Protective effect of aprotinin on ischemia–reperfusion injury in rat ovary

Abstract

Aprotinin attenuates ischemia-reperfusion injury in a rat adnexial torsion-detorsion model.

Protective effects of tempol in an experimental ovarian ischemia–reperfusion injury model in female Wistar albino rats

“…Reactive oxygen species stimulate neutrophils and can cause further damage to the cells of ischemic tissues, mainly due to lipid peroxidation in cellular and mitochondrial membranes (Ozat et al 2009;Sahin et al 2008;Somuncu et al 2008;Zweier 1987). Reactive oxygen species also attack DNA in the nucleus and destruct cell membrane (Sadoshima 2008 that the MDA levels indicating oxidative stress significantly decreased in the colchicineadministered group, similar to our study (Keskin et al 2015).…”

The Ovario-Protective Effect of Erythropoietin against Oxidative Damage Associated with Reperfusion Following Ovarian Torsion in Rat

“…Regarding these observations even after immediate surgical intervention, however, when encountering with a twisted adnexa, the best intervention to save ovarian function has not been elucidated yet. Several antioxidant supplementations have been investigated in reducing the ischemic effect of OT on reperfusion injury in a controlled experimental rat torsion-detorsion model, including Melatonin Labibzadeh and Sadrnejad, 2007a), Aprotinin (Sahin et al, 2008), α-lipoic acid (Cosar et al, 2007), Genistein (Yazici et al, 2007), Iloprost (Ozat et al, 2009) Marrubium cordatum extract (Cigremis et al, 2009). Natural antioxidants have also been examined in testicular torsion.…”

Does sildenafil have protective effects against ovarian ischemia-reperfusion injury in rats?

“…h Decreases hemorrhage, interstitial edema and congestion in torsion-detorsion ? sildenafil (1.4 mg/ kg) group Arch Gynecol Obstet in the neutrophil infiltration, production of nitric oxide, cytokines and FOR in ovarian tissue [3,15,16]. In this case, it is described as IRD, which actually causes more tissue damage when compared to ischemia [3,4].…”