Protective effect of catalpol on lipopolysaccharide-induced acute lung injury in mice

Fu, Kai; Piao, Taikui; Wang, Mingzhi; Zhang, Jian; Jiang, Jiuyang; Wang, Xuefeng; Liu, Hongyu

doi:10.1016/j.intimp.2014.07.011

Cited by 56 publications

(35 citation statements)

References 26 publications

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“…Some of its anti-inflammatory potential has been also discussed later sections, for example in the context of neurodegenerative, cardiovascular disorders, cancer and in hepatoprotective effect (Section 3, Section 5, Section 6, and Section 7.1). The anti-inflammatory potential of catalpol had also been reported in acute pancreatitis, hyperhomocysteinemia, diabetic complications, acute lung injury, multiple sclerosis, and various lipopolysaccharide (LPS)-induced inflammatory models [9][10][11][12]. The anti-inflammatory and antioxidant effects of catalpol are summarized in Table 1.…”

Section: Effects Of Catalpol In Inflammatory and Oxidative Stress Conmentioning

confidence: 94%

Multiple Biological Effects of an Iridoid Glucoside, Catalpol, and Its Underlying Molecular Mechanisms

et al. 2019

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Catalpol, an iridoid glucoside, is widely distributed in many plant families and is primarily obtained from the root of Rehmannia glutinosa Libosch. Rehmannia glutinosa is a plant very commonly used in Chinese and Korean traditional medicine for various disorders, including diabetes mellitus, neuronal disorders, and inflammation. Catalpol has been studied extensively for its biological properties both in vitro and in vivo. This review aims to appraise the biological effects of catalpol and their underlying mechanisms. An extensive literature search was conducted using the keyword “Catalpol” in the public domains of Google scholar, PubMed, and Scifinder. Catalpol exhibits anti-diabetic, cardiovascular protective, neuroprotective, anticancer, hepatoprotective, anti-inflammatory, and anti-oxidant effects in experimental studies. Anti-inflammatory and antioxidant properties are mostly related for its biological effect. However, some specific mechanisms are also elucidated. Elevated serotonin and BDNF level by catalpol significantly protect against depression and neurodegeneration. Catalpol demonstrated an increased mitochondrial biogenesis and activation of PI3K/Akt pathway for insulin sensitizing effect. Further, its cardiovascular protective effect was linked to PI3K/Akt, apelin/APJ and Jak-Stat pathway. Catalpol produced a significant reduction in cell proliferation and an increase in apoptosis in different cancer conditions. Overall, catalpol demonstrated multiple biological effects due to its numerous mechanisms including anti-inflammatory and antioxidant effects.

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Section: Effects Of Catalpol In Inflammatory and Oxidative Stress Conmentioning

confidence: 94%

Multiple Biological Effects of an Iridoid Glucoside, Catalpol, and Its Underlying Molecular Mechanisms

et al. 2019

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“…Catalpol, a major bioactive compound enriched by the dried root of R. glutinosa with the chemical structure previously shown [30], has been found to demonstrate broad and diverse bioactivities including neuroprotection, ameliorating cognition deficits and diabetic encephalopathy, potentially attenuating inflammation-related neurodegenerative diseases, protection against cerebral and cardiac ischemia/reperfusion injury, hepatoprotection, and radioprotection [31][32][33][34][35][36][37].…”

Section: Introductionmentioning

confidence: 99%

BDNF and COX-2 participate in anti-depressive mechanisms of catalpol in rats undergoing chronic unpredictable mild stress

Wang

Yang

Zhang

et al. 2015

Physiology & Behavior

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“…In lipopolysaccharide-stimulated alveolar macrophages, catalpol inhibited TNF-α, IL-6, IL-4 and IL-1β production [29] . Therefore, these compounds might contribute to the anti-inflammatory effects of XKA.…”

Section: Discussionmentioning

confidence: 89%

Deciphering the therapeutic mechanisms of Xiao-Ke-An in treatment of type 2 diabetes in mice by a Fangjiomics approach

et al. 2015

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Aim: Xiao-Ke-An (XKA) is a traditional Chinese medicine (TCM) formula for the treatment of type 2 diabetes (T2D), and the effective ingredients and their targets as well as the mechanisms of XKA remain to be elucidated. In this study we investigated the therapeutic mechanisms of XKA in the treatment of T2D in mice using a Fangjiomics approach. Methods: KKAy mice feeding on a high-fat diet were used as models of T2D, and were orally treated with XKA (0.75 or 1.5 g·kg -1 ·d -1 ) for 32 d. Microarray mRNA expression data were obtained from the livers of the mice. Differentially expressed genes (DEGs) were identified by reverse rate analysis and ANOVA analysis. The compounds in XKA were identified by LC-MS analysis or collected from TCM databases. The relationships between the compounds and targets were established by combining the DEGs with information derived from mining literature or herb target databases. Relevant pathways were identified through a Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis using WebGestalt. Results: The compound-target-pathway network based on compounds identified by LC-MS analysis (NCA) included 20 constituent compounds, 46 targets and 36 T2D-related pathways, whereas the compound-target-pathway network based on compounds collected from databases (NCD) consisted of 40 compounds, 68 targets and 21 pathways. In the treatment of T2D, XKA might act mainly by improving carbohydrate and lipid metabolism, as well as ameliorating insulin resistance, inflammation and diabetic vascular complications. Conclusion: The network-based approach reveals complex therapeutic mechanisms of XKA in the treatment of T2D in mice that involve numerous compounds, targets, and signaling pathways.

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Protective effect of catalpol on lipopolysaccharide-induced acute lung injury in mice

Cited by 56 publications

References 26 publications

Multiple Biological Effects of an Iridoid Glucoside, Catalpol, and Its Underlying Molecular Mechanisms

Multiple Biological Effects of an Iridoid Glucoside, Catalpol, and Its Underlying Molecular Mechanisms

BDNF and COX-2 participate in anti-depressive mechanisms of catalpol in rats undergoing chronic unpredictable mild stress

Deciphering the therapeutic mechanisms of Xiao-Ke-An in treatment of type 2 diabetes in mice by a Fangjiomics approach

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