Protective effect of Bojungbangdocktang on cisplatin-induced cytotoxicity and apoptosis in MCF-10A breast endothelial cells

Kang, Sang-Hun; Lee, Hyo‐Jung; Jeong, Soo‐Jin; Kwon, Hee Young; Kim, Jihyun; Yun, Sun-Mi; Kim, Jinhyung; Lee, Hyo‐Jeong; Lee, Eun-Ok; Ahn, Kwang Seok; Ahn, Kyoo Seok; Kim, Sung Hoon

doi:10.1016/j.etap.2009.07.007

Cited by 12 publications

(7 citation statements)

References 28 publications

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“…Two related studies [44,45] found that BJBDT demonstrated antiangiogenesis by blocking VEGF/VEGFR activities in human umbilical vein endothelial cells. Interestingly, BJBDT can prevent cisplatin-induced toxicity and apoptosis in normal MCF-10A, but not in MCF-7 and MDA MB-231 breast cancer cells, suggesting the herbal formula can be applied as a cancer chemopreventive agent [43]. The synergistic effects of herbs in a TCM formula were well illustrated in a recent study, in which a TCM-based formula, Realgar-indigo naturalis (RIF), was applied in the treatment of acute promyelocytic leukemia (APL).…”

Section: Molecular Mechanisms Of Tcm-based Herbal Medicines As Anticamentioning

confidence: 99%

“…In the same study, GZFLD was also shown to inhibit tumor growth and angiogenesis in an in vivo animal model. Another report [43] concerned a classic formula "bojungbangdocktang (BJBDT)" consisting of Astragalus membranaceus Bunge, Atractylodes japonica Koidzumi, Coiz lacryma-jobi Linne var. ma-yuen stapf, Dioscorea batatas Decaisne, Dolichos lablab Linne, Panax ginseng C. A. Mey, Polygonatum sibiricum Delar.…”

Section: Molecular Mechanisms Of Tcm-based Herbal Medicines As Anticamentioning

confidence: 99%

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The Role of Traditional Chinese Herbal Medicines in Cancer Therapy – from TCM Theory to Mechanistic Insights

Hsiao¹,

Liu²

2010

Planta Med

262

187

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Section: Molecular Mechanisms Of Tcm-based Herbal Medicines As Anticamentioning

confidence: 99%

Section: Molecular Mechanisms Of Tcm-based Herbal Medicines As Anticamentioning

confidence: 99%

The Role of Traditional Chinese Herbal Medicines in Cancer Therapy – from TCM Theory to Mechanistic Insights

Hsiao¹,

Liu²

2010

Planta Med

262

187

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“…Interestingly, several medicinal herbs exhibited the potential to promote hematopoiesis (Lu and Jia, 2000; Currier and Miller, 2001; Singh et al ., 2006). Thus, for combined therapy potential with anticancer agents, the hematopoietic mechanisms of Bojungbangdocktang (BJBDT) with antiangiogenic and apoptotic activities (Jang et al ., 2009; Kang et al ., 2009) were evaluated in vitro and in vivo in the current study.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, several medicinal herbs such as Tinospora cordifolia whole plant, Echinacea purpurea root extract and naturin 2 showed the potential to promote hematopoiesis (Lu and Jia, 2000; Currier and Miller, 2001; Singh et al ., 2006). Bojungbangdocktang (BJBDT), a modified herbal formula (Lee et al ., 1994, 2007) was reported to have antiangiogenic and apoptotic activities (Jang et al ., 2009; Kang et al ., 2009). Interestingly, Astragalus membranaceus and Panax ginseng , components of BJBDT, have been reported to induce the hematopoiesis in vitro and in vivo (Zhu and Zhu, 2001; Chen et al ., 2003; Lv et al ., 2005; Fang et al ., 2007; Zhu and Zhu, 2007; Chen et al ., 2009).…”

Section: Introductionmentioning

confidence: 99%

JAK2/STAT5 signaling pathway mediates Bojungbangdocktang enhanced hematopoiesis

Lim

Jeong

Koh

et al. 2011

Phytotherapy Research

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Bojungbangdocktang (BJBDT) is a medicinal herbal cocktail that has been used for cancer prevention and treatment in traditional Korean medicine. In the current study, BJBDT was demonstrated to regulate hematopoiesis. BJBDT significantly increased the expression of hematopoietic cytokines interleukin (IL)-3, stem cell factor (SCF), granulocyte-macrophage-colony stimulating factor (GM-CSF), thrombopoietin (TPO) and erythropoietin (EPO) at the level of mRNA and secretion in hematopoietic stem cells (HSCs). Additionally, BJBDT enhanced the phosphorylation of Janus activated kinase 2 (JAK2) and signal transducer and activator of transcription 5 (STAT5) and STAT binding to gamma interferon activated sites (GAS) in HSCs. Furthermore, BJBDT significantly enhanced the growth rate of granulocyte erythrocyte monocyte macrophage colony-forming units (CFU-GEMM) and erythroid burst forming units (BFU-E) in vitro. Moreover, BJBDT increased the level of EPO at mRNA in kidney and plasma, and the numbers of erythroid-specific antigen Ter-119(+) erythroid cells in mice with aplastic anemia induced by 20% benzene. Consistently, histochemical staining revealed BJBDT increased the bone marrow and stromal cells as well as decreased macrophages and adipocytes in bone marrow tissues of mice with aplastic anemia. Taken together, the results suggest that BJBDT can enhance hematopoiesis via hematopoietic cytokine-mediated JAK2/STAT5 pathway as a potent hematopoietic candidate. Copyright © 2010 John Wiley & Sons, Ltd.

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“…In addition, Bojungbangdocktang (BJBDT), which has been used for the prevention or treatment of cancers in Korea, functions by blocking VEGF/VEGFR activity to inhibit angiogenesis in human umbilical vein endothelial cells (HUVECs) [ 8 ]. It also prevents cisplatin-induced toxicity and apoptosis in MCF-10A normal human breast epithelial cells, but not in breast cancer cells [ 9 ]. These results strongly suggest that herbal medicines have potentially beneficial effects on cancer progression and ameliorate conventional chemotherapy- or radiotherapy-induced complications.…”

Section: Introductionmentioning

confidence: 99%

Jaeumganghwa-Tang Induces Apoptosis via the Mitochondrial Pathway and Lactobacillus Fermentation Enhances Its Anti-Cancer Activity in HT1080 Human Fibrosarcoma Cells

Kim

Hwang

et al. 2015

PLoS ONE

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Jaeumganghwa-tang (JGT, Zi-yin-jiang-huo-tang in Chinese and Jiin-koka-to in Japanese) is an oriental herbal formula that has long been used as a traditional medicine to treat respiratory and kidney diseases. Recent studies revealed that JGT exhibited potent inhibitory effects on allergies, inflammation, pain, convulsions, and prostate hyperplasia. Several constituent herbs in JGT induce apoptotic cancer cell death. However, the anti-cancer activity of JGT has not been examined. In this study, we investigated the anti-cancer effects of JGT using highly tumorigenic HT1080 human fibrosarcoma cells and elucidated the underlying mechanisms. In addition, we examined whether the Lactobacillus fermentation of JGT enhanced its anti-cancer activity using an in vivo xenograft model because fermentation of herbal extracts is thought to strengthen their therapeutic effects. Data revealed that JGT suppressed the growth of cancer cells efficiently by stimulating G1 cell cycle arrest and then inducing apoptotic cell death by causing mitochondrial damage and activating caspases. The phosphorylation of p38 and ERK also played a role in JGT-induced cell death. In vitro experiments demonstrated that JGT fermented with Lactobacillus acidophilus, designated fJGT162, elicited similar patterns of cell death as did non-fermented JGT. Meanwhile, the daily oral administration of 120 mg/kg fJGT162 to HT1080-bearing BALB/c nude mice suppressed tumor growth dramatically (up to 90%) compared with saline treatment, whereas the administration of non-fermented JGT suppressed tumor growth by ~70%. Collectively, these results suggest that JGT and fJGT162 are safe and useful complementary and alternative anti-cancer herbal therapies, and that Lactobacillus fermentation improves the in vivo anti-cancer efficacy of JGT significantly.

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Protective effect of Bojungbangdocktang on cisplatin-induced cytotoxicity and apoptosis in MCF-10A breast endothelial cells

Cited by 12 publications

References 28 publications

The Role of Traditional Chinese Herbal Medicines in Cancer Therapy – from TCM Theory to Mechanistic Insights

The Role of Traditional Chinese Herbal Medicines in Cancer Therapy – from TCM Theory to Mechanistic Insights

JAK2/STAT5 signaling pathway mediates Bojungbangdocktang enhanced hematopoiesis

Jaeumganghwa-Tang Induces Apoptosis via the Mitochondrial Pathway and Lactobacillus Fermentation Enhances Its Anti-Cancer Activity in HT1080 Human Fibrosarcoma Cells

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