The hepatoprotective activities of <i>Kalimeris indica</i> ethanol extract against liver injury in vivo

Wang, Guo‐Kai; Zhang, Nan; Wang, Yi; Liu, Jinsong; Wang, Gang; Zhou, Zhong‐Yu; Lu, Chi‐Cheng; Yang, Jai Sing

doi:10.1002/fsn3.1241

Cited by 9 publications

(4 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Plant extracts contain phytochemicals which are active in preventing various diseases and may be beneficial to health with moderate consumption. Many studies have explored the potential of plant extracts against liver injuries (Park et al., 2020 ; Wang et al., 2019 ; Zhu et al., 2019 ). The pathology of I/R‐induced hepatic injury reveals that oxidative stress plays a crucial role in the scenario.…”

Section: Discussionmentioning

confidence: 99%

Bracteanolide A abrogates oxidative stress‐induced cellular damage and protects against hepatic ischemia and reperfusion injury in rats

Chao

Hsieh

Kuo

et al. 2021

Food Science & Nutrition

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Bracteanolide A abrogates oxidative stress‐induced cellular damage and protects against hepatic ischemia and reperfusion injury in rats

Chao

Hsieh

Kuo

et al. 2021

Food Science & Nutrition

View full text Add to dashboard Cite

show abstract

“…The pre exposure of liver to the chemicals results in liver injury. CCl4, a potent hepatotoxic agent, is mostly used to study hepatoprotective activity of medicinal plants (Wang et al, 2019).The protective effect of fig fruit on liver enzymes and protein were shown in Figure 1. Induction of CCl4 significantly increased (P < 0.05) the level of liver markers such as alanine transaminase, aspartate aminotransferase, alkaline phosphatase and bilirubin as compared to the normal group.…”

Section: Hepatoprotective Studymentioning

confidence: 99%

Determination of Bioactive Chemicals and Antioxidant Capacity in Different Plant Parts of Coriander (Coriandrum Sativum L.)

2021

THE JAPS

View full text Add to dashboard Cite

Ficus carica (Fig) is considered to be first plant which is cultivated on earth. Fruit of this plant is delicious, medicinally important and is being consumed by human population since centuries. The present study was designed to assess the role of Ficus carica fruit as hepatoprotective agent in animal model. Crude methanolic extract of Ficus carica fruit and its derived n-hexane and aqueous fractions were used to study its curative effect on CCl4 induced toxicity in mice. Animals were divided into seven groups (n=5). Group I animals were treated with normal saline only, Group II was treated with olive oil (vehicle control), Group III was treated with CCl4 (toxic control) 0.2 ml/kg b.w, Group IV was treated with silymarin (standard drug) and Group V, VI and VII were treated with plant extract and fractions at different doses (200 mg/kg and 400 mg/kg b.w). Hepatoprotective effect was determined by investigating liver markers (Alanine transaminase, Aspartate aminotransferase, Alkaline phosphatase and bilirubin) using blood while in vivo antioxidant potential was found out by determining the activity of Glutathione peroxidase, Catalase and Superoxide dismutase. Histopathology of liver was also done. The aqueous fraction showed significant hepatoprotective effect against toxicity in mice as well as exhibited higher antioxidant value. The aqueous fraction of Ficus carica would be a good candidate for pharmaceutical industry as a hepatoprotective agent.

show abstract

“…Previously published research report by Wang et al. ( 2019 ) has reported on about Kalimeris indica ethanolic extract in vivo hepatoprotective effects. The authors have concluded that the extract led to improvement in liver injury in mice and decreasing tendencies in hepatic malondialdehyde (MDA) content and total nitric oxide synthase (tNOS) levels.…”

Section: Introductionmentioning

confidence: 99%

In vivo anti‐Salmonella properties of aqueous extract of prickly pear (Opuntia ficus indica) cladode, hepatological and toxicological evaluation

Iftikhar,

Siddique,

Ameer

et al. 2024

Food Science & Nutrition

View full text Add to dashboard Cite

The present study aimed to evaluate antidiarrheal potential of prickly pear cladode and its hepatoprotective role in different groups of diarrhea‐induced mice. Mice received cefixime (4 mg/kg of bw) and different concentrations of aqueous cladode extract (250 mg/kg of bw, 500 mg/kg of bw and 1000 mg/kg of bw). Feces Salmonella typhi ATCC 19430 was used to assess antidiarrheal potential and hematological, biochemical parameters, and histopathological analyses were carried out for 17 days. The results showed that administration of Salmonella typhi ATCC 19430 in mice produced liver injuries with histological damage, whereas 1000 mg/kg of bw cladode extract reduced the Salmonella typhi ATCC 19430 load of feces earlier as compared to the other groups during 17 days. Hematological parameters, like red blood cells (RBCs) (6.19 ± 1.85 × 106/mm3) and hemoglobin (Hb) (10.06 ± 2.03 g/dL), of negative control group decreased, while white blood cells (WBCs) (13.46 × 106/mm3) increased from reference values. In lipid profile, low‐density lipoprotein (LDL) (9.0 ± 2.41 mg/dL), high‐density lipoprotein (HDL) (6.07 ± 2.45 mg/dL) and total cholesterol (TC) (35.22 ± 8.29 mg/dL) of negative control group decreased, while triglycerides (TG) (168.35 ± 71.75 mg/dL) increased from reference values. Alanine transferase (ALT) (60.30 ± 20.33 IU/L), alkaline phosphatase (ALP) (359.9 ± 100.05 IU/L) and aspartate transferase (AST) (168.77 ± 66.61 IU/L) of negative control group increased from reference values. Urea (27.36 ± 10.54 mmol/L) and creatinine (35.29 ± 12.15 mmol/L) of the negative control group increased. Cefixime also ameliorated injuries due to the administration of Salmonella typhi ATCC 19430. Conclusively, these findings indicated that pure aqueous extract of cladode showed more promising results regarding antidiarrheal potential. Hence, cladode might be used in food and supplement formulations as a functional ingredient.

show abstract

The hepatoprotective activities of Kalimeris indica ethanol extract against liver injury in vivo

Cited by 9 publications

References 45 publications

Bracteanolide A abrogates oxidative stress‐induced cellular damage and protects against hepatic ischemia and reperfusion injury in rats

Bracteanolide A abrogates oxidative stress‐induced cellular damage and protects against hepatic ischemia and reperfusion injury in rats

Determination of Bioactive Chemicals and Antioxidant Capacity in Different Plant Parts of Coriander (Coriandrum Sativum L.)

In vivo anti‐Salmonella properties of aqueous extract of prickly pear (Opuntia ficus indica) cladode, hepatological and toxicological evaluation

Contact Info

Product

Resources

About