Protective effect of cannabis and coffee consumption on HCV-related mortality in French HIV-HCV co-infected patients (ANRS CO13 HEPAVIH cohort)

Cannabis Use Is Inversely Associated with Overweight and Obesity in Hepatitis B Virus-Infected Patients (ANRS CO22 Hepather Cohort)

“…Further investigations should be carried out to test whether the seemingly beneficial effect of cannabis use on BMI in HBV-infected patients also translates into metabolic or hepatic benefits. Moreover, as the ECS influences gastrointestinal homeostasis, direct effects of cannabis use (and/or its derivatives) on hepatic diseases should also be investigated further 45 , especially as similar effects have already been suggested by studies conducted in HIV-HCV co-infected patients 17,29,46,47 . The potential protective effect of cannabis and cannabinoids on hepatic steatosis 27,[47][48][49] is of particular interest for HBVinfected patients, as hepatic steatosis is a strong predictor of cancer and mortality in this population 50 .…”

“…The second threshold (i.e., 1 cup/day) was used to test for a potential dose-dependent relationship between coffee consumption and the outcomes. The third threshold (i.e., 3 cups or more/day) was chosen based on previous results showing a potential protective effect of coffee on liver stiffness and mortality in patients likely to develop liver disease [27][28][29] . Alcohol consumption was categorized into four categories based on the threshold for unhealthy alcohol use (defined as > 2 standard drinks per day for women and > 3 standard drinks per day for men, in accordance with the French National Authority for Health 30 ) as follows: abstinent i) with or ii) without a history of unhealthy alcohol use, iii) current unhealthy alcohol use, and iv) current moderate alcohol use (i.e., non-abstinent and non-unhealthy use).…”

Metabolic Disorders in Patients with Chronic Hepatitis B Virus Infection: Coffee as a Panacea? (ANRS CO22 Hepather Cohort)

“…Participants’ characteristics according to their coffee consumption level are provided in Table 1 . Most were men (63.3%), and the median age was 43 years (interquartile range [ 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 ]). Just over a quarter (26.8%) had elevated coffee consumption, while 39.1% had daily tea consumption.…”

“…The one cup per day threshold was used to test for a potential dose response relationship between coffee consumption and the three study outcomes. The three cups or more per day threshold was chosen based on previous results showing the potential protective effect of this level of consumption on liver stiffness and mortality in patients likely to develop liver disease [ 38 , 39 ]. Given the expected dose-response effect of coffee consumption [ 29 , 40 ], we also tested the higher threshold of four cups per day when the three cups per day threshold was not significantly associated with the outcome.…”

Cannabis use as a factor of lower corpulence in hepatitis C-infected patients: results from the ANRS CO22 Hepather cohort

“…Similarly, tobacco use was divided into “current use,” “former use,” and “never.” Coffee consumption was defined as none (0 cups per day), moderate (1–2 cups per day), or elevated (≥ 3 cups per day). The 3 cups/day threshold was chosen based on previous results showing a potential protective effect of coffee consumption on liver stiffness and mortality in patients likely to develop liver disease (Carrieri et al 2018 ; 2017a ; Protopopescu et al 2018 ). Alcohol consumption was classified into the following three categories based on the threshold for unhealthy alcohol use (defined as > 2 and > 3 standard drinks per day for women and men, respectively, in accordance with the French National Authority for Health (Haute Autorité de Santé (French National Authority for Health) 2014 )): (i) abstinent with no history of unhealthy use, (ii) current moderate alcohol use (i.e .…”