BDNF and COX-2 participate in anti-depressive mechanisms of catalpol in rats undergoing chronic unpredictable mild stress

Wang, Junming; Yang, Lianhe; Zhang, Yue-Yue; Chunling, Niu; Cui, Ying; Feng, Weisheng; Wang, Guifang

doi:10.1016/j.physbeh.2015.08.008

Cited by 61 publications

(44 citation statements)

References 68 publications

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“…Anhedonia is one of the core symptoms of depression and it has been previously recognized that human depressed individuals show reduced responses to rewards. The depressed rats that were given antidepressant or AS extracts consumed more sucrose than the CUMS rats; these results are in alignment with previous results [32]. In a novel environment, depressed rats displayed fewer locomotor activities in open filed tests, indicating a loss of interest in external stimuli.…”

Section: Discussionsupporting

confidence: 91%

The Antidepressant Effect of Angelica sinensis Extracts on Chronic Unpredictable Mild Stress‐Induced Depression Is Mediated via the Upregulation of the BDNF Signaling Pathway in Rats

Shen

Zhang

Deng

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Angelica sinensis (AS), a traditional Chinese herbal medicine, has pharmaceutical effects on menstrual illness, cerebrovascular diseases, cardiovascular diseases, and cognitive impairments. However, until recently, few studies had explored its antidepressant effect. The current study attempts to investigate the effect of AS extracts on chronic unpredictable mild stress- (CUMS-) induced depression in rats. Male SD rats were exposed to a CUMS-inducing procedure for 5 weeks, resulting in rodent depressive behaviors that included reduced sucrose consumption and lessened sucrose preference ratios in sucrose preference test, prolonged immobility times and decreased struggling time in force swim test, and decreased locomotor activity in open field test. Moreover, the expression of brain derived neurotrophic factor (BDNF) and the phosphorylation of cAMP-response element binding protein (CREB) and extracellular signal-regulated protein kinase (ERK 1/2) were markedly decreased in the hippocampus in depressed rats. However, chronically treating the depressed rats with AS (1 g/kg) normalized their depression-related behaviors and molecular profiles. In conclusion, in the present study, we show that AS extracts exerted antidepressant effects that were mediated by the BDNF signaling pathway: in AS-treated depressed rats, the expression of the BDNF protein and the phosphorylation of its downstream targets (ERK 1/2, CREB) were upregulated in the hippocampus.

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Section: Discussionsupporting

confidence: 91%

The Antidepressant Effect of Angelica sinensis Extracts on Chronic Unpredictable Mild Stress‐Induced Depression Is Mediated via the Upregulation of the BDNF Signaling Pathway in Rats

Shen

Zhang

Deng

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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“…Therefore, in the treatment of AD, multicomponent and multitarget drugs, such as TCM, may be advantageous over single‐target drugs . To promote the expression of endogenous NTFs, TCM plays therapeutic roles on depression , cerebral ischemia , Parkinson's disease , spinal cord injury , diabetic encephalopathy , autoimmune encephalomyelitis , and AD and shows tremendous potential value in the treatment of nervous system disease. Although various preclinical reports have identified the effects of TCMs on AD, clinical evidences are still insufficient .…”

Section: Resultsmentioning

confidence: 99%

Potential therapeutic action of natural products from traditional Chinese medicine on Alzheimer's disease animal models targeting neurotrophic factors

Wei

2016

Fundamemntal Clinical Pharma

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Alzheimer's disease (AD) is a neurodegenerative disorder in which the death of brain cells leads to memory loss and cognitive decline. To reduce the death rate and improve the biological activity of neurocytes, neurotrophic factors (NTFs) exhibit therapeutic effect on AD. However, therapeutic application of exogenous NTFs in treatment of AD is largely limited due to short half-life, poor stability, etc. Various extracts of traditional Chinese medicine (TCM) have been shown to exhibit therapeutic effects on AD, and some of these effects are associated with regulation on the expression of nerve growth factor, brain-derived neurotrophic factor (BDNF), and glial cell line-derived neurotrophic factor (GDNF) and their associated receptors. This article reviews the progress on promotion of Panax ginseng, Rehmannia glutinosa Libosch., Epimedium, Polygala tenuifolia Willd, and seven other TCMs on secretion of NTFs during AD, with a view to preparation development and clinical application of these TCMs on AD.

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“…Each rat which belonged to the CUMS group was housed in one cage and subjected to one stressor one time a day (stressors included: water deprivation (15-h), cage tilt at a 45 degree angle (2-h), housing in mild damp sawdust (20-h), horizontal vibration (5-min), food deprivation (15-h), forced swim in water at 21°C (30-min) and intermittent white noise (85 dB, 3-h). All stressors lasted for 4-w and were applied at different points of time every week to avoid habituation and to provide an unanticipated feature to the stressors as described in detail previously (Shao et al, 2010; Wang et al, 2015). The control rats were housed in bigger cages (5 rats per cage) and they remained socially active.…”

Section: Methodsmentioning

confidence: 99%

Effects of α2A Adrenoceptors on Norepinephrine Secretion from the Locus Coeruleus during Chronic Stress-Induced Depression

Wang

et al. 2017

Front. Neurosci.

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Chronic stressors can often lead to the development of psychological disorders, such as depression and anxiety. The locus coeruleus (LC) is a stress sensitive brain region located in the pons, with noradrenergic neurons that project to the hypothalamus, especially the paraventricular nucleus (PVN) of the hypothalamus. The purpose of this paper is to better understand how alpha 2A-adrenoceptors (α2A-ARs) and LC-hypothalamus noradrenergic system participate in the pathophysiological mechanism of depression. In vivo norepinephrine (NE) release in the PVN triggered by electrical stimulation in the LC was detected with carbon fiber electrodes in depression model of rats induced by chronic unpredictable mild stress (CUMS). Also, the extracellular level of NE in the PVN was measured by microdialysis in vivo without any stimulation in the LC. The alpha 2-adrenoceptor (α2-AR) antagonist yohimbine and α2A-ARs antagonist BRL-44408 maleate were systemically administered to rats to determine the effects of α2A-ARs on NE release in the PVN. The peak value of elicited NE release signals in the PVN induced by electrical stimulation in the LC in the CUMS rats were lower than that in the control rats. The extracellular levels of NE in the PVN of the CUMS rats were significantly less than that of the control rats. Intraperitoneal injection of yohimbine or BRL-44408 maleate significantly potentiated NE release in the PVN of the CUMS rats. The CUMS significantly increased protein expression levels of α2A-AR in the hypothalamus, and BRL-44408 maleate significantly reversed the increase of α2A-AR protein expression levels in the CUMS rats. Our results suggest that the CUMS could significantly facilitate the effect of α2-adrenoceptor-mediated presynaptic inhibition and decrease the release of NE in the PVN from LC. Blockade of the inhibitory action of excessive α2A-adrenergic receptors in the CUMS rats could increase the level of NE in the PVN, which is effective in the treatment of depressive disorders.

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BDNF and COX-2 participate in anti-depressive mechanisms of catalpol in rats undergoing chronic unpredictable mild stress

Cited by 61 publications

References 68 publications

The Antidepressant Effect of Angelica sinensis Extracts on Chronic Unpredictable Mild Stress‐Induced Depression Is Mediated via the Upregulation of the BDNF Signaling Pathway in Rats

The Antidepressant Effect of Angelica sinensis Extracts on Chronic Unpredictable Mild Stress‐Induced Depression Is Mediated via the Upregulation of the BDNF Signaling Pathway in Rats

Potential therapeutic action of natural products from traditional Chinese medicine on Alzheimer's disease animal models targeting neurotrophic factors

Effects of α2A Adrenoceptors on Norepinephrine Secretion from the Locus Coeruleus during Chronic Stress-Induced Depression

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