induced by CCl 4 and galactosamine in primary cultured rat hepatocytes [26]. Pretreatment of rats with different extracts of the plant (36 mg/kg), orally, resulted in vitro and in vivo in protection against hepatotoxicity induced by CCl 4 , galactosamine and aflatoxin B1 [27]. Aqueous, hydro-ethanolic and ethanolic extracts showed significant dose-dependent hepatoprotective actions.…”

Section: Cochlospermum Tinctorium Perrex a Rich (Cochlospermaceae)mentioning

confidence: 97%

Medicinal Plants Used in Mali for the Treatment of Malaria and Liver Diseases

Haïdara

Bourdy

Tommasi

et al. 2016

Natural Product Communications

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Today, ethno-pharmacology is a very important resource in order to discover new therapies for the current diseases. Moreover, another good justification for the ethno-pharmacological approach is to obtain new, effective, less expensive and simple therapies, limiting at the same time the cost of pharmaceutical research. Two major anti-malarial drugs widely used today, i.e. quinine and artemisinin, came respectively from Peruvian and Chinese ancestral treatments reported in the traditional medicines. In this contest, there is an urgent need for the discovery of new drugs, due to the critical epidemiological situation of this disease and to the growth of resistances. In Mali, malaria and liver diseases remain one of the leading public health problems. Many medicinal plants are often used, in local traditional medicine, for the treatment at the same time of malaria and liver diseases, including hepatic syndromes, jaundice, hepatitis and other hepatic disorders. Moreover, in the local language Bamanan, the word “ Sumaya” is used both for malaria and some liver diseases. In addition, we noted that some of the improved traditional phytomedicines produced by the Department of Traditional Medicine are prescribed by modern doctors both for malaria and liver diseases. In this review, pharmacological, toxicological and phytochemical data on Argemone mexicana L. (Papaveraceae), Cochlospermum tinctorium Perr. ex A. Rich (Cochlospermaceae), Combretum micranthum G.Don (Combretaceae), Entada africana Guillet Perr. (Mimosaceae), Erythrina senegalensis A. DC (Fabaceae), Mitragyna inermis (Willd) Kuntze (Rubiaceae), Nauclea latifolia Smith syn. Sarcocephalus latifolius (Smith) Bruce (Rubiaceae), Securidaca longepedunculata Fresen (Polygalaceae), Trichilia emetica Vahl. (Meliaceae), and Vernonia colorata (Willd) Drake (Asteraceae) are reported. Some of the collected data could be used to improve the actual herbal drugs and to propose new phytomedicines for the management of malaria and liver diseases.

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“…Cochlospermaceae had initially been assumed to be of little medical importance, and the claim for efficacious cure of liver diseases was thought to be due to the suggestive appearance of the yellow juice from the roots (Poppendieck, 1981). However, Diallo et al (1987Diallo et al ( , 1992 provided objective evidence for hepatoprotective activity in aqueous extracts of C. tincforium rhizome by demonstrating that they had a protective effect on CC1,-induced hepatotoxicity in rats. Similarly, Dalvi and Sere (1988) reported that pretreatment of rats with an extract of C. tinctorium afforded protection against aflatoxin B1-induced liver damage.…”

Section: Introductionmentioning

confidence: 99%

“…However, Diallo et al (1987Diallo et al ( , 1992 provided objective evidence for hepatoprotective activity in aqueous extracts of C. tincforium rhizome by demonstrating that they had a protective effect on CC1,-induced hepatotoxicity in rats. Similarly, Dalvi and Sere (1988) reported that pretreatment of rats with an extract of C. tinctorium afforded protection against aflatoxin B1-induced liver damage. Claims for the medicinal use of C. angolense have also been supported by other laboratory studies.…”

Section: Introductionmentioning

confidence: 99%

Cochlospermum planchonii rhizome extract with hepatoprotective activity inhibits cytochrome P‐450 monooxygenases

Aliyu¹,

Okoye²,

Shier³

1995

Phytotherapy Research

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An aqueous extract of Cochlospermum planchonii rhizomes prepared in the manner used by native medical practitioners in northern Nigeria to treat jaundice protects CC14-treated rats from liver damage measured as elevated serum levels of diagnostic enzymes. The extract inhibits cytochrome P-450 monoxygenases aminopyrine-N-demethylase and aniline hydroxylase, suggesting a plausible hepatoprotective mechanism.

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Protective Effect of Cochlospermum tinctorium A. Rich Extract versus Aflatoxin B Induced Liver Damage in Rats

Cited by 9 publications

References 9 publications

Effect of oral administration of ethanolic root extract of Tinospora cordifolia on aflatoxin B₁-induced toxicity in swiss albino mice

Effect of oral administration of ethanolic root extract of Tinospora cordifolia on aflatoxin B₁-induced toxicity in swiss albino mice

Medicinal Plants Used in Mali for the Treatment of Malaria and Liver Diseases

Cochlospermum planchonii rhizome extract with hepatoprotective activity inhibits cytochrome P‐450 monooxygenases

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Protective Effect of Cochlospermum tinctorium A. Rich Extract versus Aflatoxin B Induced Liver Damage in Rats

Cited by 9 publications

References 9 publications

Effect of oral administration of ethanolic root extract of Tinospora cordifolia on aflatoxin B1-induced toxicity in swiss albino mice

Effect of oral administration of ethanolic root extract of Tinospora cordifolia on aflatoxin B1-induced toxicity in swiss albino mice

Medicinal Plants Used in Mali for the Treatment of Malaria and Liver Diseases

Cochlospermum planchonii rhizome extract with hepatoprotective activity inhibits cytochrome P‐450 monooxygenases

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Product

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Effect of oral administration of ethanolic root extract of Tinospora cordifolia on aflatoxin B₁-induced toxicity in swiss albino mice

Effect of oral administration of ethanolic root extract of Tinospora cordifolia on aflatoxin B₁-induced toxicity in swiss albino mice