Protective Effect of Cassava Leaf Extract on Gentamicin-Induced Hepatotoxity In Mice

Dewi, Rosita; Normasari, Rena

doi:10.19184/ams.v5i3.13815

Cited by 4 publications

(2 citation statements)

References 3 publications

(6 reference statements)

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“…The positive control group showed the highest results due to the administration of Gentamicin at a dose of 80 mg/kg BW for eight days without giving red ginger extract. Gentamicin causes liver cell damage which begins with the production of free radicals in the liver which cause oxidative stress [15,16]. Oxidative stress causes Gentamicin to resist phospholipid degradation which disrupts the integrity of lysosomal membranes which ends in enzyme leakage thereby increasing AST levels in the blood [17].…”

Section: The Effect Of Red Ginger Extract On Sgotmentioning

confidence: 99%

Effect of red ginger extract (Zingiber officinale var. Rubrum) of SGOT and SGPT levels in white rats (Rattus norvegicus) induced by Gentamicine

Ayuni Wardah Humairo,

Moh. Sukmanadi,

M. Gandul Atik Yuliani

et al. 2024

World J. Adv. Res. Rev.

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Introduction: The aim of the research was to prove that red ginger extract (Zingiber officinale var. Rubrum) could inhibit the increase in SGOT and SGPT levels in Gentamicin-induced rats. Objective: Twenty-five male rats aged 8-12 weeks with 150-200 gram BW divided into five groups research with C- was given CMC-Na 1% and aqua pro-injection, C+ was given 1% CMC-Na and induction of Gentamicin 80 mg/kg BW, and groups T1, T2, and T3 given induction of Gentamicin 80 mg/kg BW and red ginger extract at individual doses each of 100, 200, and 400 mg/kg BW. All treatments were carried out for 15 days. On the 16th day, all rats were euthanized and their blood was drawn intracardiacly, then SGOT and SGPT levels were examined. The results of the research used the Analysis of Variance (ANOVA) and Games-Howell statistical analysis. Results: The results showed that the C+ group experienced the highest increase (p<0.05) while the C-group experienced the lowest increase (p<0.05) compared to the other treatment groups. The T1, T2, T3 groups were able to inhibit the increase in SGOT and SGPT levels. Conclusion: The effective dose to inhibit the increase in SGOT levels is 400 mg/kg BW and the effective dose to inhibit the increase in SGPT levels is 200 mg/kg BW.

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Section: The Effect Of Red Ginger Extract On Sgotmentioning

confidence: 99%

Effect of red ginger extract (Zingiber officinale var. Rubrum) of SGOT and SGPT levels in white rats (Rattus norvegicus) induced by Gentamicine

Ayuni Wardah Humairo,

Moh. Sukmanadi,

M. Gandul Atik Yuliani

et al. 2024

World J. Adv. Res. Rev.

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“…Allium cepa contain high flavonoid. Flavonoids from other plants are known to have antioxidant activity on various organs [8,11,12,13]. Previous research shows that phenolic compound and quercetin isolated from onion peel was 3 to 5 times higher than those from its edible part [14].…”

Section: Introductionmentioning

confidence: 99%

GASTROPROTECTIVE EFFECT OF ONION PEEL (Allium Cepa L. Var Ascalonicum) EXTRACT ON WISTAR RATS INDUCED BY MEFENAMIC ACID

Putri

Helianti

Rumastika

2020

ICATD

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Non Steroidal Anti-inflammatory Drugs (NSAID) have been implicated in the etiology of gastritis. Mefenamic acid is a non-selective NSAID used to treat mild to moderate pain and inflammation. Mefenamic acid induces gastritis through its inhibition of prostaglandin that results in increased HCl secretion, decreased mucin, and bicarbonate ion production. This study aimed to investigate the gastroprotective effect of onion peel extract (OPE) against mefenamic acid-induced gastritis. In this study, the gastroprotective effect of OPE was examined through mucosal integrity scoring. A total of 28 male Wistar rats were divided into 4 groups, normal (Group 1), mefenamic acid+NaCMC 0,5% (Group 2), mefenamic acid+OPE 600mg/kg body weight (Group 3), and mefenamic acid+OPE 1200mg/kg body weight (Group 4). All rats were sacrificed on day 15 then all gasters were collected. Histopathological examination was done under a microscope with 100X magnification. Administration of mefenamic acid without OPE at all significantly increased gastric mucosal damage (p<0,05). Administration of OPE 1200mg/kg body weight significantly decreased gastric mucosal damage (p<0,05). Group 4 shows no significant difference (p=0,66) with the normal group (Group 1). This indicates that administration of OPE 1200mg/kg body weight per oral ameliorates mefenamic acid-induced gastritis.

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Alterations in serum activity of hepatocellular enzymes, levels of liver function markers, and liver histology of dogs given high (nephrotoxic) doses of gentamicin

Ezema¹,

Ihedioha²,

Num-Adom³

et al. 2022

Comp Clin Pathol

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Protective Effect of Cassava Leaf Extract on Gentamicin-Induced Hepatotoxity In Mice

Cited by 4 publications

References 3 publications

Effect of red ginger extract (Zingiber officinale var. Rubrum) of SGOT and SGPT levels in white rats (Rattus norvegicus) induced by Gentamicine

Effect of red ginger extract (Zingiber officinale var. Rubrum) of SGOT and SGPT levels in white rats (Rattus norvegicus) induced by Gentamicine

GASTROPROTECTIVE EFFECT OF ONION PEEL (Allium Cepa L. Var Ascalonicum) EXTRACT ON WISTAR RATS INDUCED BY MEFENAMIC ACID

Alterations in serum activity of hepatocellular enzymes, levels of liver function markers, and liver histology of dogs given high (nephrotoxic) doses of gentamicin

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