Protective effect of apigenin against N-nitrosodiethylamine (NDEA)-induced hepatotoxicity in albino rats

Ali, Fahad; Rahul, .; Naz, Falaq; Jyoti, Smita; Siddique, Yasir Hasan

doi:10.1016/j.mrgentox.2014.04.006

Cited by 53 publications

(44 citation statements)

References 37 publications

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“…The effects of NDEA on the liver, as noticed in this study, are similar to those previously reported by other authors (Arul & Subramanian 2013;Ali et al 2014). The small preneoplastic focal lesions have been demonstrated to lead into malignant transformation, with the formation of neoplastic nodules and, ultimately, HCC (Shen et al 2014).…”

Section: Discussionsupporting

confidence: 93%

Protective effect of yellow tea extract on N-nitrosodiethylamine-induced liver carcinogenesis

Kujawska

Ewertowska

Adamska

et al. 2016

Pharmaceutical Biology

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Context Yellow tea containing the same catechins as other types of tea but in different proportions has been suggested to possess potent anticancer activities. Objective This study investigates the chemopreventive effect of yellow tea aqueous extract against N-nitrosodiethylamine (NDEA)-induced liver carcinogenesis in rats by employing histological and biochemical methods. Materials and methods Wistar rats were divided randomly into four groups: control (I), yellow tea (II), NDEA (III), and yellow tea + NDEA (IV). Groups II and IV were exposed via a diet to yellow tea extract in a concentration of 10 g/kg feed; groups III and IV received 0.01% NDEA in drinking water. The experiment lasted for 13 weeks. Results Daily intake of yellow tea in an average dose of 800 mg/kg b.w. alleviated the carcinogenic effect of NDEA as evidenced by reversed histopathological changes towards normal hepatocellular architecture and decreased lipid peroxidation, protein carbonyl formation, and DNA degradation by 64%, 37% and 15%, respectively, as compared with values obtained in NDEA alone-treated rats. Treatment with yellow tea extract caused protection of superoxide dismutase (SOD) and catalase (CAT); their activity was recovered by 47% and 12%, respectively, as compared with the NDEAtreated rats. Moreover, the extract normalized the NDEA-induced activity of paraoxonase 1 (PON1) and glutathione peroxidase (GPx), while a further increase in the level of reduced glutathione (GSH) was noticed. Conclusions On the basis of these findings, it can be concluded that treatment with yellow tea partially protected the livers of rats from NDEA-induced hepatocarcinogenesis and that its antioxidant activity contributed to this effect. ARTICLE HISTORY

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Section: Discussionsupporting

confidence: 93%

Protective effect of yellow tea extract on N-nitrosodiethylamine-induced liver carcinogenesis

Kujawska

Ewertowska

Adamska

et al. 2016

Pharmaceutical Biology

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“…These histological findings corroborate those from other studies (19,20). Shen et al reported that in rats exposed to NDEA, small pre-neoplastic focal lesions undergo malignant transformation, with the formation of neoplastic nodules and ultimately HCC (21).…”

Section: Tissue (Black Cross) and Cirrhosis With Deposition Of Connesupporting

confidence: 89%

Protective Effect of Morus alba Leaf Extract on N-Nitrosodiethylamine-induced Hepatocarcinogenesis in Rats

Kujawska

Ewertowska

Adamska

et al. 2016

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Abstract. Background Since primary liver cancer is the third leading cause of cancer mortality worldwide, chemopreventive strategies aimed at reducing its risk or delaying its onset are highly desirable. The most common type of primary liver cancer is an inflammation-associated cancer developing from hepatocytes, hepatocellular carcinoma (HCC). Hepatocarcinogenesis progresses from chronic intrahepatic inflammation within the state of oxidative stress, which results in continuous cellular injury, necrosis and regeneration along with a genotoxic effect (1, 2). Despite a clear viral etiology, HCC is also mediated through exposure to hepatocarcinogens such as nitrosamines, which cause the generation of radicals or cellular mitochondrial dysfunction (2).White mulberry (Morus alba) leaves contain abundant varieties of polyphenols, including chlorogenic acid, rutin, isoquercitrin, quercetin, astragalin and kaempferol, which are considered strong antioxidants (3). Mulberry leaf extract has been reported to scavenge 1,1-diphenyl-2-picryl-hydrazyl radical and prevent lipid peroxidation in rabbit and human low-density lipoproteins (4). Its antioxidant effect has been also revealed in streptozotocin-induced diabetic rats (5). Anticancer properties of mulberry leaf polyphenols have been demonstrated in numerous assays with various types of human cancer cells of colon (6), liver (7), breast (6), and lung (8), and the underlying mechanisms including antioxidant, antiinflammatory, and proliferative, and cytotoxic activity have been shown. However, to the best of our knowledge, the anticancer effect in an animal model has not yet been investigated.The present study was designed to evaluate the chemopreventive effect of mulberry leaf extract on Nnitrosodiethylamine (NDEA)-induced liver carcinogenesis in rats. This experimental model of hepatocarcinogenesis, due to histological and biochemical similarities between rodents and human hepatic lesions, is widely used in chemoprevention studies (9). Materials and MethodsMaterials. Dried and crushed M. alba L. (var. wielkolistna zolwinska) leaves were mixed with water (80-90˚C) using a counterflow process (1:10 w/w) and subjected to continuous extraction in a twin-screw extractor (IBPRS, Poznan, Poland). The resulting extract was then concentrated using a vacuum periodic spherical evaporator

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“…Additionally, our finding also demonstrated that the TFK signifi- (Ali, Rahul, Naz, Jyoti, & Siddique, 2014;Raskovic et al, 2017). Biochanin A (Breikaa, Algandaby, El-Demerdash, & Abdel-Naim, 2013) and oroxylin A (Zhu et al, 2013) have hepatoprotective effects on CCl 4 -induced liver injury.…”

Section: Effects Of Tpk Ttk and Tfk On Tnf-α Inf-γ And Il-4 Levsupporting

confidence: 69%

“…TFK significantly induced the hepatic SOD at 600 mg/kg dosage (Figure b) and GSH‐Px at 200, 400 and 600 mg/kg dosages (Figure c). It is documented that the flavonoid compounds, including apigenin, exert anti‐oxidative and hepatoprotective effects on paracetamol‐ and N ‐nitrosodiethylamine (NDEA)‐induced liver injury (Ali, Rahul, Naz, Jyoti, & Siddique, ; Raskovic et al, ). Biochanin A (Breikaa, Algandaby, El‐Demerdash, & Abdel‐Naim, ) and oroxylin A (Zhu et al, ) have hepatoprotective effects on CCl 4 ‐induced liver injury.…”

Section: Discussionmentioning

confidence: 99%

The hepatoprotective activities of Kalimeris indica ethanol extract against liver injury in vivo

Wang

Zhang

Wang

et al. 2019

Food Science & Nutrition

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Kalimeris indica (L.) Sch. Bip. is a traditional Chinese medicine (TCM) and a portion of food used for cooking in China. It has been demonstrated that an ethanol extract of K. indica has an anti‐inflammatory effect by inhibition of nitric oxide (NO) production on murine macrophage RAW264.7 cells after lipopolysaccharide (LPS) induction. In this study, the hepatoprotective effects of the total phenolics of K. indica (TPK), the total triterpenes of K. indica (TTK), and the total flavones of K. indica (TFK) from ethanol extracts of K. indica were evaluated in Bacille Calmette–Guerin (BCG)/LPS‐induced liver injury in vivo. The treatments of TPK, TTK, and TFK improved liver injury in mice. Additionally, all treatments significantly not only reduced the hepatic malondialdehyde (MDA) content and hepatic total nitric oxide synthase (tNOS) but also induced the hepatic superoxide dismutase (SOD) and glutathione peroxidase (GSH‐Px) activity. The treatments of TPK and TTK significantly reduced the hepatic inducible nitric oxide synthase (iNOS). The treatments of TPK, TTK, and TFK reduced the serum total bilirubin (T‐Bil), and only TFK treatment reduced the serum alanine aminotransferase (ALT). Our results suggest that TPK, TTK, and TFK from ethanol extracts of K. indica might play an essential protective role against BCG/LPS‐induced liver injury in vivo.

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Protective effect of apigenin against N-nitrosodiethylamine (NDEA)-induced hepatotoxicity in albino rats

Cited by 53 publications

References 37 publications

Protective effect of yellow tea extract on N-nitrosodiethylamine-induced liver carcinogenesis

Protective effect of yellow tea extract on N-nitrosodiethylamine-induced liver carcinogenesis

Protective Effect of Morus alba Leaf Extract on N-Nitrosodiethylamine-induced Hepatocarcinogenesis in Rats

The hepatoprotective activities of Kalimeris indica ethanol extract against liver injury in vivo

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