Protective effect of basil (Ocimum basilicum L.) against oxidative DNA damage and mutagenesis

Ultrasound assisted maceration: An original procedure for direct aromatisation of olive oil with basil

“…Common examples are rosemary (Erkan, Ayranci, & Ayranci, 2008;Genena, Hense, Smania Junior, & De Souza, 2008) or thyme (Youdim & Deans, 1999) and at lower level, some compounds of basil essential oil have also demonstrated antioxidant and preservative capacities (Bagamboula, Uyttendaele, & Debevere, 2004;Beric, Nikolic, Stanojevic, Vukovic-Gacic, & Knezevic-Vukcevic, 2008;Lee, Umano, Shibamoto, & Lee, 2005;Suppakul, Miltz, Sonneveld, & Bigger, 2003). Nevertheless, basil (Ocinum basilicum L.) is mostly used as culinary herb for its characteristic aroma or in perfumery.…”

Molecular Mechanisms of Action of Antimutagens from Sage (Salvia officinalis) and Basil (Ocimum basilicum)

“…Antimutagenic potential determined in all tests was tentatively attributed to antioxidative properties and indicated Lin as principal active substance. The confirmation of proposed mechanism was obtained in oxyR deficient IC202 strain, where reduction of t-BOOH-induced mutagenesis was 72% and 70%, for EO and Lin, respectively [86]. …”

“…Therefore, we could conclude that stronger protective effect was obtained in cells with reduced antioxidative capacity, similarly as in bacteria. Protective effect of Lin in eukaryotic cells was also reported by Berić et al [86]. In the comet assay performed on S. cerevisiae 3A diploid strain, Lin significantly reduced H2O2-induced DNA damage.…”

“…No reduction of spontaneous mutagenesis was detected, even in the strain with increased sensitivity (mutS). However, Berić et al [86] reported the inhibition of spontaneous mutagenesis in isogenic mutH strain. Similar discrepancy between responses obtained in different MMR mutants was already noted by Vuković-Gačić and Simić [28].…”

“…Obtained results showed that applied doses induced DNA lesions, providing direct confirmation of genotoxicity of Cam, Euc and Thu ( Figure 11). The genotoxicity of high concentrations of Lin was previously determined in comet assay on yeast cells [86].…”