Protective Effect of Caffeic Acid Phenethyl Ester on Cadmium-Induced Liver Toxicity: A Histopathological and Biochemistry Study

Abstract

In this study, the changes caused by caffeic acid phenethyl ester (CAPE) in histopathological and biochemical parameters in oxidant / antioxidant balance in mice with experimental cadmium toxicity were investigated. In blood samples from mice, plasma paraoxonase (PON) activity, high density lipoprotein (HDL), low density lipoprotein (LDL), total sialic acid (TSA) total antioxidant capacity (TAC), total oxidant capacity (TOC) and oxidative stress index (OSI) ) values ​​were analyzed. In this study, it was found that cadmium intoxication triggered oxidative stress in mice, lowering PON activity, TAC, HDL levels and increasing TSA, LDL, TOC, OSI levels. In the histopathological examination of the liver tissues, focal apoptotic regions, sinusoidal occlusion and irregularity were found in the cadmium group, while no significant change was found in the other groups. According to these results, it has been shown that CAPE can significantly prevent biochemical and histopathological changes due to cadmium damage.

Evaluation of Oxidative Stress Index and Some Biochemical Parameters in Neonatal Calves with Diarrhea

“…They neutralize free radicals and oxidize themselves by accepting highly reactive unpaired electrons [10,[27][28][29]. It has been indicated by experimental evidence that varied antioxidants play an important role against oxidants in many studies [30][31][32][33][34][35][36][37][38]. The results of the presented study showed that diarrhea caused oxidative stress in calves with diarrhea.…”