Protective effect of cinnamon against acetaminophen-mediated cellular damage and apoptosis in renal tissue

Abdeen, Ahmed; Abdelkader, Afaf; Abdo, Mohamed; Wareth, Gamal; Aboubakr, Mohamed; Aleya, Lotfi; Abdel-Daim, Mohamed M.

doi:10.1007/s11356-018-3553-2

Cited by 58 publications

(42 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…6 ) compared to other kidney regions. These findings support our previous work, in which the cortex showed more damage due to oxidative stress in animal models of PM toxicity [ 7 , 35 ], acetaminophen [ 56 ], puromycin [ 57 ], gentamicin [ 58 ], cadmium [ 44 ], and mercury [ 59 ]. Taken all together, we strongly suggest that the overwhelming toxic effect of PM was mainly associated with mitochondrial dysfunction.…”

Section: Discussionsupporting

confidence: 91%

Coenzyme Q10 supplementation mitigates piroxicam-induced oxidative injury and apoptotic pathways in the stomach, liver, and kidney

Abdeen¹,

Abdelkader²,

Elgazzar³

et al. 2020

Biomedicine & Pharmacotherapy

Self Cite

View full text Add to dashboard Cite

Highlights PM produced oxidative stress in gastric, liver, and kidney tissue. PM-induced toxicity was mediated by ROS and mitochondrial dysfunction. PM enhanced the activated caspase-3 expression. CoQ10 alleviates PM-induced gastropathy and hepato-renal damage. CoQ10 might be effective in COVID-19 treatment regimen.

show abstract

Section: Discussionsupporting

confidence: 91%

Coenzyme Q10 supplementation mitigates piroxicam-induced oxidative injury and apoptotic pathways in the stomach, liver, and kidney

Abdeen¹,

Abdelkader²,

Elgazzar³

et al. 2020

Biomedicine & Pharmacotherapy

Self Cite

View full text Add to dashboard Cite

show abstract

“…Experimental design: Rats were assigned randomly into 7 equal groups (7 rats each). Group 1-3: were orally administered normal saline, cinnamon oil (400 mg kgG 1 b.wt., Abdeen et al, 2019) and parsley oil (200 mg kgG 1 b.wt., Abdellatief et al, 2017), respectively, once daily for 30 consecutive days. Group 4: rats in this group were intraperitoneally injected with GM (100 mg kgG 1 b.wt., Sadeghi et al, 2015) in the last 10 days (20-30 th day) of the experiment.…”

Section: Methodsmentioning

confidence: 99%

“…Because of its enrichment by polyphenolic compounds, cinnamon (Cinnamomum zeylanicum) is regarded as a powerful natural antioxidant. In folk medicine, cinnamon is widely used as antioxidant, anti-diabetic, anti-microbial effects and anti-inflammatory herb (Elkomy et al, 2016;Abdeen et al, 2019). The main constituents identified in the cinnamon extract and have powerful free radical scavenging activities are cinnamaldehyde, eugenol and cinnamic acid which mainly restores the redox hemostasis Corresponding Author: Mohamed Aboubakr, Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh, Elqaliobiya, 13736, Egypt, mohamed.aboubakr@fvtm.bu.edu.eg and normal cellular function (Hafizur et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Nephroprotective Effects of Cinnamon and/or Parsley Oils against Gentamicin-Induced Nephrotoxicity in Rats

Elkomy¹,

Aboubakr²,

Medhat³

et al. 2020

J. Anim. Vet. Adv.

Self Cite

View full text Add to dashboard Cite

In the present study, the nephroprotective potentials of cinnamon and/or parsley oils was assessed on gentamicin (GM)-induced nephrotoxicity in rats. About 49 male rats were assigned randomly into 7 equal groups (7 rats each). Group 1-3: were orally administered normal saline, cinnamon oil (400 mg kgG 1 b.wt.) and parsley oil (200 mg kgG 1 b.wt.), respectively, once daily for 30 consecutive days. Group 4: rats in this group were intraperitoneally injected with GM (100 mg kgG 1 b.wt.) in the last 10 days (20-30 th day) of the experiment. Group 5: rats in this group were given cinnamon and GM while rats in group 6 were administered parsley and GM. Group 7: rats in this group were administered cinnamon and parsley plus GM. At the end of the experiment, rats were sacrificed, serum samples and kidney specimens were collected for biochemical and oxidative status evaluation. Rats administered GM alone showed significant increases in serum concentrations of creatinine, urea and glucose while renal tissue levels of superoxide dismutase, catalase and glutathione reductase were significantly declined. Additionally, the malondialdehyde level was significantly elevated in kidney tissues. Also, GM administration caused renal histopathological alterations. The altered levels of various parameters provoked by GM toxicity were restored towards normal levels by cinnamon and/or parsley oils administration. These results suggested the nephroprotective potentials of cinnamon and/or parsley oils in rats, probably triggered by their antioxidant phytoconstituents.

show abstract

“…A minor fraction of the therapeutic dose is oxidized by the CYP450 hepatic enzymes to the reactive metabolite N-acetyl-p-benzoquinone-imine (NAPQI). When APAP is taken in high doses, the amount of NAPQI increases significantly, which depletes hepatic glutathione (GSH) storage and results in increased oxidative stress and mitochondrial dysfunction with decreased adenosine triphosphate (ATP; e.g., mitochondrial dysfunction, oxidative stress, inflammatory reactions) [4][5][6][7]. Moreover, cell damage is also the consequence of activating mitogen-activated protein kinase (MAPK), c-Jun-N-terminal kinase (JNK) or nuclear DNA fragmentation [8].…”

Section: Introductionmentioning

confidence: 99%

Probiotic Bacillus Spores Protect Against Acetaminophen Induced Acute Liver Injury in Rats

et al. 2020

View full text Add to dashboard Cite

Acetaminophen (APAP) is one of the most used analgesics and antipyretic agents in the world. Intoxication with APAP is the main cause of acute liver toxicity in both the US and Europe. Spore-forming probiotic bacteria have the ability to resist harsh gastric and intestinal conditions. The aim of this study was to investigate the possible protective effect of Bacillus (B) species (sp) spores (B. licheniformis, B. indicus, B. subtilis, B. clausii, B. coagulans) against hepatotoxicity induced by APAP in rats. A total of 35 rats were randomly divided into seven groups: group I served as control; group II received silymarin; group III received MegaSporeBioticTM (MSB); group IV received APAP and served as the model of hepatotoxicity; group V received APAP and silymarin; group VI received APAP and MSB; group VII received APAP, silymarin and MSB. The livers for histopathological examination and blood samples were collected on the last day of the experiment. We determined aspartate aminotransferase (AST), alanine aminotransferase (ALT) and total antioxidant capacity (TAC) levels and zonula occludens (ZO-1), tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) expression. APAP overdose increased AST and ALT. It slowly decreased TAC compared to the control group, but pretreatment with silymarin and MSB increased TAC levels. Elevated plasma concentrations were identified for ZO-1 in groups treated with APAP overdose compared with those without APAP or receiving APAP in combination with silymarin, MSB or both. The changes were positively correlated with the levels of other proinflammatory cytokines (TNF-α, IL-1β). In addition, histopathological hepatic injury was improved by preadministration of MSB or silymarin versus the disease model group. Bacillus sp spores had a protective effect on acute hepatic injury induced by APAP. Pretreatment with MSB resulted in a significant reduction in serum AST, ALT, TNF-α, IL-1β, ZO-1, TAC and also hepatocyte necrosis, similar to the well-known hepatoprotective agent—silymarin.

show abstract

Protective effect of cinnamon against acetaminophen-mediated cellular damage and apoptosis in renal tissue

Cited by 58 publications

References 49 publications

Coenzyme Q10 supplementation mitigates piroxicam-induced oxidative injury and apoptotic pathways in the stomach, liver, and kidney

Coenzyme Q10 supplementation mitigates piroxicam-induced oxidative injury and apoptotic pathways in the stomach, liver, and kidney

Nephroprotective Effects of Cinnamon and/or Parsley Oils against Gentamicin-Induced Nephrotoxicity in Rats

Probiotic Bacillus Spores Protect Against Acetaminophen Induced Acute Liver Injury in Rats

Contact Info

Product

Resources

About