Does sildenafil have protective effects against ovarian ischemia-reperfusion injury in rats?

Incebiyik, Adnan; Şeker, Ahmet; Camuzcuoğlu, Hakan; Kocaslan, Sezen; Camuzcuoğlu, Aysun; Hilali, Neşe Gül; Vural, Mehmet; Taşkın, Abdullah; Aksoy, Nurten

doi:10.1007/s00404-014-3554-4

Cited by 12 publications

(9 citation statements)

References 22 publications

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“…Congestion, hemorrhage and edema were reduced similar to our study. Further they have assessed oxidative stress index [total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI)] and showed that these scores were also reduced [21]. But there were no data about the differences of follicle count and AMH levels between groups.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the protective effects of sildenafil, vardenafil and tadalafil treatments in ischemia-reperfusion injury in rat ovary

et al. 2019

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Objectives: The aim of this study was to compare the effects of sildenafil, vardenafil and tadalafil in treatment for ischemia/reperfusion injury which is created experimentally in rat ovaries. Material and methods: For this study, 30 female Wistar albino rats were used, and the rats were separated randomly into five groups consisting of six rats each: normal, torsion-detorsion, torsion-detorsion + sildenafil 1.4 mg/kg, torsion-detorsion + vardenafil 1.7 mg/kg and torsion-detorsion + tadalafil 5.0 mg/kg. The agents were given intraperitoneally 30 minutes before detorsion. An ovarian torsion procedure was implemented in all other groups for 3 hours with the exception of the normal group. Then, a detorsion procedure was implemented to the groups for 3 hours. Results: The sildenafil and vardenafil treatments showed protective effect by preventing significant increase in inflammation parameters. (p = 0.058, 0.138). The tadalafil treatment was only protective for cellular degeneration (p = 0.140). The vardenafil treatment was protective for edema (p = 0.238), vascular congestion (p = 0.111), inflammation (p = 0.138) and cellular degeneration (p = 0.532). Sildenafil, vardenafil and tadalafil inhibited the increase of atretic follicle. AMH levels were statistically different between torsion and detorsion and vardenafil group (p = 0.004, 0.004), whereas tadalafil and sildenafil groups were similar to normal group (p = 0.108, 0.108). Conclusions: PDE inhibitors were found to be effective in reducing ovarian ischemia/reperfusion injury. Sildenafil and tadalafil seem to be more effective than the vardenafil in protecting the ovarian reserve.

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Section: Discussionmentioning

confidence: 99%

Comparison of the protective effects of sildenafil, vardenafil and tadalafil treatments in ischemia-reperfusion injury in rat ovary

et al. 2019

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“…Assuming that detorsion can provoke this injury and alone is insufficient to protect ovarian reserve as the follicle count decreases (Ozler et al [38]), several agents, including antiinflammatories and antioxidant drugs, have been evaluated to determine whether they have a protective effect [36]. Experimental studies were performed on rat ovaries to demonstrate the role of different drugs in the protection of ovarian function [36,[39][40][41][42][43][44][45][46][47][48][49][50][51][52][53]. Gradual detorsion can also reduce reperfusion injury in a rat model of ovarian torsion [37].…”

Section: Effects Of Reperfusion After Detorsion: Experimental Studiesmentioning

confidence: 99%

Adnexal torsion in adolescents

Spinelli

Piscioneri

Strambi

2015

Current Opinion in Obstetrics &Amp; Gynecology

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A systematic review of physiopathology, clinical picture, and imaging of adnexal torsion is certainly useful to identify as soon as possible this emergency condition. An early identification and an adequate treatment are indispensable in order to achieve a proper outcome for the patient. The choice of the appropriate surgical approach can be challenging and should be made on the basis of an accurate evaluation of the ovarian lesion. Therefore, it would be useful to perform an intraoperative frozen section analysis in selected cases.

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“…Sildenafil, a phosphodiesterase 5 enzyme inhibitor, causes nitric oxide release from the endothelium, smooth muscle relaxation with increased cyclic guanosine monophosphate (cGMP) and vasodilatation (Kukreja et al, 2005). Due to this known effect, sildenafil has been mostly investigated in reperfusion injury in ovarian tissue and it has been found to be effective in preventing reperfusion injury after ischemia (Ganla et al, 2019;Incebiyik et al, 2015). In addition, the effect of sildenafil in preventing organ damage due to chemotherapeutics was also investigated.…”

Section: Introductionmentioning

confidence: 99%

Protective effects of sildenafil administration on chemotherapeutic-induced ovarian damage in rats

Ergin

Uluutku

Kale

et al. 2022

Can. J. Physiol. Pharmacol.

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Agents to reduce the gonadotoxic effects of chemotherapeutics are still under investigation. In this context, we aimed to investigate the protective effect of sildenafil against chemotherapeutic-induced gonadotoxicity in a rat model. A total of 62 female rats were divided into eight groups as control, sildenafil (1.4 mg/kg, orally), doxorubicin (3 mg/kg, i.p.), cisplatin (5 mg/kg, i.p.), cyclophosphamide (200 mg/kg, i.p.), doxorubicin+sildenafil, cisplatin+sildenafil, and cyclophosphamide+sildenafil (1.4 mg/kg orally sildenafil in addition to the same dose of chemotherapeutics). The groups were compared in terms of follicle count, ovarian size, and anti-müllerian hormone (AMH) levels. Use of sildenafil with cyclophosphamide was effective only in preserving primary follicle count (p = 0.026) and had no significant change in the secondary follicle count, ovarian size, or AMH level. Adding sildenafil to cisplatin had a significant protective effect on primary follicle count (p = 0.011), secondary follicle count (p = 0.009), and ovarian size (p = 0.001), but this effect could not be demonstrated at AMH level. Sildenafil was not effective on any parameter in the doxorubicin group. Sildenafil may be effective in reducing the gonadotoxicity associated with the use of cisplatin and cyclophosphamide.

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Does sildenafil have protective effects against ovarian ischemia-reperfusion injury in rats?

Abstract: The results of the current study showed that the sildenafil treatment can be effective in preventing tissue damage and oxidative stress induced by the ischemia-reperfusion created in rat ovaries.

Cited by 12 publications

References 22 publications

Comparison of the protective effects of sildenafil, vardenafil and tadalafil treatments in ischemia-reperfusion injury in rat ovary

Comparison of the protective effects of sildenafil, vardenafil and tadalafil treatments in ischemia-reperfusion injury in rat ovary

Adnexal torsion in adolescents

Protective effects of sildenafil administration on chemotherapeutic-induced ovarian damage in rats

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