Protective effect of Aquilegia vulgaris (L.) against lead acetate-induced oxidative stress in rats

El‐Nekeety, Aziza A.; El-Kady, Ahmed A.; Soliman, Mahmoud E.; Hassan, Nabila S.; Abdel-Wahhab, Mosaad A.

doi:10.1016/j.fct.2009.06.019

Cited by 119 publications

(94 citation statements)

References 55 publications

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“…On the other hand, urea and creatinine are considered as biomarkers of the first and advancing stages of kidney damage, respectively [29] . In this study, PbActreated mice showed increase in plasma creatinine and urea levels, which may reflect the renal failure onset [30] .…”

Section: Resultsmentioning

confidence: 99%

Nephroprotective Effects of Berberis Vulgaris L. Total Extract on Lead Acetate-induced Toxicity in Mice

Laamech¹,

El-Hilaly²,

Fetoui³

et al. 2016

pharmaceutical-sciences

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Laamech, et al.: Berberis vulgaris Effect on Lead Nephrotoxicity in MiceThis study aimed to investigate the potential effects of Berberis vulgaris L. against lead acetate-induced nephrotoxicity in Swiss albino mice. Mice were exposed chronically to lead acetate, at a dose of 5 mg/kg, alone or in conjunction with B. vulgaris extract (25, 50, 100 and 150 mg/kg). Lead acetate administration increased lead burden in blood and kidneys, altered renal biomarkers (serum creatinine, urea and uric acid), increased malondialdehyde and protein carbonyls levels, and decreased reduced glutathione, glutathione peroxidase, catalase, and superoxide dismutase. Histological studies showed glomerular degeneration and hypercellularity. However, B. vulgaris extract co-treatment significantly and dose-dependently restored the renal parameters, antioxidant enzymes, and histopathological changes near to the normal status, mainly via its antioxidant properties and/or by preventing lead bioaccumulation. Therefore, B. vulgaris extract showed nephroprotective effects against lead-induced nephrotoxicity mainly through its antioxidant and metal chelating properties.

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Section: Resultsmentioning

confidence: 99%

Nephroprotective Effects of Berberis Vulgaris L. Total Extract on Lead Acetate-induced Toxicity in Mice

Laamech¹,

El-Hilaly²,

Fetoui³

et al. 2016

pharmaceutical-sciences

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show abstract

“…Also It has been showed that liver is recognized as the major organs involved in the storage, biotransformation and detoxification of toxic substances, is of interest in heavy metal poisoning [22]. Besides that the toxicity of L.A. cause free radical formation by generation of reactive oxygen species (ROS) , and the direct depletion of antioxidant reserves [23]. Our result is agreed with the findings of [24] who suggested that sinusoidal blood congestion after treatment with lead is an indicator of liver damage.…”

Section: Livermentioning

confidence: 99%

Effect of Testosterone on Lead Acetate Toxicity in Male Albino Rats

Mahmood

Hamad

Hassan

et al. 2017

KJAR

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Abstract:The toxicity of lead acetate (L. A.) concerned to public health disruptor due to its persistence in the environment and it has the adverse influence on the human and animal health as well. It causes physiological,biochemical, and neurological dysfunctions in humans. Histologically it has a negative effect on the liver which is considered one of the major target organs where acts as detoxification machine by elimination the toxic substance from the blood in rich with it. As well as it affects kidneys that are the two of the most filtering organs. Therefore the present study was aimed to investigate the histopathological effect of L.A. on liver and kidney tissues in male rats. Twenty male rats involved in the study were equally and randomly divided into two groups each of them involved 10 animals. Group I (castrated rats) and Group II (control) each group received 80mg/L of lead acetate dissolved in one liter distilled water by drinking for 15 days. Histological sections showed some alterations including abnormal architecture, cell degeneration, nuclear degeneration, hyperchromatic hepatocytes, immune cells, degeneration in tubules, dilation in sinusoids, dilation in central vein of liver increased bowman's space glomerular atrophy degeneration of tubular cells in liver and kidney tissues of rats in castrated rats from control group. But the size of degenerated tissue was more severe in castrated male rats. It was concluded that the castration process could produce a hypogonadism and decreased testosterone which owns many receptors in kidney and liver may produce adverse influence with L.A. administration.

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“…Sources of human exposure to this metal include many foods, drinking water, and dust (El-Nekeety et al, 2009). Pregnant women, children, and city inhabitants are at risk of lead intoxication.…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical and Histopathological Changes in the Skin of Rats after Administration of Lead Acetate

et al. 2016

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DEVECI, E.; ÖZEVREN, H.; EKINCI, C. & ELBEY, B.Immunohistochemical and histopathological changes in the skin of rats after administration of lead acetate. Int. J. Morphol., 34(3):918-922, 2016. SUMMARY:Lead acetate is a chemical compound. Sources of human exposure to this metal include many foods, drinking water and dust. The aim of this study was to determine the immunohistochemical and histopathological changes on the face skin after lead acetate application. Wistar Albino rats (180-200 g body weight) were divided into a controlled and lead acetate-exposed group. Rats received lead acetate at 500 ppm in their drinking water for 60 days. Both groups were fed with the same standard food, but lead acetate was added to the drinking water. During the experimental period, blood samples were drawn from the abdominal aorta of the anesthetised animals. At the end of exposure, body weight and blood lead levels were measured. Sections of rat facial skin were examined histopathological and immunohistochemical. In the group treated with lead acetate, minimal to slight multifocal hydropic degeneration of basal cell layer, depending on the thinning of the epidermis, the cellular degeneration in the dermis and a increase in the number of necrotic cells was observed in sebaceous glands of the hair follicle hemorrhage. The immunohistochemical results of the present work demonstrated an increase in Proliferating cell nuclear antigen (PCNA) immunoreactivity in skin specimens from lead acetate treated animals. Vimentin immunoreactivity was very dense in hair follicle of the subepidermal region. It was also strongly stained around the myoepithelial cells surrounding sebaceous and stromal cells.

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Protective effect of Aquilegia vulgaris (L.) against lead acetate-induced oxidative stress in rats

Cited by 119 publications

References 55 publications

Nephroprotective Effects of Berberis Vulgaris L. Total Extract on Lead Acetate-induced Toxicity in Mice

Nephroprotective Effects of Berberis Vulgaris L. Total Extract on Lead Acetate-induced Toxicity in Mice

Effect of Testosterone on Lead Acetate Toxicity in Male Albino Rats

Immunohistochemical and Histopathological Changes in the Skin of Rats after Administration of Lead Acetate

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