The study was carried out on 45 sexually mature female albino rats at the age of 7-8 weeks and weighing 160-180; nine treatments were used in this study, where five rats were isolated for the control treatment (without infection); the remaining rats were injected (Subcutaneous) with Indian-made Alloxan, which was prepared at the time of injection at a dose of 100 mg/kg of body weight. The results showed a significant decrease in liver enzymes AST and the ALP characteristic in T3, T4, T5, T6, T7, T8, and T9, as well as a significant decrease in the ALT characteristic in T3, T5, T6, T7, and T9. Histological effects We notice severe damage to the liver tissue of alloxan-treated rats compared to the proper treatment, represented in the liver tissue by necrosis of liver cells, the presence of a blood clot, the absence of sinusoids, and the thickening of the nuclei. The results have shown that the aqueous extracts positively affect zymes and tissues in female rats.